Targeting Mycobacterium tuberculosis nucleoid-associated protein HU with structure-based inhibitors (Q27690716)

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7 June 2020

author name string

Tuhin Bhowmick

1

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7 June 2020

Karuna Dixit

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7 June 2020

Varsha Ganesan

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7 June 2020

Udupi A Ramagopal

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7 June 2020

Debayan Dey

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7 June 2020

Siddhartha P Sarma

7

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7 June 2020

Suryanarayanarao Ramakumar

8

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7 June 2020

Valakunja Nagaraja

9

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7 June 2020

language of work or name

English

0 references

publication date

11 June 2014

0 references

published in

Nature Communications

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7 June 2020

volume

5

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7 June 2020

page(s)

4124

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The histone-like protein HU binds specifically to DNA recombination and repair intermediates

7 June 2020

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Architectural organization in E. coli nucleoid

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E. coli DNA binding protein HU forms nucleosome-like structure with circular double-stranded DNA

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Flexible DNA bending in HU-DNA cocrystal structures

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The HU regulon is composed of genes responding to anaerobiosis, acid stress, high osmolarity and SOS induction

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Multiple defects in Escherichia coli mutants lacking HU protein

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Genes required for mycobacterial growth defined by high density mutagenesis

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Optimal description of a protein structure in terms of multiple groups undergoing TLS motion

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Right-handed DNA supercoiling by an octameric form of histone-like protein HU: modulation of cellular transcription.

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Nucleoid remodeling by an altered HU protein: reorganization of the transcription program

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Resazurin microtiter assay plate: simple and inexpensive method for detection of drug resistance in Mycobacterium tuberculosis.

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An alternate conformation of the hyperthermostable HU protein from Thermotoga maritima has unexpectedly high flexibility.

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Relationship between nuclear magnetic resonance chemical shift and protein secondary structure

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Bacterial nucleoid-associated proteins, nucleoid structure and gene expression

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Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

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Refinement of macromolecular structures by the maximum-likelihood method

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Use of TLS parameters to model anisotropic displacements in macromolecular refinement

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An improved PCR-mutagenesis strategy for two-site mutagenesis or sequence swapping between related genes

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Permeabilization of the mycobacterial envelope for protein cytolocalization studies by immunofluorescence microscopy

21 January 2018

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Development of a repressible mycobacterial promoter system based on two transcriptional repressors

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A Conformational Ensemble Derived Using NMR Methyl Chemical Shifts Reveals a Mechanical Clamping Transition That Gates the Binding of the HU Protein to DNA

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inferred from DOI database lookup

7 January 2021

based on heuristic

Making DNA do a U-turn: IHF and related proteins

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inferred from DOI database lookup

7 January 2021

based on heuristic

Arginine-55 in the beta-arm is essential for the activity of DNA-binding protein HU from Bacillus stearothermophilus

1 reference

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NCOMMS5124

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24916461%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

7 June 2020

ADS bibcode

2014NatCo...5.4124B

0 references

1044161289

0 references

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24916461%20AND%20SRC:MED&resulttype=core&format=json