Translocator protein 18 kDa (TSPO): molecular sensor of brain injury and repair (Q24644752)

Pharmacology & Therapeutics

Europe PubMed Central

title

Translocator protein 18 kDa (TSPO): molecular sensor of brain injury and repair (English)

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Ming-Kai Chen

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Tomás R Guilarte

series ordinal

2

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language of work or name

English

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publication date

April 2008

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published in

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volume

118

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issue

1

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page(s)

1-17

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cites work

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Intracellular cholesterol changes induced by translocator protein (18 kDa) TSPO/PBR ligands

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Peripheral-type benzodiazepine receptor: structure and function of a cholesterol-binding protein in steroid and bile acid biosynthesis

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Identification, localization, and function in steroidogenesis of PAP7: a peripheral-type benzodiazepine receptor- and PKA (RIalpha)-associated protein

7 April 2017

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Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis

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The P2Y12 receptor regulates microglial activation by extracellular nucleotides

7 April 2017

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Regulation of the expression of peripheral benzodiazepine receptors and their endogenous ligands during rat sciatic nerve degeneration and regeneration: a role for PBR in neurosteroidogenesis

7 April 2017

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Isolation, characterization, and purification to homogeneity of an endogenous polypeptide with agonistic action on benzodiazepine receptors

7 April 2017

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ATP mediates rapid microglial response to local brain injury in vivo

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A comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: implications for PET imaging of microglial activation

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The peripheral benzodiazepine receptor (Translocator protein 18kDa) in microglia: from pathology to imaging

27 September 2017

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Development of ligands for the peripheral benzodiazepine receptor

27 September 2017

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Nuclear location-dependent role of peripheral benzodiazepine receptor (PBR) in hepatic tumoral cell lines proliferation

27 September 2017

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Ro5-4864, a peripheral benzodiazepine receptor ligand, reduces reactive gliosis and protects hippocampal hilar neurons from kainic acid excitotoxicity.

27 September 2017

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PET imaging of brain macrophages using the peripheral benzodiazepine receptor in a macaque model of neuroAIDS

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The myxoma poxvirus protein, M11L, prevents apoptosis by direct interaction with the mitochondrial permeability transition pore.

27 September 2017

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SSR180575 (7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide), a peripheral benzodiazepine receptor ligand, promotes neuronal survival and repair

27 September 2017

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Role of the peripheral-type benzodiazepine receptor in adrenal and brain steroidogenesis

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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Microglial response to brain injury: a brief synopsis

27 September 2017

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Peripheral-type benzodiazepine receptors in the regulation of proliferation of MCF-7 human breast carcinoma cell line

27 September 2017

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27 September 2017

Reactive microgliosis

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Peripheral-type benzodiazepine receptor (PBR) in human breast cancer: correlation of breast cancer cell aggressive phenotype with PBR expression, nuclear localization, and PBR-mediated cell proliferation and nuclear transport of cholesterol

27 September 2017

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Effects of Peripheral-type Benzodiazepine Receptor Antisense Knockout on MA-10 Leydig Cell Proliferation and Steroidogenesis

27 September 2017

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Quantitative features of reactive gliosis following toxicant-induced damage of the CNS.

27 September 2017

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The function of acyl-CoA-binding protein (ACBP)/diazepam binding inhibitor (DBI).

27 September 2017

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In vitro reconstitution of a functional peripheral-type benzodiazepine receptor from mouse Leydig tumor cells.

27 September 2017

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Mitochondrial benzodiazepine receptor linked to inner membrane ion channels by nanomolar actions of ligands

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27 September 2017

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Benzodiazepines that bind at peripheral sites inhibit cell proliferation

27 September 2017

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Receptors for the Age of Anxiety: Pharmacology of the Benzodiazepines

27 September 2017

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Porphyrins are endogenous ligands for the mitochondrial (peripheral-type) benzodiazepine receptor

27 September 2017

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27 September 2017

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The peripheral-type benzodiazepine receptor: a protein of mitochondrial outer membranes utilizing porphyrins as endogenous ligands

27 September 2017

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Identification of des-(Gly-Ile)-endozepine as an effector of corticotropin-dependent adrenal steroidogenesis: stimulation of cholesterol delivery is mediated by the peripheral benzodiazepine receptor

27 September 2017

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Peripheral type benzodiazepine receptors

27 September 2017

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Assessment of neurotoxicity: use of glial fibrillary acidic protein as a biomarker

27 September 2017

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Cloning and expression of a pharmacologically unique bovine peripheral-type benzodiazepine receptor isoquinoline binding protein

27 September 2017

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Quantitative aspects of reactive gliosis: a review

27 September 2017

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GABAergic modulation of benzodiazepine binding site sensitivity

27 September 2017

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Specific benzodiazepine receptors in rat brain characterized by high-affinity (3H)diazepam binding

27 September 2017

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Expression of mitochondrial benzodiazepine receptor and its putative endogenous ligand diazepam binding inhibitor in cultured primary astrocytes and C-6 cells: relation to cell growth.

