Structural basis for the function and inhibition of an influenza virus proton channel (Q27649742)

7

0 references

David Salom

David Salom

3

0 references

Luigi Di Costanzo

Luigi Di Costanzo

5

0 references

Vikas Nanda

Vikas Nanda

8

0 references

William DeGrado

10

William F DeGrado

0 references

Steven Stayrook

9

Steven Stayrook

0 references

Amanda L Stouffer

1

Amanda L Stouffer

0 references

Rudresh Acharya

2

Rudresh Acharya

0 references

author name string

Anna S Levine

4

0 references

Cinque S Soto

Structural investigation of rimantadine inhibition of the AM2-BM2 chimera channel of influenza viruses

6

0 references

language of work or name

English

0 references

publication date

31 January 2008

0 references

published in

Nature

0 references

volume

451

0 references

issue

7178

0 references

page(s)

596-9

0 references

cites work

1 reference

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Insight into the Mechanism of the Influenza A Proton Channel from a Structure in a Lipid Bilayer

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Influenza virus M2 protein mediates ESCRT-independent membrane scission

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Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus

20 March 2017

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Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers

20 March 2017

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Structure of Amantadine-Bound M2 Transmembrane Peptide of Influenza A in Lipid Bilayers from Magic-Angle-Spinning Solid-State NMR: The Role of Ser31 in Amantadine Binding

20 March 2017

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Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel

20 March 2017

1 reference

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Structure and mechanism of the M2 proton channel of influenza A virus

20 March 2017

1 reference

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Backbone Structure of the Amantadine-Blocked Trans-Membrane Domain M2 Proton Channel from Influenza A Virus

20 March 2017

1 reference

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Structure of the transmembrane region of the M2 protein H+ channel

20 March 2017

1 reference

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Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block

20 March 2017

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20 March 2017

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7 January 2021

The gate of the influenza virus M2 proton channel is formed by a single tryptophan residue

1 reference

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Mechanism for proton conduction of the M(2) ion channel of influenza A virus

20 March 2017

1 reference

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Incidence of adamantane resistance among influenza A (H3N2) viruses isolated worldwide from 1994 to 2005: a cause for concern

20 March 2017

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Chemical rescue of histidine selectivity filter mutants of the M2 ion channel of influenza A virus

20 March 2017

1 reference

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Direct Measurement of Distances and Angles in Biomolecules by NMR in a Dilute Liquid Crystalline Medium

20 March 2017

1 reference

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pH-dependent tetramerization and amantadine binding of the transmembrane helix of M2 from the influenza A virus

20 March 2017

1 reference

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Hydrogen-bonding partner of the proton-conducting histidine in the influenza M2 proton channel revealed from 1H chemical shifts

20 March 2017

1 reference

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Paramagnetic Cu(II) for probing membrane protein structure and function: inhibition mechanism of the influenza M2 proton channel.

29 September 2017

1 reference

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NMR determination of protein partitioning into membrane domains with different curvatures and application to the influenza M2 peptide

29 September 2017

1 reference

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Membrane protein structure and dynamics from NMR spectroscopy

29 September 2017

1 reference

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NMR detection of pH-dependent histidine-water proton exchange reveals the conduction mechanism of a transmembrane proton channel.

29 September 2017

1 reference

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Computational studies of influenza A virus at three important targets: hemagglutinin, neuraminidase and M2 protein

29 September 2017

1 reference

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Evolutionary genomics of the pandemic 2009 H1N1 influenza viruses (pH1N 1v).

29 September 2017

1 reference

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Adamantane- and oseltamivir-resistant seasonal A (H1N1) and pandemic A (H1N1) 2009 influenza viruses in Guangdong, China, during 2008 and 2009

29 September 2017

1 reference

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Evaluation of the antiviral drug susceptibility of influenza viruses in Italy from 2004/05 to 2009/10 epidemics and from the recent 2009 pandemic

29 September 2017

1 reference

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Tidal surge in the M2 proton channel, sensed by 2D IR spectroscopy

29 September 2017

1 reference

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[The 2009 pandemic influenza in Russia. I. Diagnosis and molecular biological characteristics of the virus].

