Mechanisms of acetaminophen-induced liver necrosis (Q24629891)

Handbook of experimental pharmacology

Europe PubMed Central

title

Mechanisms of acetaminophen-induced liver necrosis (English)

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1 reference

Jack A Hinson

1

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Dean W Roberts

series ordinal

2

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Laura P James

series ordinal

3

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language of work or name

English

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publication date

2010

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published in

1 reference

Nuclear dynamics of PCNA in DNA replication and repair

issue

196

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page(s)

369-405

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cites work

1 reference

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Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel

7 April 2017

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TNF-alpha regulates transforming growth factor-alpha expression in regenerating murine liver and isolated hepatocytes

7 April 2017

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Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

7 April 2017

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Novel CXCR2-dependent liver regenerative qualities of ELR-containing CXC chemokines

7 April 2017

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Acetaminophen-induced hepatotoxicity is associated with early changes in NF-kappa B and NF-IL6 DNA binding activity

7 April 2017

1 reference

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Regulation of the mitochondrial apoptosis-induced channel, MAC, by BCL-2 family proteins

7 April 2017

1 reference

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Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

7 April 2017

1 reference

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The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore

7 April 2017

1 reference

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Acetaminophen-induced hepatotoxicity

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Absence of endogenous interleukin 10 enhances early stress response during post-ischaemic injury in mice intestine

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

The hepatic inflammatory response after acetaminophen overdose: role of neutrophils

7 April 2017

1 reference

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Hypoxic stimulation of vascular endothelial growth factor expression in activated rat hepatic stellate cells

7 April 2017

1 reference

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N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen

7 April 2017

1 reference

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Acetaminophen-induced cytotoxicity in cultured mouse hepatocytes: correlation of nuclear Ca2+ accumulation and early DNA fragmentation with cell death

7 April 2017

1 reference

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Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

7 April 2017

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7 April 2017

1 reference

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Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Pathogenic role of natural killer T and natural killer cells in acetaminophen-induced liver injury in mice is dependent on the presence of dimethyl sulfoxide

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Protective role of c-Jun N-terminal kinase 2 in acetaminophen-induced liver injury

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

A tale of two mitochondrial channels, MAC and PTP, in apoptosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Mitochondrial abnormalities--a link to idiosyncratic drug hepatotoxicity?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

The 2006 Bernard B. Brodie Award Lecture. Cyp2e1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Leflunomide or A77 1726 protect from acetaminophen-induced cell injury through inhibition of JNK-mediated mitochondrial permeability transition in immortalized human hepatocytes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Role of neutrophils in acute inflammatory liver injury

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

CYP2E1--biochemical and toxicological aspects and role in alcohol-induced liver injury.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

TNF receptor superfamily-induced cell death: redox-dependent execution

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Is MAC the knife that cuts cytochrome c from mitochondria during apoptosis?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Sinusoidal endothelial cells as an early target for hepatic toxicants.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Apoptosis and necrosis in the liver: a tale of two deaths?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Mitochondrial nitric oxide synthase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Acetaminophen-induced hepatotoxicity: role of metabolic activation, reactive oxygen/nitrogen species, and mitochondrial permeability transition

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Mitogenic properties of endogenous and pharmacological doses of macrophage inflammatory protein-2 after 70% hepatectomy in the mouse

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Tumor necrosis factor alpha-induced interleukin-8 production via NF-kappaB and phosphatidylinositol 3-kinase/Akt pathways inhibits cell apoptosis in human hepatocytes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Mitochondrial ROS metabolism: modulation by uncoupling proteins.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Cytokine-responsive gene-2/IFN-inducible protein-10 expression in multiple models of liver and bile duct injury suggests a role in tissue regeneration

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Role of vascular endothelial growth factor in regulation of physiological angiogenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Mitochondrial permeability transition and oxidative stress

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Involvement of human cytochrome P450 2D6 in the bioactivation of acetaminophen

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S-transferase Pi.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Peroxynitrite scavenging by metalloporphyrins and thiolates

