Potential Renoprotective Agents through Inhibiting CTGF/CCN2 in Diabetic Nephropathy (Q26784039)

2

0 references

Chunguang Li

3

0 references

Wenpeng Cui

4

0 references

Lining Miao

Journal of Diabetes Research

5

0 references

language of work or name

English

0 references

publication date

2 September 2015

8 references

14 March 2019

24 March 2019

9 October 2019

20 November 2019

21 December 2019

29 May 2020

31 August 2020

18 November 2020

9 references

14 March 2019

24 March 2019

9 October 2019

20 November 2019

21 December 2019

29 May 2020

31 August 2020

18 November 2020

2015

0 references

page(s)

962383

0 references

copyright license

Creative Commons Attribution 3.0 Unported

8 references

14 March 2019

24 March 2019

9 October 2019

20 November 2019

21 December 2019

29 May 2020

31 August 2020

on focus list of Wikimedia project

18 November 2020

copyright status

copyrighted

0 references

ScienceSource

0 references

cites work

Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Angiotensin II induces connective tissue growth factor and collagen I expression via transforming growth factor-beta-dependent and -independent Smad pathways: the role of Smad3

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

RhoA/Rho-kinase contribute to the pathogenesis of diabetic renal disease

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

The Rho-kinase inhibitor, fasudil, attenuates diabetic nephropathy in streptozotocin-induced diabetic rats

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Effect of spironolactone on diabetic nephropathy compared to the combination of spironolactone and losartan

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Protective effect of statin therapy on connective tissue growth factor induction by diabetes in vivo and high glucose in vitro.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Targeting connective tissue growth factor (CTGF) in acute lymphoblastic leukemia preclinical models: anti-CTGF monoclonal antibody attenuates leukemia growth

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Effects of glucagon-like peptide-1 receptor agonists on renal function

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

CTGF is a therapeutic target for metastatic melanoma.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Aberrant activation of the intrarenal renin-angiotensin system in the developing kidneys of type 2 diabetic rats.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Statins impair glucose uptake in tumor cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Fluorofenidone suppresses epithelial-mesenchymal transition and the expression of connective tissue growth factor via inhibiting TGF-beta/Smads signaling in human proximal tubular epithelial cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

CCN-2 is up-regulated by and mediates effects of matrix bound advanced glycated end-products in human renal mesangial cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Connective tissue growth factor (CTGF/CCN2) ELISA: a novel tool for monitoring fibrosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Renal (pro)renin receptor contributes to development of diabetic kidney disease through transforming growth factor-β1-connective tissue growth factor signalling cascade

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Phase 1 study of anti-CTGF monoclonal antibody in patients with diabetes and microalbuminuria

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Regulation of (pro)renin receptor expression by glucose-induced mitogen-activated protein kinase, nuclear factor-kappaB, and activator protein-1 signaling pathways

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Advanced glycation end-products induce tubular CTGF via TGF-beta-independent Smad3 signaling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

(Pro)renin receptor contributes to diabetic nephropathy by enhancing renal inflammation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

CTGF and chronic kidney fibrosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

CTGF promotes inflammatory cell infiltration of the renal interstitium by activating NF-kappaB.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

BMP signaling and podocyte markers are decreased in human diabetic nephropathy in association with CTGF overexpression

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Simvastatin, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, suppresses osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand through modulation of NF-kappaB pathway.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Renal (pro)renin receptor upregulation in diabetic rats through enhanced angiotensin AT1 receptor and NADPH oxidase activity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Cost-effectiveness of losartan in diabetic nephropathy: a Greek perspective.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

The role of tubular epithelial-mesenchymal transition in progressive kidney disease.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Connective tissue growth factor plays an important role in advanced glycation end product-induced tubular epithelial-to-mesenchymal transition: implications for diabetic renal disease.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Influence of connective tissue growth factor antisense oligonucleotide on angiotensin II-induced epithelial mesenchymal transition in HK2 cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

The biology of incretin hormones

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Glucagon-like peptide-1: from extract to agent. The Claude Bernard Lecture, 2005.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Temporal expression profile and distribution pattern indicate a role of connective tissue growth factor (CTGF/CCN-2) in diabetic nephropathy in mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Hypoxic regulation of stability of connective tissue growth factor/CCN2 mRNA by 3'-untranslated region interacting with a cellular protein in human chondrosarcoma cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Are 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors renoprotective?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Individual domains of connective tissue growth factor regulate fibroblast proliferation and myofibroblast differentiation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Randomized trial of an inhibitor of formation of advanced glycation end products in diabetic nephropathy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Dietary cyanidin 3-O-beta-D-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/ p21 signaling pathway: Implications for diabetic nephropathy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Connective tissue growth factor: potential role in glomerulosclerosis and tubulointerstitial fibrosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Connective tissue growth factor: just another factor in renal fibrosis?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Angiotensin II-induced hypertrophy of cultured murine proximal tubular cells is mediated by endogenous transforming growth factor-beta

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Antidiabetic and Beta cell-protection activities of purple corn anthocyanins

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Effects of simvastatin on expression of CTGF and α-SMA in renal tubulointerstitium of rats with diabetic nephropathy

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

BCL-2: pro-or anti-oxidant?