29 September 2017

1 reference

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Monitoring and characterization of oseltamivir-resistant pandemic (H1N1) 2009 virus, Japan, 2009-2010.

29 September 2017

1 reference

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Multiple Proton Confinement in the M2 Channel from the Influenza A Virus

29 September 2017

1 reference

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Structural and dynamic mechanisms for the function and inhibition of the M2 proton channel from influenza A virus.

29 September 2017

1 reference

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Solid-State NMR Studies of Amyloid Fibril Structure

29 September 2017

1 reference

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Comprehensive assessment of 2009 Pandemic Influenza a (H1N1) Virus Drug Susceptibility in vitro

29 September 2017

1 reference

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Kinetic analysis of the M2 proton conduction of the influenza virus.

29 September 2017

1 reference

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Mechanisms of proton conduction and gating in influenza M2 proton channels from solid-state NMR

29 September 2017

1 reference

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Conformational plasticity of the influenza A M2 transmembrane helix in lipid bilayers under varying pH, drug binding, and membrane thickness.

29 September 2017

1 reference

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Influence of solubilizing environments on membrane protein structures

29 September 2017

1 reference

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Proton and cation transport activity of the M2 proton channel from influenza A virus

29 September 2017

1 reference

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Coexistence of two adamantane binding sites in the influenza A M2 ion channel

29 September 2017

1 reference

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Computational study of drug binding to the membrane-bound tetrameric M2 peptide bundle from influenza A virus

29 September 2017

1 reference

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Where does amantadine bind to the influenza virus M2 proton channel?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3889492

Genetic makeup of amantadine-resistant and oseltamivir-resistant human influenza A/H1N1 viruses

29 September 2017

1 reference

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Conformational changes of an ion channel detected through water-protein interactions using solid-state NMR spectroscopy

29 September 2017

1 reference

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Binding hot spots and amantadine orientation in the influenza a virus M2 proton channel

29 September 2017

1 reference

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Genomic events underlying the changes in adamantane resistance among influenza A(H3N2) viruses during 2006-2008.

29 September 2017

1 reference

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An amantadine-sensitive chimeric BM2 ion channel of influenza B virus has implications for the mechanism of drug inhibition

29 September 2017

1 reference

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Structure and function of the influenza A M2 proton channel

29 September 2017

1 reference

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Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel

29 September 2017

1 reference

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Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus

29 September 2017

1 reference

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Accurate measurement of methyl 13C chemical shifts by solid-state NMR for the determination of protein side chain conformation: the influenza a M2 transmembrane peptide as an example

29 September 2017

1 reference

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Free-energy profiles for ions in the influenza M2-TMD channel

29 September 2017

1 reference

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Structure and dynamics of membrane proteins by magic angle spinning solid-state NMR.

29 September 2017

1 reference

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High prevalence of amantadine resistance among circulating European porcine influenza A viruses

29 September 2017

1 reference

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Molecular dynamics calculations suggest a conduction mechanism for the M2 proton channel from influenza A virus

29 September 2017

1 reference

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The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza A virus

29 September 2017

1 reference

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Amantadine-induced conformational and dynamical changes of the influenza M2 transmembrane proton channel.

29 September 2017

1 reference

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Solid-state NMR characterization of conformational plasticity within the transmembrane domain of the influenza A M2 proton channel

29 September 2017

1 reference

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Surveillance of resistance to adamantanes among influenza A(H3N2) and A(H1N1) viruses isolated worldwide

29 September 2017

1 reference

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The genesis and spread of reassortment human influenza A/H3N2 viruses conferring adamantane resistance

29 September 2017

1 reference

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Oligomeric structure, dynamics, and orientation of membrane proteins from solid-state NMR.

