Epstein-Barr virus latent membrane protein 2A (LMP2A) employs the SLP-65 signaling module (Q24675538)

2

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R Pappu

3

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A C Chan

4

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R Longnecker

5

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J Wienands

Journal of Experimental Medicine

6

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language of work or name

English

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publication date

6 August 2001

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published in

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volume

194

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issue

3

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page(s)

255-64

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cites work

Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases

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SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation

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BLNK: a central linker protein in B cell activation

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Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G

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An Epstein-Barr virus transformation-associated membrane protein interacts with src family tyrosine kinases

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SH2 domains recognize specific phosphopeptide sequences

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Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65

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Requirement for B cell linker protein (BLNK) in B cell development

7 April 2017

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Interaction of SLP adaptors with the SH2 domain of Tec family kinases

7 April 2017

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Physiological signals and oncogenesis mediated through Crk family adapter proteins

7 April 2017

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BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells

7 April 2017

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BASH, a novel signaling molecule preferentially expressed in B cells of the bursa of Fabricius

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B cell antigen receptor signaling induces the formation of complexes containing the Crk adapter proteins

7 April 2017

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Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptors

7 April 2017

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p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase

7 April 2017

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Tyrosine-phosphorylated forms of Ig beta, CD22, TCR zeta and HOSS are major ligands for tandem SH2 domains of Syk

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The maintenance and the activation signal of the B-cell antigen receptor

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B cell development is arrested at the immature B cell stage in mice carrying a mutation in the cytoplasmic domain of immunoglobulin beta

28 September 2017

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Signal transduction elements of the B cell antigen receptor and their role in immunodeficiencies

28 September 2017

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The LMP2A ITAM is essential for providing B cells with development and survival signals in vivo

28 September 2017

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Lymphocyte signaling: Cbl sets the threshold for autoimmunity

28 September 2017

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The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells

28 September 2017

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28 September 2017

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The Epstein-Barr virus latent membrane protein 2A PY motif recruits WW domain-containing ubiquitin-protein ligases

28 September 2017

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BLNK: connecting Syk and Btk to calcium signals

28 September 2017

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The B-cell antigen receptor: formation of signaling complexes and the function of adaptor proteins

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28 September 2017

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Signal transduction from the B cell antigen-receptor

28 September 2017

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28 September 2017

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Induction of the antigen receptor expression on B lymphocytes results in rapid competence for signaling of SLP-65 and Syk.

28 September 2017

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Activation of the Rap1 GTPase by the B cell antigen receptor

28 September 2017

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Role of the adapter protein CRKL in signal transduction of normal hematopoietic and BCR/ABL-transformed cells

28 September 2017

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Regulation of Epstein-Barr virus latency by latent membrane protein 2.

28 September 2017

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Evidence for a preformed transducer complex organized by the B cell antigen receptor

28 September 2017

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28 September 2017

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An integral membrane protein (LMP2) blocks reactivation of Epstein-Barr virus from latency following surface immunoglobulin crosslinking

28 September 2017

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The (YXXL/I)2 signalling motif found in the cytoplasmic segments of the bovine leukaemia virus envelope protein and Epstein-Barr virus latent membrane protein 2A can elicit early and late lymphocyte activation events

28 September 2017

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Epstein-Barr virus latent membrane protein 2A blocks calcium mobilization in B lymphocytes

28 September 2017

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A second Epstein-Barr virus membrane protein (LMP2) is expressed in latent infection and colocalizes with LMP1.

28 September 2017

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An Epstein-Barr virus protein associated with cell growth transformation interacts with a tyrosine kinase

28 September 2017

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An EBV-Genome-Negative Cell Line Established from an American Burkitt Lymphoma; Receptor Characteristics. EBV Infectibility and Permanent Conversion into EBV-Positive Sublines by <i>in vitro</i> Infection

28 September 2017

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Defective B cell development and function in Btk-deficient mice

28 September 2017

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Antigen Receptor Signaling Gives Lymphocytes a Long Life

28 September 2017

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Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases

30 May 2018

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Impaired expansion of mouse B cell progenitors lacking Btk.

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In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.

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Epstein-Barr virus coopts lipid rafts to block the signaling and antigen transport functions of the BCR.

21 January 2018

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The Immunoreceptor Tyrosine-Based Activation Motif of Epstein–Barr Virus LMP2A Is Essential for Blocking BCR-Mediated Signal Transduction

21 January 2018

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Molecular mimicry of the antigen receptor signalling motif by transmembrane proteins of the Epstein-Barr virus and the bovine leukaemia virus.

21 January 2018

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Epstein-Barr virus LMP2A drives B cell development and survival in the absence of normal B cell receptor signals

21 January 2018

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GTPases in antigen receptor signalling

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Aberrant B Cell Development and Immune Response in Mice with a Compromised BCR Complex

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In vitro characterization of major ligands for Src homology 2 domains derived from protein tyrosine kinases, from the adaptor protein SHC and from GTPase-activating protein in Ramos B cells

21 January 2018

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12 December 2020

B cell development and activation defects resulting in xid-like immunodeficiency in BLNK/SLP-65-deficient mice

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12 December 2020

Maintenance of Human T Cell Anergy: Blocking of IL-2 Gene Transcription by Activated Rap1

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12 December 2020

Cutting edge: association of phospholipase C-gamma 2 Src homology 2 domains with BLNK is critical for B cell antigen receptor signaling

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12 December 2020