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Therapeutic use of chemokines

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Exaggerated hepatic injury due to acetaminophen challenge in mice lacking C-C chemokine receptor 2

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Selective protein arylation and acetaminophen-induced hepatotoxicity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Calcium-dependent DNA damage and adenosine 3',5'-cyclic monophosphate-independent glycogen phosphorylase activation in an in vitro model of acetaminophen-induced liver injury.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Liver cytoprotection by prostaglandins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Acetaminophen overdose. 662 cases with evaluation of oral acetylcysteine treatment

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

The Treatment of Acetaminophen Poisoning

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Liver necrosis from paracetamol

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Role of metals in oxygen radical reactions

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Immunohistochemical localization and quantification of the 3-(cystein-S-yl)-acetaminophen protein adduct in acetaminophen hepatotoxicity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Oxidative and reductive metabolism by cytochrome P450 2E1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Role of reactive oxygen species in cell toxicity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Selective protein covalent binding and target organ toxicity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Early sustained rise in total liver calcium during acetaminophen hepatotoxicity in mice.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Role of p55 tumor necrosis factor receptor 1 in acetaminophen-induced antioxidant defense

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Early expression of myocardial HIF-1alpha in response to mechanical stresses: regulation by stretch-activated channels and the phosphatidylinositol 3-kinase signaling pathway

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Effect of N-acetylcysteine on heat shock protein induction by acetaminophen in mouse liver.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Nitrotyrosine-protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in mice

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Induction of the mitochondrial permeability transition by peroxynitrite

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Sinusoidal endothelial cells as a target for acetaminophen toxicity. Direct action versus requirement for hepatocyte activation in different mouse strains.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Role of iron and glutathione redox cycle in acetaminophen-induced cytotoxicity to cultured rat hepatocytes

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Further characterization of the events involved in mitochondrial Ca2+ release and pore formation by prooxidants

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Paracetamol-stimulated lipid peroxidation in isolated rat and mouse hepatocytes

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Scanning electron microscopic examination of acetaminophen-induced hepatotoxicity and congestion in mice

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Hepatic damage from overdose of paracetamol

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Species differences in hepatic glutathione depletion, covalent binding and hepatic necrosis after acetaminophen.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Reversal of acetaminophen toxicity in isolated hamster hepatocytes by dithiothreitol

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Ferrous ion supported in vivo lipid peroxidation induced by paracetamol--its relation to hepatotoxicity.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

A sensitive immunochemical assay for acetaminophen-protein adducts.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

The spontaneous and enzymatic reaction of N-acetyl-p-benzoquinonimine with glutathione: A stopped-flow kinetic study

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Superoxide dismutase and catalase protect cultured hepatocytes from the cytotoxicity of acetaminophen.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Immunoblot analysis of protein containing 3-(cystein-S-yl)acetaminophen adducts in serum and subcellular liver fractions from acetaminophen-treated mice

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Rat liver endothelial and Kupffer cell-mediated mutagenicity of polycyclic aromatic hydrocarbons and aflatoxin B1

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Acetaminophen toxicity results in site-specific mitochondrial damage in isolated mouse hepatocytes.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Acetaminophen overdose: incidence, diagnosis, and management in 416 patients

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Acute liver necrosis following overdose of paracetamol

30 May 2018

1 reference

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Reversal of experimental paracetamol toxicosis with N-acetylcysteine

19 June 2018

1 reference

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Mitochondrial bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicity

19 June 2018

1 reference

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c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity

28 November 2018

1 reference

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Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity.