29 September 2017

1 reference

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Distinct domains of the influenza a virus M2 protein cytoplasmic tail mediate binding to the M1 protein and facilitate infectious virus production

29 September 2017

1 reference

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Amantadine resistance among porcine H1N1, H1N2, and H3N2 influenza A viruses isolated in Germany between 1981 and 2001.

29 September 2017

1 reference

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Histidines, heart of the hydrogen ion channel from influenza A virus: toward an understanding of conductance and proton selectivity.

29 September 2017

1 reference

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Solid-state NMR studies of the structure, dynamics, and assembly of beta-sheet membrane peptides and alpha-helical membrane proteins with antibiotic activities

29 September 2017

1 reference

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The M2 proton channels of influenza A and B viruses

29 September 2017

1 reference

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Generation and characterization of recombinant influenza A (H1N1) viruses harboring amantadine resistance mutations

29 September 2017

1 reference

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Influence of residue 44 on the activity of the M2 proton channel of influenza A virus.

29 September 2017

1 reference

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High-resolution solid-state NMR applied to polypeptides and membrane proteins

29 September 2017

1 reference

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Initial structural and dynamic characterization of the M2 protein transmembrane and amphipathic helices in lipid bilayers

29 September 2017

1 reference

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Emergence of amantadine-resistant influenza A viruses: epidemiological study

29 September 2017

1 reference

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Roles of the histidine and tryptophan side chains in the M2 proton channel from influenza A virus

29 September 2017

1 reference

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Voltage-gated proton channels and other proton transfer pathways

29 September 2017

1 reference

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Sequence determinants of the energetics of folding of a transmembrane four-helix-bundle protein.

29 September 2017

1 reference

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Definitive assignment of proton selectivity and attoampere unitary current to the M2 ion channel protein of influenza A virus

29 September 2017

1 reference

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Permeation and activation of the M2 ion channel of influenza A virus.

29 September 2017

1 reference

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Total chemical synthesis of the integral membrane protein influenza A virus M2: role of its C-terminal domain in tetramer assembly.

29 September 2017

1 reference

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The M2 ectodomain is important for its incorporation into influenza A virions

29 September 2017

1 reference

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A functionally defined model for the M 2 proton channel of influenza A virus suggests a mechanism for its ion selectivity

29 September 2017

1 reference

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Ion selectivity and activation of the M2 ion channel of influenza virus

29 September 2017

1 reference

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Characterization of inhibition of M2 ion channel activity by BL-1743, an inhibitor of influenza A virus

29 September 2017

1 reference

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Influenza virus M2 protein and haemagglutinin conformation changes during intracellular transport

29 September 2017

1 reference

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Activation of the M2 ion channel of influenza virus: a role for the transmembrane domain histidine residue

29 September 2017

1 reference

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The molecular basis of the specific anti-influenza action of amantadine

29 September 2017

1 reference

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Influenza virus M2 protein has ion channel activity

29 September 2017

1 reference

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Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2.

29 September 2017

1 reference

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Membrane-dependent effects of a cytoplasmic helix on the structure and drug binding of the influenza virus M2 protein.

2 June 2018

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Specific binding of adamantane drugs and direction of their polar amines in the pore of the influenza M2 transmembrane domain in lipid bilayers and dodecylphosphocholine micelles determined by NMR spectroscopy

2 June 2018

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Functional studies and modeling of pore-lining residue mutants of the influenza a virus M2 ion channel

2 June 2018

1 reference

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Reversion of influenza A (H3N2) virus from amantadine resistant to amantadine sensitive by further reassortment in Japan during the 2006-to-2007 influenza season

2 June 2018

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Protonation of histidine and histidine-tryptophan interaction in the activation of the M2 ion channel from influenza a virus

2 June 2018

1 reference

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The influenza A virus M2 channel: a molecular modeling and simulation study.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3889492

Influence of amantadine resistance mutations on the pH regulatory function of the M2 protein of influenza A viruses

