Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14α-Demethylase (CYP51) from Leishmania infantum (Q27668116)

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English	Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14α-Demethylase (CYP51) from Leishmania infantum	scientific article

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scholarly article

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Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14α-Demethylase (CYP51) from Leishmania infantum (English)

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Lanosterol 14-alpha demethylase

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5 February 2019

sterol 14-alpha-demethylase

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Leishmania infantum

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based on heuristic

inferred from title

Zdzislaw Wawrzak

2

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author name string

Tatiana Y Hargrove

1

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Jialin Liu

3

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W David Nes

4

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Michael R Waterman

5

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Galina I Lepesheva

6

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language of work or name

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publication date

29 July 2011

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Journal of Biological Chemistry

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286

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30

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26838-48

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Structural and Biochemical Characterization of Mycobacterium tuberculosis CYP142: EVIDENCE FOR MULTIPLE CHOLESTEROL 27-HYDROXYLASE ACTIVITIES IN A HUMAN PATHOGEN

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20 March 2017

Structural Insights into Inhibition of Sterol 14 -Demethylase in the Human Pathogen Trypanosoma cruzi

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20 March 2017

Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections

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20 March 2017

Comparative genomic analysis of three Leishmania species that cause diverse human disease

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20 March 2017

Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone

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20 March 2017

An open conformation of mammalian cytochrome P450 2B4 at 1.6-Å resolution

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20 March 2017

Ultrastructural and biochemical alterations induced by 22,26-azasterol, a delta(24(25))-sterol methyltransferase inhibitor, on promastigote and amastigote forms of Leishmania amazonensis.

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20 March 2017

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20 March 2017

Refinement of macromolecular structures by the maximum-likelihood method

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20 March 2017

Fluconazole for the treatment of cutaneous leishmaniasis caused by Leishmania major

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20 March 2017

Cloning and expression in Escherichia coli of the obtusifoliol 14 alpha-demethylase of Sorghum bicolor (L.) Moench, a cytochrome P450 orthologous to the sterol 14 alpha-demethylases (CYP51) from fungi and mammals

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20 March 2017

THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE

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7 April 2017

Advances in leishmaniasis

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7 April 2017

Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143644

29 September 2017

Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51).

1 reference

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29 September 2017

Leishmaniasis Vaccine: Where are We Today?

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29 September 2017

Structural basis for conservation in the CYP51 family

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29 September 2017

Kinetic analysis of the three-step steroid aromatase reaction of human cytochrome P450 19A1.

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29 September 2017

Update on azole antifungals

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29 September 2017

Recent advances in antifungal chemotherapy

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29 September 2017

Transmission of Leishmania metacyclic promastigotes by phlebotomine sand flies.

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29 September 2017

Leishmania and the leishmaniases: a parasite genetic update and advances in taxonomy, epidemiology and pathogenicity in humans

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29 September 2017

Biodiversity of CYP51 in trypanosomes

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29 September 2017

Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms

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29 September 2017

Structural basis for ligand promiscuity in cytochrome P450 3A4.

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29 September 2017

Challenges and new discoveries in the treatment of leishmaniasis.

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29 September 2017

CYP51--the omnipotent P450.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143644

29 September 2017

Cytochrome P450 flexibility

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29 September 2017

Neutral thiol as a proximal ligand to ferrous heme iron: implications for heme proteins that lose cysteine thiolate ligation on reduction

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29 September 2017

A novel sterol 14alpha-demethylase/ferredoxin fusion protein (MCCYP51FX) from Methylococcus capsulatus represents a new class of the cytochrome P450 superfamily

1 reference

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29 September 2017

Sterol 14-demethylase P450 (CYP51) provides a breakthrough for the discussion on the evolution of cytochrome P450 gene superfamily

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29 September 2017

Optimized expression and catalytic properties of a wheat obtusifoliol 14alpha-demethylase (CYP51) expressed in yeast. Complementation of erg11Delta yeast mutants by plant CYP51.

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29 September 2017

The Pharmacology of Leishmaniasis

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29 September 2017

Expression and enzymatic activity of recombinant cytochrome P450 17 alpha-hydroxylase in Escherichia coli

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29 September 2017

Properties and structural requirements for substrate specificity of cytochrome P-450-dependent obtusifoliol 14 α-demethylase from maize (Zea mays) seedlings

1 reference

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2 June 2018

CYP51 from Trypanosoma cruzi: a phyla-specific residue in the B' helix defines substrate preferences of sterol 14alpha-demethylase

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21 January 2018

CYP51 from Trypanosoma brucei is obtusifoliol-specific

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21 January 2018

Conservation in the CYP51 family. Role of the B' helix/BC loop and helices F and G in enzymatic function

1 reference

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21 January 2018

Folding requirements are different between sterol 14alpha-demethylase (CYP51) from Mycobacterium tuberculosis and human or fungal orthologs

1 reference

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21 January 2018

EpoK, a cytochrome P450 involved in biosynthesis of the anticancer agents epothilones A and B. Substrate-mediated rescue of a P450 enzyme

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21 January 2018

Membrane binding and substrate access merge in cytochrome P450 7A1, a key enzyme in degradation of cholesterol

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21 January 2018

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21 January 2018

Cytochrome P-450-dependent oxidation of lanosterol in cholesterol biosynthesis. Microsomal electron transport and C-32 demethylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21632531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Yeast cytochrome P-450 catalyzing lanosterol 14 alpha-demethylation. I. Purification and spectral properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/21632531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanistic studies of lanosterol C-32 demethylation. Conditions which promote oxysterol intermediate accumulation during the demethylation process

1 reference

https://pubmed.ncbi.nlm.nih.gov/21632531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Post-HMG CoA reductase regulation of cholesterol biosynthesis in normal human lymphocytes: Lanosten-3β-ol-32-al, a natural inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/21632531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of antimycotic azoles on growth and sterol biosynthesis of Leishmania promastigotes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21632531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/21632531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative demethylation of lanosterol in cholesterol biosynthesis: accumulation of sterol intermediates

1 reference

https://pubmed.ncbi.nlm.nih.gov/21632531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of caveolae in Leishmania chagasi phagocytosis and intracellular survival in macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/21632531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conformational dynamics and molecular interaction reactions of recombinant cytochrome p450scc (CYP11A1) detected by fluorescence energy transfer

1 reference

https://pubmed.ncbi.nlm.nih.gov/21632531

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based on heuristic

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Identifiers

10.1074/JBC.M111.237099

1 reference

Consolidated OpenCitations Corpus – April 2017

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OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

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