Topography of a 2.0 Å structure of α1-antitrypsin reveals targets for rational drug design to prevent conformational disease (Q27626230)

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X Y Pei

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T R Dafforn

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D A Lomas

Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease

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publication date

July 2000

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published in

Protein Science

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volume

9

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issue

7

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page(s)

1274-81

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cites work

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The crystal structure of plasminogen activator inhibitor 2 at 2.0 A resolution: implications for serpin function

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The native strains in the hydrophobic core and flexible reactive loop of a serine protease inhibitor: crystal structure of an uncleaved alpha1-antitrypsin at 2.7 A

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Inhibitory conformation of the reactive loop of alpha 1-antitrypsin

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The S variant of human alpha 1-antitrypsin, structure and implications for function and metabolism

20 March 2017

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Crystal structure of cleaved human alpha 1-antichymotrypsin at 2.7 A resolution and its comparison with other serpins

20 March 2017

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Familial dementia caused by polymerization of mutant neuroserpin

20 March 2017

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The serpin superfamily of proteinase inhibitors: structure, function, and regulation

20 March 2017

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Torsion angle dynamics: reduced variable conformational sampling enhances crystallographic structure refinement

20 March 2017

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Crystal structure of cleaved equine leucocyte elastase inhibitor determined at 1.95 A resolution

29 September 2017

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Functional effects of single amino acid substitutions in the region of Phe113 to Asp138 in the plasminogen activator inhibitor 1 molecule

29 September 2017

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2 June 2018

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2 June 2018

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Structural basis of latency in plasminogen activator inhibitor-1

2 June 2018

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Identification of the Binding Site for a Low-Molecular-Weight Inhibitor of Plasminogen Activator Inhibitor Type 1 by Site-Directed Mutagenesis

19 June 2018

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Latent alpha1-antichymotrypsin. A molecular explanation for the inactivation of alpha1-antichymotrypsin in chronic bronchitis and emphysema

27 November 2018

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Identification of nine novel mutations in type I antithrombin deficiency by heteroduplex screening

27 November 2018

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12 December 2020

Conformation of the reactive site loop of alpha 1-proteinase inhibitor probed by limited proteolysis

1 reference

12 December 2020

Effect of the Z mutation on the physical and inhibitory properties of alpha 1-antitrypsin

1 reference

12 December 2020

Probing the native strain iin alpha1-antitrypsin

1 reference

12 December 2020

Crystal structure of an uncleaved serpin reveals the conformation of an inhibitory reactive loop

1 reference

12 December 2020

Formation and properties of C1-inhibitor polymers

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12 December 2020

The serpin-proteinase complex revealed

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12 December 2020

Identifiers

DOI

10.1110/PS.9.7.1274

1 reference

release_zkn534xshzevdbjmkpgaaounfq

Fatcat ID

0 references

1 reference

1 reference

PubMed publication ID

10933492

1 reference