TFIIH complex serine/threonine-protein kinase subunit KIN28 YDL108W (Q27551001)

Cyclin-dependent kinase 7

1 reference

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

1 reference

25 May 2022

cyclin-dependent protein kinase activating kinase activity

KIN28 encodes a C-terminal domain kinase that controls mRNA transcription in Saccharomyces cerevisiae but lacks cyclin-dependent kinase-activating kinase (CAK) activity

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

14 February 2019

KIN28 encodes a C-terminal domain kinase that controls mRNA transcription in Saccharomyces cerevisiae but lacks cyclin-dependent kinase-activating kinase (CAK) activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

1 reference

14 February 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

1 reference

14 February 2019

transferase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

1 reference

14 February 2019

protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

1 reference

14 February 2019

RNA polymerase II CTD heptapeptide repeat kinase activity

Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

14 February 2019

14 February 2019

Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

14 February 2019

KIN28 encodes a C-terminal domain kinase that controls mRNA transcription in Saccharomyces cerevisiae but lacks cyclin-dependent kinase-activating kinase (CAK) activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06242&geneProductId=UniProtKB:P06242

1 reference

7 November 2018

protein binding

5 references

14 February 2019

A global protein kinase and phosphatase interaction network in yeast.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

14 February 2019

Proteome survey reveals modularity of the yeast cell machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

14 February 2019

Functional organization of the yeast proteome by systematic analysis of protein complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

14 February 2019

The kin28 protein kinase is associated with a cyclin in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

14 February 2019

Architecture of the Human and Yeast General Transcription and DNA Repair Factor TFIIH

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

cyclin-dependent protein serine/threonine kinase activity

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

cell component

cytosol

1 reference

14 February 2019

The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

transcription factor TFIIH holo complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

3 references

14 February 2019

14 February 2019

Function of Conserved Topological Regions within the Saccharomyces cerevisiae Basal Transcription Factor TFIIH

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

14 February 2019

Improved methods for expression and purification of Saccharomyces cerevisiae TFIIF and TFIIH; identification of a functional Escherichia coli promoter and internal translation initiation within the N-terminal coding region of the TFIIF TFG1 subunit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

transcription factor TFIIK complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06242&geneProductId=UniProtKB:P06242

3 references

21 June 2018

21 June 2018

Kin28 is found within TFIIH and a Kin28-Ccl1-Tfb3 trimer complex with differential sensitivities to T-loop phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06242&geneProductId=UniProtKB:P06242

21 June 2018

Improved methods for expression and purification of Saccharomyces cerevisiae TFIIF and TFIIH; identification of a functional Escherichia coli promoter and internal translation initiation within the N-terminal coding region of the TFIIF TFG1 subunit

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06242&geneProductId=UniProtKB:P06242

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

3 references

14 February 2019

14 February 2019

The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

cytoplasm

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

transcription factor TFIIK complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

4 references

14 February 2019

14 February 2019

Kin28 is found within TFIIH and a Kin28-Ccl1-Tfb3 trimer complex with differential sensitivities to T-loop phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

14 February 2019

Improved methods for expression and purification of Saccharomyces cerevisiae TFIIF and TFIIH; identification of a functional Escherichia coli promoter and internal translation initiation within the N-terminal coding region of the TFIIF TFG1 subunit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

transcription by RNA polymerase I

biological process

1 reference

14 February 2019

TFIIH plays an essential role in RNA polymerase I transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06242&geneProductId=UniProtKB:P06242

1 reference

21 June 2018

7-methylguanosine mRNA capping

1 reference

14 February 2019

Cdc28 kinase activity regulates the basal transcription machinery at a subset of genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

positive regulation of transcription by RNA polymerase II

1 reference

21 June 2018

Two cyclin-dependent kinases promote RNA polymerase II transcription and formation of the scaffold complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06242&geneProductId=UniProtKB:P06242

cell division

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

1 reference

14 February 2019

cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

1 reference

14 February 2019

transcription by RNA polymerase II

The KIN28 gene is required both for RNA polymerase II mediated transcription and phosphorylation of the Rpb1p CTD.

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

14 February 2019

KIN28 encodes a C-terminal domain kinase that controls mRNA transcription in Saccharomyces cerevisiae but lacks cyclin-dependent kinase-activating kinase (CAK) activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

14 February 2019

Improved methods for expression and purification of Saccharomyces cerevisiae TFIIF and TFIIH; identification of a functional Escherichia coli promoter and internal translation initiation within the N-terminal coding region of the TFIIF TFG1 subunit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

phosphorylation of RNA polymerase II C-terminal domain

Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

14 February 2019

KIN28 encodes a C-terminal domain kinase that controls mRNA transcription in Saccharomyces cerevisiae but lacks cyclin-dependent kinase-activating kinase (CAK) activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

14 February 2019

Phosphorylation of the yeast Rpb1 C-terminal domain at serines 2, 5, and 7.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

14 February 2019

Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

14 February 2019

TFIIH kinase places bivalent marks on the carboxy-terminal domain of RNA polymerase II.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

14 February 2019

Kin28 is found within TFIIH and a Kin28-Ccl1-Tfb3 trimer complex with differential sensitivities to T-loop phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex

2 references

14 February 2019

Phosphorylation of the RNA polymerase II C-terminal domain by TFIIH kinase is not essential for transcription of Saccharomyces cerevisiae genome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

14 February 2019

Kin28, the TFIIH-associated carboxy-terminal domain kinase, facilitates the recruitment of mRNA processing machinery to RNA polymerase II.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

phosphorylation of RNA polymerase II C-terminal domain involved in recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex

Kin28, the TFIIH-associated carboxy-terminal domain kinase, facilitates the recruitment of mRNA processing machinery to RNA polymerase II.

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

14 February 2019

Kin28, the TFIIH-associated carboxy-terminal domain kinase, facilitates the recruitment of mRNA processing machinery to RNA polymerase II.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

1 reference

14 February 2019

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06242&geneProductId=UniProtKB:P06242

1 reference

21 June 2018

protein phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06242&geneProductId=UniProtKB:P06242

1 reference

21 June 2018

regulation of cell cycle

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter

1 reference

14 February 2019

Engineered Covalent Inactivation of TFIIH-Kinase Reveals an Elongation Checkpoint and Results in Widespread mRNA Stabilization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

positive regulation of Atg1/ULK1 kinase complex assembly

1 reference

14 February 2019

The Ccl1-Kin28 kinase complex regulates autophagy under nitrogen starvation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

positive regulation of cyclin-dependent protein kinase activity

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

positive regulation of transcription by RNA polymerase II

protein phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

3 references

14 February 2019

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

14 February 2019

Global analysis of protein phosphorylation in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06242

serine/threonine-protein kinase, active site

HDA

has part(s)

1 reference

protein kinase domain

1 reference

protein kinase, ATP binding site

1 reference

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference