Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model (Q27851780)

PubMed

PubMed publication ID

22550175

13 November 2016

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22550175%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

title

Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model (English)

2 references

PubMed

PubMed publication ID

22550175

13 November 2016

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22550175%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

0 references

1 reference

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22550175%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

author name string

Michelle J Lee

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22550175%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Beryl A Hatton

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22550175%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Elisabeth H Villavicencio

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22550175%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Paritosh C Khanna

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22550175%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Sally Ditzler

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22550175%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Barbara Pullar

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22550175%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Keith Robison

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22550175%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Kerry F White

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22550175%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Chris Tunkey

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22550175%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Michael LeBlanc

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22550175%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Julie Randolph-Habecker

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22550175%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Sue E Knoblaugh

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22550175%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Stacey Hansen

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22550175%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Andrew Richards

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22550175%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Brandon J Wainwright

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22550175%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Karen McGovern

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22550175%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

James M Olson

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22550175%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

language of work or name

English

0 references

publication date

1 May 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22550175%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

30 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22550175%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

volume

109

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22550175%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

issue

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22550175%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

page(s)

7859-7864

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22550175%20AND%20SRC:MED&resulttype=core&format=json

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

30 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

Tumor paint: a chlorotoxin:Cy5.5 bioconjugate for intraoperative visualization of cancer foci

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

Patched1 functions as a gatekeeper by promoting cell cycle progression

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

Identification of OTX2 as a medulloblastoma oncogene whose product can be targeted by all-trans retinoic acid

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

An animal model of MYC-driven medulloblastoma

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

Hedgehog Fights Back: Mechanisms of Acquired Resistance against Smoothened Antagonists

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

Regulation of cell cycle genes and induction of senescence by overexpression of OTX2 in medulloblastoma cell lines

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

Medulloblastoma comprises four distinct molecular variants

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

Medulloblastoma: from molecular pathology to therapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

Drug resistance in brain diseases and the role of drug efflux transporters.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

2 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1114718109

21 January 2018

Identifiers

DOI

10.1073/PNAS.1114718109

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22550175%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

ADS bibcode

2012PNAS..109.7859L

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22550175%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

PubMed publication ID

22550175

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22550175%20AND%20SRC:MED&resulttype=core&format=json