Regulation of brain iron and copper homeostasis by brain barrier systems: Implication in neurodegenerative diseases (Q26827257)

Regulation of brain iron and copper homeostasis by brain barrier systems: Implication in neurodegenerative diseases (English)

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https://api.crossref.org/works/10.1016/J.PHARMTHERA.2011.10.006

18 December 2024

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1 reference

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Wei Zheng

1

1 reference

Andrew D. Monnot

series ordinal

2

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language of work or name

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February 2012

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13 November 2011

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A22115751

full work available at URL

18 December 2024

https://europepmc.org/articles/pmc3268876?pdf=render

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A22115751

https://europepmc.org/articles/PMC3268876

18 December 2024

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A22115751

https://europepmc.org/articles/PMC3268876?pdf=render

18 December 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A22115751

https://doi.org/10.1016/j.pharmthera.2011.10.006

18 December 2024

online access status

open access

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A22115751

https://api.elsevier.com/content/article/PII:S0163725811002014?httpAccept=text/xml

18 December 2024

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2011.10.006

https://api.elsevier.com/content/article/PII:S0163725811002014?httpAccept=text/plain

18 December 2024

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2011.10.006

Pharmacology & Therapeutics

18 December 2024

published in

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volume

133

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issue

2

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page(s)

177-88

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Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples

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Efflux of iron from the cerebrospinal fluid to the blood at the blood-CSF barrier: effect of manganese exposure

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Intracellular localization and subsequent redistribution of metal transporters in a rat choroid plexus model following exposure to manganese or iron

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Gene chip analyses reveal differential genetic responses to iron deficiency in rat duodenum and jejunum

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Copper deficiency induces the upregulation of the copper chaperone for Cu/Zn superoxide dismutase in weanling male rats

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Copper stimulates endocytosis of the prion protein

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A pineal regulatory element (PIRE) mediates transactivation by the pineal/retina-specific transcription factor CRX

19 March 2017

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Iron, brain ageing and neurodegenerative disorders

19 March 2017

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

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Infectious prion protein alters manganese transport and neurotoxicity in a cell culture model of prion disease

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Molecular biology of the blood-brain and the blood-cerebrospinal fluid barriers: similarities and differences

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Regulation of brain copper homeostasis by the brain barrier systems: Effects of Fe-overload and Fe-deficiency

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Metal trafficking: from maintaining the metal homeostasis to future drug design

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Copper handling machinery of the brain

28 September 2017

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Brain iron metabolism and its perturbation in neurological diseases.

28 September 2017

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Manganese upregulates cellular prion protein and contributes to altered stabilization and proteolysis: relevance to role of metals in pathogenesis of prion disease

28 September 2017

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Brain iron homeostasis, the choroid plexus, and localization of iron transport proteins.

28 September 2017

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28 September 2017

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Iron trafficking inside the brain

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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The role of iron regulatory proteins in mammalian iron homeostasis and disease

28 September 2017

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Copper homeostasis and neurodegenerative disorders (Alzheimer's, prion, and Parkinson's diseases and amyotrophic lateral sclerosis).

28 September 2017

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Upregulation of DMT1 expression in choroidal epithelia of the blood-CSF barrier following manganese exposure in vitro

28 September 2017

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Molecular mechanism of distorted iron regulation in the blood-CSF barrier and regional blood-brain barrier following in vivo subchronic manganese exposure

28 September 2017

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Copper transport protein (Ctr1) levels in mice are tissue specific and dependent on copper status

28 September 2017

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The choroid plexus removes beta-amyloid from brain cerebrospinal fluid

28 September 2017

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Alteration at translational but not transcriptional level of transferrin receptor expression following manganese exposure at the blood-CSF barrier in vitro

28 September 2017

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28 September 2017

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Iron, copper and fetal development

28 September 2017

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Iron nutrition in the UK: getting the balance right

28 September 2017

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Alteration of serum concentrations of manganese, iron, ferritin, and transferrin receptor following exposure to welding fumes among career welders

28 September 2017

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28 September 2017

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The relevance of iron in the pathogenesis of Parkinson's disease.

