Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates (Q24646644)

primates

1 reference

based on heuristic

inferred from title

author

Robert S. Langer, Jr.

28

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Hans-Peter Vornlocher

27

Hans-Peter Vornlocher

0 references

Ingo Röhl

20

Ingo Röhl

0 references

Victor E. Koteliansky

31

Victor Koteliansky

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Daniel G Anderson

29

Daniel G Anderson

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Maria Frank-Kamenetsky

1

Maria Frank-Kamenetsky

0 references

Timothy S Racie

4

Timothy S Racie

0 references

Akin Akinc

6

Akin Akinc

0 references

J Robert Dorkin

9

Robert Dorkin

0 references

Christina Gamba-Vitalo

11

Christina Gamba-Vitalo

0 references

Philipp Hadwiger

12

Philipp Hadwiger

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Muthusamy Jayaraman

13

K Narayanannair Jayaprakash

Muthusamy Jayaraman

0 references

15

K Narayanannair Jayaprakash

0 references

Lubomir Nechev

17

Kallanthottathil G Rajeev

Lubomir Nechev

0 references

18

Kallanthottathil G Rajeev

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Jürgen Soutschek

21

Jürgen Soutschek

0 references

Tracy S Zimmermann

25

Tracy Zimmermann

0 references

Antonin de Fougerolles

26

Antonin de Fougerolles

0 references

Muthiah Manoharan

30

Muthiah Manoharan

0 references

Jay D Horton

32

Jay D Horton

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author name string

Aldo Grefhorst

2

0 references

Norma N Anderson

3

0 references

Birgit Bramlage

5

0 references

David Butler

7

0 references

Klaus Charisse

8

0 references

Yupeng Fan

10

0 references

Matthias John

14

0 references

Martin Maier

16

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Timothy Read

19

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Pamela Tan

22

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Jamie Wong

23

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Gang Wang

24

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Kevin Fitzgerald

Proceedings of the National Academy of Sciences of the United States of America

33

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language of work or name

English

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publication date

19 August 2008

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published in

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volume

105

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issue

33

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page(s)

11915-20

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cites work

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Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype

7 April 2017

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The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

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Molecular biology of PCSK9: its role in LDL metabolism

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Mice heterozygous for a defect in mitochondrial trifunctional protein develop hepatic steatosis and insulin resistance

7 April 2017

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Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

7 April 2017

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Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice

7 April 2017

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Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9

7 April 2017

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Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

7 April 2017

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7 April 2017

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Plasma PCSK9 preferentially reduces liver LDL receptors in mice

27 September 2017

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Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway

27 September 2017

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Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9.

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Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver.

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27 September 2017

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27 September 2017

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Effect of lovastatin on the secretion of very low density lipoprotein lipids and apolipoprotein B in the hypertriglyceridemic Zucker obese rat.

27 September 2017

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Lipid-lowering activity of atorvastatin and lovastatin in rodent species: triglyceride-lowering in rats correlates with efficacy in LDL animal models

21 January 2018

1 reference

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Inhibition of microsomal triglyceride transfer protein: another mechanism for drug-induced steatosis in mice.

21 January 2018

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Effectiveness of ezetimibe alone or in combination with twice a week Atorvastatin (10 mg) for statin intolerant high-risk patients

21 January 2018

1 reference

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RNAi-mediated gene silencing in non-human primates.

21 January 2018

1 reference

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Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

28 November 2018

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28 November 2018

Identifiers

DOI

10.1073/PNAS.0805434105

1 reference

ADS bibcode

2008PNAS..10511915F

0 references

1 reference

1 reference

PubMed publication ID

18695239

1 reference