Multiple roles for emerin: implications for Emery-Dreifuss muscular dystrophy (Q24658156)

Emery-Dreifuss muscular dystrophy

Europe PubMed Central

title

Multiple roles for emerin: implications for Emery-Dreifuss muscular dystrophy (English)

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main subject

1 reference

James M Holaska

1

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Katherine L Wilson

series ordinal

2

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language of work or name

English

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publication date

July 2006

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published in

The Anatomical Record

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volume

288

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issue

7

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page(s)

676-80

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cites work

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Nesprin-2 is a multi-isomeric protein that binds lamin and emerin at the nuclear envelope and forms a subcellular network in skeletal muscle

7 April 2017

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Emerin caps the pointed end of actin filaments: evidence for an actin cortical network at the nuclear inner membrane

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Emerin binding to Btf, a death-promoting transcriptional repressor, is disrupted by a missense mutation that causes Emery-Dreifuss muscular dystrophy

7 April 2017

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Nesprin-1alpha self-associates and binds directly to emerin and lamin A in vitro

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Myne-1, a spectrin repeat transmembrane protein of the myocyte inner nuclear membrane, interacts with lamin A/C

7 April 2017

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MAN1, an inner nuclear membrane protein that shares the LEM domain with lamina-associated polypeptide 2 and emerin

7 April 2017

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Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy

7 April 2017

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The interaction and colocalization of Sam68 with the splicing-associated factor YT521-B in nuclear dots is regulated by the Src family kinase p59(fyn)

7 April 2017

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Emerin deficiency at the nuclear membrane in patients with Emery-Dreifuss muscular dystrophy

7 April 2017

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Emerin interacts in vitro with the splicing-associated factor, YT521-B

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7 April 2017

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Transcriptional repressor germ cell-less (GCL) and barrier to autointegration factor (BAF) compete for binding to emerin in vitro

7 April 2017

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Life at the edge: the nuclear envelope and human disease

7 April 2017

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BAF is required for emerin assembly into the reforming nuclear envelope

7 April 2017

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Distinct functional domains in emerin bind lamin A and DNA-bridging protein BAF

7 April 2017

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Emery-Dreifuss muscular dystrophy - a 40 year retrospective

7 April 2017

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7 April 2017

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Direct interaction between emerin and lamin A

7 April 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559942

The Emery-Dreifuss muscular dystrophy protein, emerin, is a nuclear membrane protein

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559942

Nuclear membrane protein LAP2beta mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less)

7 April 2017

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Nesprins: intracellular scaffolds that maintain cell architecture and coordinate cell function?

7 April 2017

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Nuclear envelopathies--raising the nuclear veil

28 September 2017

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28 September 2017

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Barrier-to-autointegration factor is required to segregate and enclose chromosomes within the nuclear envelope and assemble the nuclear lamina

28 September 2017

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The nuclear lamina comes of age.

28 September 2017

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Direct binding of nuclear membrane protein MAN1 to emerin in vitro and two modes of binding to barrier-to-autointegration factor

28 September 2017

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MAN1, an integral protein of the inner nuclear membrane, binds Smad2 and Smad3 and antagonizes transforming growth factor-beta signaling.

28 September 2017

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New roles for lamins, nuclear envelope proteins and actin in the nucleus

28 September 2017

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All in the family: evidence for four new LEM-domain proteins Lem2 (NET-25), Lem3, Lem4 and Lem5 in the human genome

28 September 2017

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Multiple and surprising new functions for emerin, a nuclear membrane protein

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559942

Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559942

108th ENMC International Workshop, 3rd Workshop of the MYO-CLUSTER project: EUROMEN, 7th International Emery-Dreifuss Muscular Dystrophy (EDMD) Workshop, 13-15 September 2002, Naarden, The Netherlands

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559942

MAN1 and emerin have overlapping function(s) essential for chromosome segregation and cell division in Caenorhabditis elegans

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559942

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28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559942

XMAN1, an inner nuclear membrane protein, antagonizes BMP signaling by interacting with Smad1 in Xenopus embryos

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559942

Actin in the nucleus: what form and what for?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559942

SANE, a novel LEM domain protein, regulates bone morphogenetic protein signaling through interaction with Smad1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559942

Barrier to autointegration factor interacts with the cone-rod homeobox and represses its transactivation function

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559942

The nuclear envelope, lamins and nuclear assembly.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559942

Transcriptional repression, apoptosis, human disease and the functional evolution of the nuclear lamina

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559942

C. elegans nuclear envelope proteins emerin, MAN1, lamin, and nucleoporins reveal unique timing of nuclear envelope breakdown during mitosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559942

The Emery-Dreifuss muscular dystrophy phenotype arises from aberrant targeting and binding of emerin at the inner nuclear membrane.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559942

Integration of a growth-suppressing BTB/POZ domain protein with the DP component of the E2F transcription factor

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559942

Dynamic interaction between BAF and emerin revealed by FRAP, FLIP, and FRET analyses in living HeLa cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559942

Nuclear envelope alterations in fibroblasts from LGMD1B patients carrying nonsense Y259X heterozygous or homozygous mutation in lamin A/C gene

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559942

CDNA microarray analysis of gene expression in fibroblasts of patients with X-linked Emery-Dreifuss muscular dystrophy

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559942

Increased solubility of lamins and redistribution of lamin C in X-linked Emery-Dreifuss muscular dystrophy fibroblasts

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16761279

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Colocalization of emerin and lamins in interphase nuclei and changes during mitosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16761279

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Architectural abnormalities in muscle nuclei. Ultrastructural differences between X-linked and autosomal dominant forms of EDMD

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16761279