28 September 2017

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Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain.

28 September 2017

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28 September 2017

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28 September 2017

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Brain barrier systems: a new frontier in metal neurotoxicological research

28 September 2017

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Trace amounts of copper in water induce beta-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease

28 September 2017

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Iron interactions and other biological reactions mediating the physiological and toxic actions of manganese

28 September 2017

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28 September 2017

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Function and regulation of the mammalian copper-transporting ATPases: insights from biochemical and cell biological approaches

28 September 2017

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Developmental changes in the expression of iron regulatory proteins and iron transport proteins in the perinatal rat brain

28 September 2017

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Copper homeostasis: the role of cellular transporters

28 September 2017

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28 September 2017

Copper and prion disease

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Essential role for mammalian copper transporter Ctr1 in copper homeostasis and embryonic development

28 September 2017

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Alteration of iron homeostasis following chronic exposure to manganese in rats

28 September 2017

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Copper biochemistry and molecular biology

28 September 2017

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An approach to study of transport of trace metals at the blood-brain barrier

28 September 2017

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Increased iron in the substantia nigra of 6-OHDA induced parkinsonian rats: a nuclear microscopy study

28 September 2017

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Identification and characterization of a second mouse Nramp gene

31 May 2018

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Increased nigral iron content in postmortem parkinsonian brain

31 May 2018

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Comparison of in vitro and in vivo models of drug transcytosis through the blood-brain barrier

31 May 2018

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A morphometric study on the development of the lateral ventricle choroid plexus, choroid plexus capillaries and ventricular ependyma in the rat.

31 May 2018

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Binding to cellular receptors results in increased iron release from transferrin at mildly acidic pH.

31 May 2018

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Localization of metallothionein in the brain of rat and mouse

31 May 2018

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Histochemical distribution of non-haem iron in the human brain

31 May 2018

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Regional distribution of copper, zinc and iron in the brain in Long-Evans Cinnamon (LEC) rats with a new mutation causing hereditary hepatitis

31 May 2018

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Transient expression of iron transport proteins in the capillary of the developing rat brain

31 May 2018

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Is cognitive function linked to serum free copper levels? A cohort study in a normal population.

28 November 2018

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Altered iron metabolism is part of the choroid plexus response to peripheral inflammation

28 November 2018

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Speciation analysis of selected metals and determination of their total contents in paired serum and cerebrospinal fluid samples: An approach to investigate the permeability of the human blood-cerebrospinal fluid-barrier

28 November 2018

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Separation of proteins including metallothionein in cerebrospinal fluid by size exclusion HPLC and determination of trace elements by HR-ICP-MS.

28 November 2018

1 reference

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Ferroportin in the postnatal rat brain: implications for axonal transport and neuronal export of iron

28 November 2018

1 reference

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Brain capillary endothelial cells mediate iron transport into the brain by segregating iron from transferrin without the involvement of divalent metal transporter 1.

28 November 2018

1 reference

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Downregulation of myelination, energy, and translational genes in Menkes disease brain

28 November 2018

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Distribution of divalent metal transporter-1 in the monkey basal ganglia

28 November 2018

1 reference

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Ion channels in epithelial cells of the choroid plexus isolated from the lateral ventricle of rat brain

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268876

Neurodegenerative diseases and oxidative stress

28 November 2018

1 reference

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Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

28 November 2018

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Copper repletion enhances apical iron uptake and transepithelial iron transport by Caco-2 cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268876

Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268876

Therapeutic benefit of polyamine-modified catalase as a scavenger of hydrogen peroxide and nitric oxide in familial amyotrophic lateral sclerosis transgenics

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268876

Effect of lead exposure and accumulation on copper homeostasis in cultured C6 rat glioma cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268876

