FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor (Q24632191)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20412774%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

title

FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor (English)

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31 January 2020

2

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31 January 2020

Deepa Sundararajan

5

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31 January 2020

author name string

Chia-Chen Chen

1

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31 January 2020

Prashanth T Bhaskar

3

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31 January 2020

Veronique Nogueira

4

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31 January 2020

Ivana Tonic

6

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31 January 2020

Youngkyu Park

7

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31 January 2020

Nissim Hay

8

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31 January 2020

language of work or name

English

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publication date

1 April 2010

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31 January 2020

number of pages

13

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based on heuristic

inferred from page(s)

published in

Developmental Cell

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31 January 2020

volume

18

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issue

4

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31 January 2020

page(s)

592-604

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Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

31 January 2020

cites work

1 reference

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

7 April 2017

1 reference

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

7 April 2017

1 reference

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A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span

7 April 2017

1 reference

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

7 April 2017

1 reference

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

7 April 2017

1 reference

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Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

7 April 2017

1 reference

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TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver

7 April 2017

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

7 April 2017

1 reference

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Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation

7 April 2017

1 reference

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TSC2 mediates cellular energy response to control cell growth and survival

7 April 2017

1 reference

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p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

7 April 2017

1 reference

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

7 April 2017

1 reference

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Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

7 April 2017

1 reference

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The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span

7 April 2017

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The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

7 April 2017

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FoxO3 controls autophagy in skeletal muscle in vivo

7 April 2017

1 reference

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FOXO transcription factors at the interface between longevity and tumor suppression

7 April 2017

1 reference

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Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy

7 April 2017

1 reference

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KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity

7 April 2017

1 reference

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A new player in the orchestra of cell growth: SREBP activity is regulated by mTORC1 and contributes to the regulation of cell and organ size

27 September 2017

1 reference

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Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb

27 September 2017

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27 September 2017

The two TORCs and Akt.

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mTOR, translation initiation and cancer

27 September 2017

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Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism

27 September 2017

1 reference

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Atrophy of S6K1(-/-) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control.

27 September 2017

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FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK.

27 September 2017

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TOR pathway: linking nutrient sensing to life span

27 September 2017

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Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

27 September 2017

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Redox regulation of PI 3-kinase signalling via inactivation of PTEN

27 September 2017

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Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway

27 September 2017

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Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis

27 September 2017

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mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes

30 May 2018

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Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity

28 November 2018

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The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

28 November 2018

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Negative regulation of the forkhead transcription factor FKHR by Akt.

28 November 2018

1 reference

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Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies

28 November 2018

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2010.03.008

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7 January 2021

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Identifiers

DOI

10.1016/J.DEVCEL.2010.03.008

2 references

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31 January 2020

1 reference

2 references

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31 January 2020

PubMed publication ID

20412774

2 references