27 September 2017

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VMAT2 and dopamine neuron loss in a primate model of Parkinson's disease

27 September 2017

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In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease

30 May 2018

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In vivo imaging of microglial activation with [11C](R)-PK11195 PET in progressive supranuclear palsy

30 May 2018

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In vivo imaging of microglial activation with [11C](R)-PK11195 PET in corticobasal degeneration

30 May 2018

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Imaging of activated microglia with PET and [11C]PK 11195 in corticobasal degeneration

30 May 2018

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Microglial response is poorly correlated with neurodegeneration following chronic, low-dose MPTP administration in monkeys

30 May 2018

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Semiquantification of the peripheral-type benzodiazepine ligand [11C]PK11195 in normal human brain and application in multiple sclerosis patients

30 May 2018

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Pathways of dehydroepiandrosterone formation in rat brain glia

30 May 2018

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Structure and Function of the Peripheral-Type Benzodiazepine Receptor in Steroidogenic Cells

30 May 2018

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PK11195 binding to the peripheral benzodiazepine receptor as a marker of microglia activation in multiple sclerosis and experimental autoimmune encephalomyelitis

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Increased expression of peripheral benzodiazepine receptors in the facial nucleus following motor neuron axotomy

30 May 2018

1 reference

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The peripheral benzodiazepine receptor is a sensitive indicator of domoic acid neurotoxicity

30 May 2018

1 reference

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Distribution profile and properties of peripheral-type benzodiazepine receptors on human hemopoietic cells

30 May 2018

1 reference

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Labelling of "Peripheral-Type" Benzodiazepine Binding Sites in the Rat Brain By Using [3H]PK 11195, an Isoquinoline Carboxamide Derivative: Kinetic Studies and Autoradiographic Localization

30 May 2018

1 reference

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Differentiation between two ligands for peripheral benzodiazepine binding sites, [3H]R05-4864 and [3H]PK 11195, by thermodynamic studies

30 May 2018

1 reference

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Peripheral benzodiazepine binding sites: Effect of PK 11195, 1-(2-chlorophenyl)-n-methyl-(1-methylpropyl)-3 isoquinolinecarboxamide

30 May 2018

1 reference

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Peripheral benzodiazepine binding sites: Effect of PK 11195, 1-(2-chlorophenyl)-n-methyl-n-(1-methylpropyl)-3-isoquinolinecarboxamide

30 May 2018

1 reference

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The peripheral-type benzodiazepine receptor. Localization to the mitochondrial outer membrane

30 May 2018

1 reference

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Late evolutionary appearance of 'peripheral-type' binding sites for benzodiazepines

30 May 2018

1 reference

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Peripheral type benzodiazepine binding sites are a sensitive indirect index of neuronal damage

30 May 2018

1 reference

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Isolation and characterization of a rat brain triakontatetraneuropeptide, a posttranslational product of diazepam binding inhibitor: specific action at the Ro 5-4864 recognition site

30 May 2018

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Systemic injection of kainic acid: gliosis in olfactory and limbic brain regions quantified with [3H]PK 11195 binding autoradiography

30 May 2018

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The quantification of brain lesions with an omega 3 site ligand: a critical analysis of animal models of cerebral ischaemia and neurodegeneration

30 May 2018

1 reference

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Distribution and characterization of diazepam binding inhibitor (DBI) in peripheral tissues of rat.

30 May 2018

1 reference

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Two subcellular locations for peripheral-type benzodiazepine acceptors in rat liver

30 May 2018

1 reference

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The peripheral-type benzodiazepine receptor is functionally linked to Leydig cell steroidogenesis.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Macrophage and astrocyte populations in relation to [3H]PK 11195 binding in rat cerebral cortex following a local ischaemic lesion

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Brain kinetics and specific binding of [11C]PK 11195 to omega 3 sites in baboons: positron emission tomography study.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Immunohistochemistry of diazepam binding inhibitor (DBI) in the central nervous system and peripheral organs: its possible role as an endogenous regulator of different types of benzodiazepine receptors

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Diazepam Binding Inhibitor and Its Processing Products Stimulate Mitochondrial Steroid Biosynthesis via an Interaction with Mitochondrial Benzodiazepine Receptors*

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Monitoring by PET of macrophage accumulation in brain after ischaemic stroke

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

In vivo imaging of brain lesions with [(11)C]CLINME, a new PET radioligand of peripheral benzodiazepine receptors.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Phase-dependent roles of reactive microglia and astrocytes in nervous system injury as delineated by imaging of peripheral benzodiazepine receptor