31 May 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F962383

Connective tissue growth factor mediates high glucose effects on matrix degradation through tissue inhibitor of matrix metalloproteinase type 1: implications for diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F962383

A critical look at growth factors and epithelial-to-mesenchymal transition in the adult kidney. Interrelationships between growth factors that regulate EMT in the adult kidney.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F962383

Reduction in connective tissue growth factor by antisense treatment ameliorates renal tubulointerstitial fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F962383

Connective tissue growth factor inhibition attenuates left ventricular remodeling and dysfunction in pressure overload-induced heart failure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F962383

Connective tissue growth factor-mediated angiotensin II-induced hypertrophy of proximal tubular cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F962383

Irbesartan ameliorates diabetic nephropathy by reducing the expression of connective tissue growth factor and alpha-smooth-muscle actin in the tubulointerstitium of diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F962383

Reduction of urinary connective tissue growth factor by Losartan in type 1 patients with diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F962383

Mineralocorticoid Blockade Reduces Vascular Injury in Stroke-Prone Hypertensive Rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F962383

Effectiveness of aldosterone blockade in patients with diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F962383

Evaluation of spironolactone plus hydrochlorothiazide in reducing proteinuria in type 2 diabetic nephropathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F962383

Targeting of RhoA/ROCK signaling ameliorates progression of diabetic nephropathy independent of glucose control

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F962383

Rho kinase inhibition protects kidneys from diabetic nephropathy without reducing blood pressure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F962383

Mycophenolate mofetil prevents the development of glomerular injury in experimental diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F962383

Effects of mycophenolate mofetil on the expression of monocyte chemoattractant protein-1 and fibronectin in high glucose cultured human mesangial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F962383

Fluorofenidone attenuates renal interstitial fibrosis in the rat model of obstructive nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F962383

Fluorofenidone Attenuates Diabetic Nephropathy and Kidney Fibrosis in <i>db/db</i> Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F962383

Inhibition of the expression of TGF-β1 and CTGF in human mesangial cells by exendin-4, a glucagon-like peptide-1 receptor agonist.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F962383

Long-term treatment of glucagon-like peptide-1 analog exendin-4 ameliorates diabetic nephropathy through improving metabolic anomalies in db/db mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F962383

Pathogenesis, prevention, and treatment of diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F962383

Renal connective tissue growth factor induction in experimental diabetes is prevented by aminoguanidine

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F962383

Tranilast attenuates connective tissue growth factor-induced extracellular matrix accumulation in renal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F962383

The C-terminal module IV of connective tissue growth factor is a novel immune modulator of the Th17 response

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F962383

Connective Tissue Growth Factor Expressed in Tubular Epithelium Plays a Pivotal Role in Renal Fibrogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F962383

Involvement of Connective Tissue Growth Factor in Human and Experimental Hypertensive Nephrosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F962383

Fluorofenidone inhibits TGF-beta1 induced CTGF via MAPK pathways in mouse mesangial cells.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

The time has come to target connective tissue growth factor in diabetic complications

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4572424

Purple corn anthocyanins retard diabetes-associated glomerulosclerosis in mesangial cells and db/db mice

28 November 2018

1 reference

12 December 2020

Specific down-regulation of connective tissue growth factor attenuates progression of nephropathy in mouse models of type 1 and type 2 diabetes

1 reference

12 December 2020

Purple corn anthocyanins dampened high-glucose-induced mesangial fibrosis and inflammation: possible renoprotective role in diabetic nephropathy

1 reference

12 December 2020

Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice

1 reference

12 December 2020

Expression of connective tissue growth factor in human renal fibrosis

1 reference

12 December 2020

Spironolactone ameliorates renal injury and connective tissue growth factor expression in type II diabetic rats

1 reference

12 December 2020

Role of connective tissue growth factor in fibronectin expression and tubulointerstitial fibrosis

1 reference

12 December 2020

Intervention with tranilast attenuates renal pathology and albuminuria in advanced experimental diabetic nephropathy

1 reference

12 December 2020

Tranilast slows the progression of advanced diabetic nephropathy

1 reference

12 December 2020

Regression of nephropathy developed in diabetes by (Pro)renin receptor blockade

1 reference

12 December 2020

Integrated actions of transforming growth factor-beta1 and connective tissue growth factor in renal fibrosis

1 reference

12 December 2020

Localization of connective tissue growth factor in human uterine tissues

1 reference

12 December 2020

Effects of mycophenolic acid on high glucose-induced expression of TGF-beta and CTGF in mesangial cells

1 reference

12 December 2020

Spironolactone diminishes urinary albumin excretion in patients with type 1 diabetes and microalbuminuria: a randomized placebo-controlled crossover study

1 reference

12 December 2020

DNA damage by free radical production by aminoguanidine

1 reference

12 December 2020

The effect of fasudil via Rho/ROCK signaling pathway on the inflammation and fibrosis in human mesangial cells in high glucose medium

1 reference

12 December 2020