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3889492

Phylogenetic analysis of an off-seasonal influenza virus A (H3N2) in Niigata, Japan, 2010.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3889492

Emergence and Phylogenetic Analysis of Amantadine-Resistant Influenza A Subtype H3N2 Viruses in Dublin, Ireland, over Six Seasons from 2003/2004 to 2008/2009

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3889492

Emergence of amantadine-resistant avian influenza H5N1 virus in India

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3889492

Proton transport through the influenza A M2 channel: three-dimensional reference interaction site model study

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3889492

Why amantadine loses its function in influenza m2 mutants: MD simulations.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3889492

Side-chain conformation of the M2 transmembrane peptide proton channel of influenza a virus from 19F solid-state NMR.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3889492

Adamantane resistance among influenza A viruses isolated early during the 2005-2006 influenza season in the United States

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3889492

Reorientation phenomena in imidazolium methyl sulfonate as probed by advanced solid-state NMR.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3889492

Variability in the pKa of histidine side-chains correlates with burial within proteins

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3889492

Cu(II) inhibition of the proton translocation machinery of the influenza A virus M2 protein

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3889492

Selective proton permeability and pH regulation of the influenza virus M2 channel expressed in mouse erythroleukaemia cells.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3889492

Differences in conductance of M2 proton channels of two influenza viruses at low and high pH

27 November 2018

1 reference

12 December 2020

High frequency of resistant viruses harboring different mutations in amantadine-treated children with influenza

1 reference

12 December 2020

Structure determination of membrane proteins by NMR spectroscopy

1 reference

12 December 2020

Quantitative analysis of influenza M2 channel blockers

1 reference

12 December 2020

Free energy calculations on the two drug binding sites in the M2 proton channel

1 reference

12 December 2020

Two models of the influenza A M2 channel domain: verification by comparison

1 reference

12 December 2020

Two possible conducting states of the influenza A virus M2 ion channel

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06528

7 January 2021

Multiscale simulation of transmembrane proteins.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06528

7 January 2021

The chemical and dynamical influence of the anti-viral drug amantadine on the M2 proton channel transmembrane domain

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06528

7 January 2021

The transmembrane domain of influenza A M2 protein forms amantadine-sensitive proton channels in planar lipid bilayers

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06528

7 January 2021

Determining the orientation of uniaxially rotating membrane proteins using unoriented samples: a 2H, 13C, AND 15N solid-state NMR investigation of the dynamics and orientation of a transmembrane helical bundle.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06528

7 January 2021

Sequence determinants of a transmembrane proton channel: an inverse relationship between stability and function

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06528

7 January 2021

https://api.crossref.org/works/10.1038%2FNATURE06528

1 reference

7 January 2021

Studies of structural changes in the M2 proton channel of influenza A virus by tryptophan fluorescence

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06528

7 January 2021

Antiviral agents active against influenza A viruses.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06528

7 January 2021

Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06528

7 January 2021

The closed state of a H+ channel helical bundle combining precise orientational and distance restraints from solid state NMR

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06528

7 January 2021

The influenza virus M2 ion channel protein: probing the structure of the transmembrane domain in intact cells by using engineered disulfide cross-linking

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06528

7 January 2021

Crystal structure and mechanism of a calcium-gated potassium channel

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06528

7 January 2021

Influenza A virus M2 ion channel protein: a structure-function analysis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06528

7 January 2021

Asparagine-mediated self-association of a model transmembrane helix

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06528

7 January 2021

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06528

7 January 2021

Solvent content of protein crystals

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06528

7 January 2021

The CCP4 suite: programs for protein crystallography

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06528

7 January 2021

Algorithms for finding the axis of a helix: fast rotational and parametric least-squares methods.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06528

7 January 2021

Identifiers

DOI

10.1038/NATURE06528

1 reference

Dimensions Publication ID

1043530225

0 references

Fatcat ID

release_kpjzqum5bfbedl3tkivhwc42dq

0 references

1 reference

1 reference

PubMed publication ID

18235504

1 reference