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Imaging brain inflammation with [(11)C]PK11195 by PET and induction of the peripheral-type benzodiazepine receptor after transient focal ischemia in rats

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

11C-DPA-713: a novel peripheral benzodiazepine receptor PET ligand for in vivo imaging of neuroinflammation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Microglial activation in presymptomatic Huntington's disease gene carriers

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Reference and target region modeling of [11C]-(R)-PK11195 brain studies

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Up-regulation of PK11195 binding in areas of axonal degeneration coincides with early microglial activation in mouse brain

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Microglial activation correlates with severity in Huntington disease: a clinical and PET study.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Intrinsic activated microglia map to the peri-infarct zone in the subacute phase of ischemic stroke.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Imaging the peripheral benzodiazepine receptor response in central nervous system demyelination and remyelination

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Mitochondrial ligand inhibits store-operated calcium influx and COX-2 production in human microglia

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Imaging glial cell activation with [11C]-R-PK11195 in patients with AIDS.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

High-affinity peripheral benzodiazepine receptor ligand, PK11195, regulates protein phosphorylation in rat brain mitochondria under control of Ca(2+).

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Synthesis and in vivo evaluation of a novel peripheral benzodiazepine receptor PET radioligand

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Evaluation of a radiolabelled peripheral benzodiazepine receptor ligand in the central nervous system inflammation of experimental autoimmune encephalomyelitis: a possible probe for imaging multiple sclerosis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Microglial imaging with positron emission tomography and atrophy measurements with magnetic resonance imaging in multiple sclerosis: a correlative study

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Development of a tracer kinetic plasma input model for (R)-[11C]PK11195 brain studies

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Microglial activation and dopamine terminal loss in early Parkinson's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

In vivo detection of microglial activation in frontotemporal dementia

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Novel peripheral benzodiazepine receptor ligand [11C]DAA1106 for PET: an imaging tool for glial cells in the brain

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Peripheral benzodiazepine receptor imaging in CNS demyelination: functional implications of anatomical and cellular localization

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Immunohistochemical assessment of the peripheral benzodiazepine receptor in human tissues

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Methamphetamine-induced deficits of brain monoaminergic neuronal markers: distal axotomy or neuronal plasticity

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Effects of peripheral benzodiazepine receptor ligands on proliferation and differentiation of human mesenchymal stem cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

[11C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Assessment of neuroinflammation and microglial activation in Alzheimer's disease with radiolabelled PK11195 and single photon emission computed tomography. A pilot study

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

PET visualization of microglia in multiple sclerosis patients using [11C]PK11195

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

The peripheral benzodiazepine receptor ligand PK11195 binds with high affinity to the acute phase reactant alpha1-acid glycoprotein: implications for the use of the ligand as a CNS inflammatory marker

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Elevated peripheral benzodiazepine receptor expression in simian immunodeficiency virus encephalitis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Inhibition of lipopolysaccharide-induced cyclooxygenase-2, tumor necrosis factor-alpha and [Ca2+]i responses in human microglia by the peripheral benzodiazepine receptor ligand PK11195.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

PK 11195 attenuates kainic acid-induced seizures and alterations in peripheral-type benzodiazepine receptor (PBR) protein components in the rat brain

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

In vivo visualization of activated glia by [11C] (R)-PK11195-PET following herpes encephalitis reveals projected neuronal damage beyond the primary focal lesion

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

In-vivo measurement of activated microglia in dementia

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Diazepam stimulates migration and phagocytosis of human neutrophils: possible contribution of peripheral-type benzodiazepine receptors and intracellular calcium

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Structural and functional study of reconstituted peripheral benzodiazepine receptor

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Up-regulation of the peripheral-type benzodiazepine receptor expression and [(3)H]PK11195 binding in gerbil hippocampus after transient forebrain ischemia

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Imaging cerebral vasculitis in refractory epilepsy using [(11)C](R)-PK11195 positron emission tomography

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Location-dependent role of the human glioma cell peripheral-type benzodiazepine receptor in proliferation and steroid biosynthesis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Modeling dynamic PET-SPECT studies in the wavelet domain

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

[11C](R)-PK11195 positron emission tomography imaging of activated microglia in vivo in Rasmussen's encephalitis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Neurosteroid progesterone is up-regulated in the brain of jimpy and shiverer mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Binding characteristics of [3H]DAA1106, a novel and selective ligand for peripheral benzodiazepine receptors

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Regional and temporal expression of the peripheral benzodiazepine receptor in MPTP neurotoxicity

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

GABA inhibits endozepine release from cultured rat astrocytes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Glial reaction in aging and Alzheimer's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

