Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity (Q27641624)

1

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Huanchen Wang

2

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Yingjie Sun

3

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Hwa-Young Kim

4

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Yudong Liu

Molecular diversity of cyclic AMP signalling

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publication date

July 2003

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published in

Structure

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volume

11

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issue

7

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page(s)

865-73

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cites work

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Identification of inhibitor specificity determinants in a mammalian phosphodiesterase

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Association of the anti-inflammatory activity of phosphodiesterase 4 (PDE4) inhibitors with either inhibition of PDE4 catalytic activity or competition for [3H]rolipram binding

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New phosphodiesterase inhibitors as therapeutics for the treatment of chronic lung disease

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Is phosphodiesterase inhibition a new mechanism of antidepressant action? A double blind double-dummy study between rolipram and desipramine in hospitalized major and/or endogenous depressives

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7 January 2021

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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Cyclic GMP phosphodiesterase-5: target of sildenafil

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Molecular docking of competitive phosphodiesterase inhibitors

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Phosphodiesterase 4 inhibitors and the treatment of asthma: where are we now and where do we go from here?

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Adaptation in cyclic AMP signalling processes: A central role for cyclic AMP phosphodiesterases

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Tailoring cAMP-signalling responses through isoform multiplicity

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7 January 2021

The next generation of PDE4 inhibitors

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Improved methods for building protein models in electron density maps and the location of errors in these models

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Striking Effect of Hydroxamic Acid Substitution on the Phosphodiesterase Type 4 (PDE4) and TNFα Inhibitory Activity of Two Series of Rolipram Analogues: Implications for a New Active Site Model of PDE4

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7 January 2021

Conformational difference between PDE4 apoenzyme and holoenzyme

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Purification and characterization of the human PDE4A catalytic domain (PDE4A330-723) expressed in Sf9 cells

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7 January 2021

Crystal structure of phosphodiesterase 4D and inhibitor complex(1)

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7 January 2021

Dissecting the cofactor-dependent and independent bindings of PDE4 inhibitors.

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Type III cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE3 gene family)

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Cyclic nucleotide phosphodiesterases and their role in endocrine cell signaling.

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Subtypes of the type 4 cAMP phosphodiesterases: structure, regulation and selective inhibition

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[33] AMoRe: An automated molecular replacement program package

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Processing of X-ray diffraction data collected in oscillation mode

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7 January 2021

Phosphodiesterase 4 inhibitors, structurally unrelated to rolipram, as promising agents for the treatment of asthma and other pathologies

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7 January 2021

Cilostazol: treatment of intermittent claudication

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7 January 2021

Identification of inhibitor binding sites of the cAMP-specific phosphodiesterase 4.

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7 January 2021

Human Recombinant Phosphodiesterase 4B2B Binds (R)-Rolipram at a Single Site with Two Affinities

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Phosphodiesterase 5 inhibitors: current status and potential applications

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Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions

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7 January 2021

Immunosuppressive and anti-inflammatory effects of cyclic AMP phosphodiesterase (PDE) type 4 inhibitors

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Phosphodiesterase 4 inhibitors for the treatment of COPD.

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Cyclic nucleotide phosphodiesterases: pharmacology, biochemistry and function

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Phosphodiesterase isozymes: molecular targets for novel antiasthma agents

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7 January 2021

Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity

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