Histone deacetylase 3 (HDAC 3) as emerging drug target in NF-κB-mediated inflammation (Q28076052)

Crossref

Martijn RH Zwinderman

series ordinal

2

1 reference

Crossref

language of work or name

1 reference

August 2016

1 reference

Current Opinion in Chemical Biology

published in

1 reference

volume

33

1 reference

page(s)

160-8

1 reference

Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group

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HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity.

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Rugulactone derivatives act as inhibitors of NF-κB activation and modulates the transcription of NF-κB dependent genes in MDA-MB-231cells.

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Targeting histone-modifications in Alzheimer's disease. What is the evidence that this is a promising therapeutic avenue?

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Mutagenesis studies of the 14 Å internal cavity of histone deacetylase 1: insights toward the acetate-escape hypothesis and selective inhibitor design.

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Histone deacetylases and their inhibitors: new implications for asthma and chronic respiratory conditions

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Small molecule inhibitors of histone acetyltransferases and deacetylases are potential drugs for inflammatory diseases.

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Identification of highly selective and potent histone deacetylase 3 inhibitors using click chemistry-based combinatorial fragment assembly.

29 September 2017

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Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit

29 September 2017

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Enhancement of inflammatory protein expression and nuclear factor Κb (NF-Κb) activity by trichostatin A (TSA) in OP9 preadipocytes

29 September 2017

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Toxicological and metabolic considerations for histone deacetylase inhibitors

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The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB.

29 September 2017

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Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages

29 September 2017

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Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation.

29 September 2017

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29 September 2017

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Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay

29 September 2017

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Function of histone deacetylase inhibitors in inflammation.

29 September 2017

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Romidepsin: a novel histone deacetylase inhibitor for cancer

29 September 2017

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Histone Deacetylase Inhibitors for Treating a Spectrum of Diseases Not Related to Cancer

29 September 2017

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HDAC inhibitor MS-275 attenuates the inflammatory reaction in rat experimental autoimmune prostatitis.

29 September 2017

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Histone acetyltransferases are crucial regulators in NF-κB mediated inflammation.

29 September 2017

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Histone deacetylase inhibitor LAQ824 augments inflammatory responses in macrophages through transcriptional regulation of IL-10.

29 September 2017

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Pharmacokinetics, Safety and Inducible Cytokine Responses during a Phase 1 Trial of the Oral Histone Deacetylase Inhibitor ITF2357 (Givinostat)

29 September 2017

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HDAC inhibition in rheumatoid arthritis and juvenile idiopathic arthritis

29 September 2017

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Conditional deletion of histone deacetylase 1 in T cells leads to enhanced airway inflammation and increased Th2 cytokine production

29 September 2017

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The nuclear factor NF-kappaB pathway in inflammation

29 September 2017

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Regulatory signal transduction pathways for class IIa histone deacetylases

29 September 2017

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Posttranslational modifications of NF-kappaB: another layer of regulation for NF-kappaB signaling pathway

29 September 2017

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Chemical phylogenetics of histone deacetylases

29 September 2017

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Histone deacetylase-3 activation promotes tumor necrosis factor-alpha (TNF-alpha) expression in cardiomyocytes during lipopolysaccharide stimulation

29 September 2017

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Histone deacetylase inhibitors activate NF-kappaB in human leukemia cells through an ATM/NEMO-related pathway

29 September 2017

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Transcriptional control of the inflammatory response

29 September 2017

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Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model

29 September 2017

1 reference

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Role of HDAC2 in the pathophysiology of COPD.

29 September 2017

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29 September 2017

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Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65

29 September 2017

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Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

29 September 2017

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Sirtuins: the 'magnificent seven', function, metabolism and longevity

29 September 2017

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Impact of post-translational modifications of proteins on the inflammatory process

29 September 2017

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Anti-rheumatic activities of histone deacetylase (HDAC) inhibitors in vivo in collagen-induced arthritis in rodents.

29 September 2017

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29 September 2017

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Histone deacetylase inhibitors suppress the inducibility of nuclear factor-kappaB by tumor necrosis factor-alpha receptor-1 down-regulation

29 September 2017

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The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo

29 September 2017

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Blockade of histone deacetylase inhibitor-induced RelA/p65 acetylation and NF-kappaB activation potentiates apoptosis in leukemia cells through a process mediated by oxidative damage, XIAP downregulation, and c-Jun N-terminal kinase 1 activation

29 September 2017

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The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines

29 September 2017

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FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity

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Trichostatin A Protects Against Experimental Acute-on-Chronic Liver Failure in Rats Through Regulating the Acetylation of Nuclear Factor-κB.

29 September 2017

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Histone deacetylase inhibitors suppress inflammatory activation of rheumatoid arthritis patient synovial macrophages and tissue

2 June 2018

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Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases

2 June 2018

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Design, synthesis, and biological evaluation of 1, 3-disubstituted-pyrazole derivatives as new class I and IIb histone deacetylase inhibitors

2 June 2018

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Inflammation, Cancer and Oxidative Lipoxygenase Activity are Intimately Linked

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Histone deacetylases are dysregulated in rheumatoid arthritis and a novel histone deacetylase 3-selective inhibitor reduces interleukin-6 production by peripheral blood mononuclear cells from rheumatoid arthritis patients

27 November 2018

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Histone deacetylase inhibitors MS-275 and SAHA induced growth arrest and suppressed lipopolysaccharide-stimulated NF-kappaB p65 nuclear accumulation in human rheumatoid arthritis synovial fibroblastic E11 cells

27 November 2018

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27 November 2018

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Histone deacetylase (HDAC) inhibitors reduce the glial inflammatory response in vitro and in vivo

27 November 2018

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27 November 2018

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Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model

27 November 2018

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Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2).

27 November 2018

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Histone Deacetylase Inhibitor Reduces Monocyte Adhesion to Endothelium Through the Suppression of Vascular Cell Adhesion Molecule-1 Expression

27 November 2018

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A therapeutic strategy uses histone deacetylase inhibitors to modulate the expression of genes involved in the pathogenesis of rheumatoid arthritis

27 November 2018

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Expression and activity of histone deacetylases in human asthmatic airways

27 November 2018

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Synthesis, biological characterization and molecular modeling insights of spirochromanes as potent HDAC inhibitors

27 November 2018

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inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Depletion of histone deacetylase protein: a common consequence of inflammatory cytokine signaling?

1 reference

https://pubmed.ncbi.nlm.nih.gov/27371876

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Smoke exposure of human macrophages reduces HDAC3 activity, resulting in enhanced inflammatory cytokine production

1 reference

https://pubmed.ncbi.nlm.nih.gov/27371876

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CBPA.2016.06.019

0 references

1 reference

PubMed publication ID

27371876

1 reference