PK11195, a ligand of the mitochondrial benzodiazepine receptor, facilitates the induction of apoptosis and reverses Bcl-2-mediated cytoprotection.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Increased peripheral benzodiazepine binding sites in the brain of patients with Huntington's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Simplified reference tissue model for PET receptor studies.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Chronological study of peripheral benzodiazepine binding sites in the rat brain stab wounds using [3H] PK-11195 as a marker for gliosis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

The endogenous benzodiazepine receptor ligand ODN increases cytosolic calcium in cultured rat astrocytes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Ontogeny of diazepam-binding inhibitor-related peptides (endozepines) in the rat brain.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Mitochondrial benzodiazepine receptors mediate inhibition of mitochondrial respiratory control

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453598

Specific high-affinity saturable binding of [3H] R05-4864 to benzodiazepine binding sites in the rat cerebral cortex

28 November 2018

1 reference

12 December 2020

"Peripheral type" benzodiazepine binding sites in rat adrenals: binding studies with [3H]PK 11195 and autoradiographic localization

1 reference

12 December 2020

Benzodiazepine receptor-mediated chemotaxis of human monocytes

1 reference

12 December 2020

In vivo immunomodulating activity of PK 1195, a structurally unrelated ligand for "peripheral" benzodiazepine binding sites--I. Potentiation in mice of the humoral response to sheep red blood cells

1 reference

12 December 2020

A 3D model of the peripheral benzodiazepine receptor and its implication in intra mitochondrial cholesterol transport

1 reference

12 December 2020

Topography of the Leydig cell mitochondrial peripheral-type benzodiazepine receptor

1 reference

12 December 2020

Peripheral benzodiazepine receptors are colocalized with activated microglia following transient global forebrain ischemia in the rat

1 reference

12 December 2020

Enhanced expression of peripheral benzodiazepine receptors in trimethyltin-exposed rat brain: a biomarker of neurotoxicity

1 reference

12 December 2020

Two cellular and subcellular locations for the peripheral-type benzodiazepine receptor in rat liver

1 reference

12 December 2020

Differential activation of microglia and astrocytes following trimethyl tin-induced neurodegeneration

1 reference

12 December 2020

Synthesis and biology of a 7-nitro-2,1,3-benzoxadiazol-4-yl derivative of 2-phenylindole-3-acetamide: a fluorescent probe for the peripheral-type benzodiazepine receptor

1 reference

12 December 2020

Topological Analysis of the Peripheral Benzodiazepine Receptor in Yeast Mitochondrial Membranes Supports a Five-transmembrane Structure

1 reference

12 December 2020

Pathways of neurosteroid biosynthesis in cell lines from human brain: regulation of dehydroepiandrosterone formation by oxidative stress and beta-amyloid peptide

1 reference

12 December 2020

Traumatic brain injury leads to increased expression of peripheral-type benzodiazepine receptors, neuronal death, and activation of astrocytes and microglia in rat thalamus

1 reference

12 December 2020

Cellular and subcellular localization of peripheral benzodiazepine receptors after trimethyltin neurotoxicity

1 reference

12 December 2020

Diazepam-binding inhibitor-derived peptides induce intracellular calcium changes and modulate human neutrophil function

1 reference

12 December 2020

Evolution of microglial activation in patients after ischemic stroke: a [11C](R)-PK11195 PET study

1 reference

12 December 2020

In vivo imaging of activated microglia using [11C]PK11195 and positron emission tomography in patients after ischemic stroke

1 reference

12 December 2020

The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity

1 reference

12 December 2020

Anti-inflammatory effects of peripheral benzodiazepine receptor ligands in two mouse models of inflammation

1 reference

12 December 2020

Microglial cell population dynamics in the injured adult central nervous system

1 reference

12 December 2020

Molecular characterization and mitochondrial density of a recognition site for peripheral-type benzodiazepine ligands

1 reference

12 December 2020

Presence of peripheral-type benzodiazepine binding sites on human erythrocyte membranes

1 reference

12 December 2020

Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function

1 reference

12 December 2020

Effect of 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinoline carboxamide (PK11195), a specific ligand of the peripheral benzodiazepine receptor, on the lipid fluidity of mitochondria in human glioma cells

1 reference

12 December 2020

Acyl-CoA-binding and transport, an alternative function for diazepam binding inhibitor (DBI), which is identical with acyl-CoA-binding protein

1 reference

12 December 2020

Molecular basis for the different binding properties of benzodiazepines to human and bovine peripheral-type benzodiazepine receptors

1 reference

12 December 2020

PK ('peripheral benzodiazepine')--binding sites in the CNS indicate early and discrete brain lesions: microautoradiographic detection of [3H]PK11195 binding to activated microglia

1 reference

12 December 2020

GABA inhibits endozepine release from cultured rat astrocytes

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2007.12.004

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1016/J.PHARMTHERA.2007.12.004

1 reference

1 reference

1 reference

PubMed publication ID

18374421

1 reference