28 November 2018

1 reference

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Neutrophil depletion protects against murine acetaminophen hepatotoxicity

28 November 2018

1 reference

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Measurement of serum acetaminophen-protein adducts in patients with acute liver failure

28 November 2018

1 reference

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Genomic identification of potential risk factors during acetaminophen-induced liver disease in susceptible and resistant strains of mice

28 November 2018

1 reference

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Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity

28 November 2018

1 reference

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Generation of hypochlorite-modified proteins by neutrophils during ischemia-reperfusion injury in rat liver: attenuation by ischemic preconditioning

28 November 2018

1 reference

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Tumour necrosis factor receptor 1 and hepatocyte regeneration in acetaminophen toxicity: a kinetic study of proliferating cell nuclear antigen and cytokine expression

28 November 2018

1 reference

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Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity

28 November 2018

1 reference

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The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity

28 November 2018

1 reference

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Mechanisms of acetaminophen-induced hepatotoxicity: role of oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes

28 November 2018

1 reference

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NADPH oxidase-derived oxidant stress is critical for neutrophil cytotoxicity during endotoxemia

28 November 2018

1 reference

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Acetaminophen toxicity in mice lacking NADPH oxidase activity: role of peroxynitrite formation and mitochondrial oxidant stress

28 November 2018

1 reference

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A protective role of interleukin 11 on hepatic injury in acute endotoxemia

28 November 2018

1 reference

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Role of tumor necrosis factor receptor 1 (p55) in hepatocyte proliferation during acetaminophen-induced toxicity in mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Early hepatic microvascular injury in response to acetaminophen toxicity

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Exaggerated hepatotoxicity of acetaminophen in mice lacking tumor necrosis factor receptor-1 Potential role of inflammatory mediators

28 November 2018

1 reference

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Interleukin 6 and hepatocyte regeneration in acetaminophen toxicity in the mouse

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Calpain released from dying hepatocytes mediates progression of acute liver injury induced by model hepatotoxicants

28 November 2018

1 reference

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Role of nitric oxide in hepatic microvascular injury elicited by acetaminophen in mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Scavenging peroxynitrite with glutathione promotes regeneration and enhances survival during acetaminophen-induced liver injury in mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Involvement of mitochondria in acetaminophen-induced apoptosis and hepatic injury: roles of cytochrome c, Bax, Bid, and caspases

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Effect of N-acetylcysteine on acetaminophen toxicity in mice: relationship to reactive nitrogen and cytokine formation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Evaluation of the probes 2′,7′-dichlorofluorescin diacetate, luminol, and lucigenin as indicators of reactive species formation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Role of interleukin-6 in hepatic heat shock protein expression and protection against acetaminophen-induced liver disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Angiogenesis-independent endothelial protection of liver: role of VEGFR-1.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Reduced hepatotoxicity of acetaminophen in mice lacking inducible nitric oxide synthase: potential role of tumor necrosis factor-alpha and interleukin-10.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

2001 Annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

A pivotal involvement of IFN-gamma in the pathogenesis of acetaminophen-induced acute liver injury.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Mode of cell death after acetaminophen overdose in mice: apoptosis or oncotic necrosis?

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

The value of plasma acetaminophen half-life in antidote-treated acetaminophen overdosage

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Determination of acetaminophen-protein adducts in mouse liver and serum and human serum after hepatotoxic doses of acetaminophen using high-performance liquid chromatography with electrochemical detection

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Effect of inhibitors of nitric oxide synthase on acetaminophen-induced hepatotoxicity in mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Protection against acetaminophen-induced liver injury and lethality by interleukin 10: role of inducible nitric oxide synthase

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

A protective role for cyclooxygenase-2 in drug-induced liver injury in mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

IFN-gamma-inducible protein-10 (CXCL10) is hepatoprotective during acute liver injury through the induction of CXCR2 on hepatocytes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Enhanced acetaminophen hepatotoxicity in transgenic mice overexpressing BCL-2.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Acetaminophen-induced hepatotoxicity in mice lacking inducible nitric oxide synthase activity

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Elevation of serum interleukin 8 levels in acetaminophen overdose in children and adolescents

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Protective effect of rhIL-11 in a murine model of acetaminophen-induced hepatotoxicity

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Macrophage inflammatory protein-2 gene therapy attenuates adenovirus- and acetaminophen-mediated hepatic injury

