Structure of sugar-bound LacY (Q27681433)

1

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Vladimir Kasho

2

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Irina Smirnova

3

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Janet S Finer-Moore

4

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Robert M Stroud

Proceedings of the National Academy of Sciences of the United States of America

6

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language of work or name

English

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publication date

4 February 2014

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published in

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volume

111

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issue

5

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page(s)

1784-8

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cites work

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The Alternating Access Transport Mechanism in LacY

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Delineating electrogenic reactions during lactose/H+ symport

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Sugar binding induces the same global conformational change in purified LacY as in the native bacterial membrane

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Sugar binding induces an outward facing conformation of LacY.

29 September 2017

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29 September 2017

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29 September 2017

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Lessons from lactose permease

29 September 2017

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Sequence alignment and homology threading reveals prokaryotic and eukaryotic proteins similar to lactose permease

29 September 2017

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29 September 2017

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Exploiting luminescence spectroscopy to elucidate the interaction between sugar and a tryptophan residue in the lactose permease of Escherichia coli

29 September 2017

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Elucidation of substrate binding interactions in a membrane transport protein by mass spectrometry

29 September 2017

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Aromatic stacking in the sugar binding site of the lactose permease

29 September 2017

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Changing the lactose permease of Escherichia coli into a galactose-specific symporter

29 September 2017

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Unraveling the mechanism of the lactose permease of Escherichia coli

29 September 2017

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Characterization of Glu126 and Arg144, two residues that are indispensable for substrate binding in the lactose permease of Escherichia coli

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918835

Cys-scanning mutagenesis: a novel approach to structure function relationships in polytopic membrane proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918835

The substrate-binding site in the lactose permease of Escherichia coli

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918835

Fourier transform infrared spectroscopy reveals a rigid alpha-helical assembly for the tetrameric Streptomyces lividans K+ channel

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918835

Interaction between Residues Glu269 (Helix VIII) and His322 (Helix X) of the Lactose Permease of Escherichia coli Is Essential for Substrate Binding

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918835

Role of glutamate-269 in the lactose permease of Escherichia coli

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918835

Site-specific mutagenesis of histidine residues in the lac permease of Escherichia coli

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918835

Functional interactions between putative intramembrane charged residues in the lactose permease of Escherichia coli

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918835

Site-directed alkylation studies with LacY provide evidence for the alternating access model of transport

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918835

Thiol cross-linking of transmembrane domains IV and V in the lactose permease of Escherichia coli

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918835

Ligand recognition by the lactose permease of Escherichia coli: specificity and affinity are defined by distinct structural elements of galactopyranosides

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918835

Cysteine-Scanning Mutagenesis of Helix IV and the Adjoining Loops in the Lactose Permease of Escherichia coli: Glu126 and Arg144 Are Essential

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918835

Properties of interacting aspartic acid and lysine residues in the lactose permease of Escherichia coli.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918835

The alternating-access mechanism of MFS transporters arises from inverted-topology repeats.

2 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1324141111

Structural characterization of the osmosensor ProP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1324141111

The C-4 hydroxyl group of galactopyranosides is the major determinant for ligand recognition by the lactose permease of Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1324141111

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

12 December 2020

lac permease of Escherichia coli: histidine-205 and histidine-322 play different roles in lactose/H+ symport

1 reference

12 December 2020

Mechanism of lactose translocation in proteoliposomes reconstituted with lac carrier protein purified from Escherichia coli. II. Deuterium solvent isotope effects

1 reference

12 December 2020

Fourier transform infrared analysis of purified lactose permease: a monodisperse lactose permease preparation is stably folded, alpha-helical, and highly accessible to deuterium exchange

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1324141111

1 reference

ADS bibcode

2014PNAS..111.1784K

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1 reference

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PubMed publication ID

24453216

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