Expression of copper trafficking genes in the mouse brain

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268876

Time-dependent changes in iron levels and associated neuronal loss within the substantia nigra following lesions within the neostriatum/globus pallidus complex

28 November 2018

1 reference

12 December 2020

Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain

1 reference

12 December 2020

Post-transcriptional expression of DMT1 in the heart of rat

1 reference

12 December 2020

CSF copper concentrations, blood-brain barrier function, and coeruloplasmin synthesis during the treatment of Wilson's disease

1 reference

12 December 2020

Differential localization of divalent metal transporter 1 with and without iron response element in rat PC12 and sympathetic neuronal cells

1 reference

12 December 2020

A new role for the transferrin receptor in the release of iron from transferrin

1 reference

12 December 2020

1 reference

12 December 2020

Histochemical localization of copper in various organs of brindled mice after copper therapy

1 reference

12 December 2020

Trace and major elements in whole blood, serum, cerebrospinal fluid and urine of patients with Parkinson's disease

1 reference

12 December 2020

Decrease in Cu/Zn- and Mn-superoxide dismutase activities in brain and spinal cord of patients with amyotrophic lateral sclerosis

1 reference

12 December 2020

Cellular localization of divalent metal transporter DMT-1 in rat kidney

1 reference

12 December 2020

Iron and copper interact during their uptake and deposition in the brain and other organs of developing rats exposed to dietary excess of the two metals

1 reference

12 December 2020

Abnormal mRNA splicing resulting from consensus sequence splicing mutations of ATP7B

1 reference

12 December 2020

Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat

1 reference

12 December 2020

Structure and dynamics of the iron responsive element RNA: implications for binding of the RNA by iron regulatory binding proteins

1 reference

https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2011.10.006

7 January 2021

Evidence for ceruloplasmin as a copper transport protein

1 reference

https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2011.10.006

7 January 2021

Electrophoretic separation of complexes involved in the splicing of precursors to mRNAs

1 reference

https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2011.10.006

7 January 2021

Regulating the fate of mRNA: the control of cellular iron metabolism

1 reference

https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2011.10.006

7 January 2021

Circulating ceruloplasmin is an important source of copper for normal and malignant animal cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2011.10.006

7 January 2021

Transferrin is required for normal distribution of 59Fe and 54Mn in mouse brain

1 reference

https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2011.10.006

7 January 2021

Influence of iron-saturation of plasma transferrin in iron distribution in the brain

1 reference

https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2011.10.006

7 January 2021

The iron transporter DMT1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2011.10.006

7 January 2021

Specific receptor for ceruloplasmin in membrane fragments from aortic and heart tissues

1 reference

https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2011.10.006

7 January 2021

Transferrin receptor on endothelium of brain capillaries

1 reference

https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2011.10.006

7 January 2021

Transport of Iron in the Blood‐Brain‐Cerebrospinal Fluid System

1 reference

https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2011.10.006

7 January 2021

Copper transport and metabolism are normal in aceruloplasminemic mice

1 reference

https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2011.10.006

7 January 2021

Novel Roles for Iron Regulatory Proteins in the Adaptive Response to Iron Deficiency

1 reference

https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2011.10.006

7 January 2021

Rate of 59Fe uptake into brain and cerebrospinal fluid and the influence thereon of antibodies against the transferrin receptor

1 reference

https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2011.10.006

7 January 2021

Copper Homeostasis: The Role of Cellular Transporters

1 reference

https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2011.10.006

7 January 2021

Iron status and neural functioning

1 reference

https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2011.10.006

7 January 2021

Albumin gene expression is down-regulated by albumin or macromolecule infusion in the rat

1 reference

https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2011.10.006

7 January 2021

Copper transport in the Nagase analbuminemic rat

series ordinal

109

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2011.10.006

18 December 2024

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1 reference

1 reference

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1 reference