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Acetaminophen hepatotoxicity in tumor necrosis factor/lymphotoxin-α gene knockout mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Intracellular calcium disruption as a secondary event in acetaminophen-induced hepatotoxicity.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Modulation of macrophage functioning abrogates the acute hepatotoxicity of acetaminophen.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Paracetamol overdose and liver damage

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

On the role of Ca2+ in the toxicity of alkylating and oxidizing quinone imines in isolated hepatocytes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

N-acetyl-p-benzoquinone imine-induced changes in the energy metabolism in hepatocytes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836803

Inhibition of tumour necrosis factor alpha does not prevent experimental paracetamol-induced hepatic necrosis

28 November 2018

1 reference

12 December 2020

Hepatoprotective role of interleukin 10 in galactosamine/lipopolysaccharide mouse liver injury

1 reference

12 December 2020

Mitochondrial permeability transition in hepatocytes induced by t-BuOOH: NAD(P)H and reactive oxygen species

1 reference

12 December 2020

Production and role of interleukin-10 in concanavalin A-induced hepatitis in mice

1 reference

12 December 2020

Glutathione Peroxidase Protects against Peroxynitrite-mediated Oxidations

1 reference

12 December 2020

Acetaminophen-induced hepatotoxic congestion in mice

1 reference

12 December 2020

Freshly isolated hepatocytes as a model for studying the toxicity of paracetamol

1 reference

12 December 2020

Potential role of activated macrophages in acetaminophen hepatotoxicity. I. Isolation and characterization of activated macrophages from rat liver

1 reference

12 December 2020

Potential role of activated macrophages in acetaminophen hepatotoxicity. II. Mechanism of macrophage accumulation and activation

1 reference

12 December 2020

Mechanisms of acetaminophen oxidation to N-acetyl-P-benzoquinone imine by horseradish peroxidase and cytochrome P-450

1 reference

12 December 2020

Immunochemical detection of acetaminophen-bound liver proteins

1 reference

12 December 2020

Global changes in interleukin-6–dependent gene expression patterns in mouse livers after partial hepatectomy

1 reference

12 December 2020

Selective acetaminophen metabolite binding to hepatic and extrahepatic proteins: an in vivo and in vitro analysis

1 reference

12 December 2020

Evidence in vivo for elevation of intracellular free Ca2+ in the liver after diquat, acetaminophen, and CCl4

1 reference

12 December 2020

Mechanism of paracetamol toxicity

1 reference

12 December 2020

Early loss of large genomic DNA in vivo with accumulation of Ca2+ in the nucleus during acetaminophen-induced liver injury

1 reference

12 December 2020

N-acetyl-p-benzoquinone imine induces Ca2+ release from mitochondria by stimulating pyridine nucleotide hydrolysis

1 reference

12 December 2020

Acetaminophen-induced cytotoxicity in cultured mouse hepatocytes: effects of Ca(2+)-endonuclease, DNA repair, and glutathione depletion inhibitors on DNA fragmentation and cell death

1 reference

12 December 2020

Tumor necrosis factor (TNF) up-regulates the expression of p75 but not p55 TNF receptors, and both receptors mediate, independently of each other, up-regulation of transforming growth factor alpha and epidermal growth factor receptor mRNA

1 reference

12 December 2020

Ca2+ antagonists inhibit DNA fragmentation and toxic cell death induced by acetaminophen

1 reference

12 December 2020

Enhancement of human hepatocyte growth factor production by interleukin-1 alpha and -1 beta and tumor necrosis factor-alpha by fibroblasts in culture

1 reference

12 December 2020

Formation of reactive cyclopentenone compounds in vivo as products of the isoprostane pathway

1 reference

12 December 2020

Deferoxamine delays the development of the hepatotoxicity of acetaminophen in mice

1 reference

12 December 2020

Plasma-paracetamol half-life and hepatic necrosis in patients with paracetamol overdosage

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12 December 2020

Experimental paracetamol-induced hepatic necrosis: A histopathological study

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12 December 2020

Acetaminophen-Induced Hepatic Necrosis and Renal Failure

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12 December 2020

Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism

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12 December 2020

Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro

1 reference

12 December 2020

Treating acute acetaminophen poisoning with acetylcysteine

1 reference

12 December 2020

Comparison of interleukin-11 and epidermal growth factor on residual small intestine after massive small bowel resection

1 reference

12 December 2020

Role of nitric oxide in acetaminophen-induced hepatotoxicity in the rat

1 reference

12 December 2020

Dichlorodihydrofluorescein and dihydrorhodamine 123 are sensitive indicators of peroxynitrite in vitro: implications for intracellular measurement of reactive nitrogen and oxygen species

1 reference

12 December 2020

The mitochondrial permeability transition: from biochemical curiosity to pathophysiological mechanism

1 reference

12 December 2020

Molecular mechanism and role of endothelial monocyte chemoattractant protein-1 induction by vascular endothelial growth factor

1 reference

12 December 2020

Vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity

1 reference

12 December 2020

Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury

1 reference

12 December 2020

Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injury

1 reference

12 December 2020

Hepatoprotective role of endogenous interleukin-13 in a murine model of acetaminophen-induced liver disease

1 reference

12 December 2020

Role of apoptosis in acetaminophen hepatotoxicity

1 reference

12 December 2020

VEGF isoforms and receptors expression throughout acute acetaminophen-induced liver injury and regeneration

1 reference

12 December 2020

Paracetamol metabolism and toxicity in isolated hepatocytes from rat and mouse

1 reference

12 December 2020

Acute paracetamol intoxication of starved mice leads to lipid peroxidation in vivo

1 reference

12 December 2020

Acetaminophen-induced hepatotoxicity in mice

1 reference

12 December 2020

Formation of chemically reactive metabolites of phenacetin and acetaminophen

1 reference

12 December 2020

3-(glutathion-S-yl)acetaminophen: a biliary metabolite of acetaminophen

1 reference

12 December 2020

Synthesis, decomposition kinetics, and preliminary toxicological studies of pure N-acetyl-p-benzoquinone imine, a proposed toxic metabolite of acetaminophen

1 reference

12 December 2020

Effects of N-acetylcysteine on the disposition and metabolism of acetaminophen in mice

1 reference

12 December 2020

A comparative study of drug-metabolizing enzymes present in isolated rat liver parenchymal, Kupffer and endothelial cells

1 reference

12 December 2020

Immunochemical quantitation of 3-(cystein-S-yl)acetaminophen adducts in serum and liver proteins of acetaminophen-treated mice

1 reference

12 December 2020

Subcellular binding and effects on calcium homeostasis produced by acetaminophen and a nonhepatotoxic regioisomer, 3'-hydroxyacetanilide, in mouse liver

1 reference

12 December 2020

Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2

1 reference

12 December 2020

Oxidation of acetaminophen to N-acetyl-p-aminobenzoquinone imine by human CYP3A4

1 reference

12 December 2020

Oxidative stress in cultured hepatocytes exposed to acetaminophen

1 reference

12 December 2020

Inhibition of mitochondrial respiration in vivo is an early event in acetaminophen-induced hepatotoxicity

1 reference

12 December 2020

Loss of CYP2E1 and CYP1A2 activity as a function of acetaminophen dose: relation to toxicity

1 reference

12 December 2020

Effects of N-acetylcysteine and dithiothreitol on glutathione and protein thiol replenishment during acetaminophen-induced toxicity in isolated mouse hepatocytes

1 reference

12 December 2020

Protection against acetaminophen-induced liver injury in vivo by an iron chelator, deferoxamine

1 reference

12 December 2020

Role of Proinflammatory Cytokines in Acetaminophen Hepatotoxicity

1 reference

12 December 2020

The human and economic cost of paracetamol (acetaminophen) overdose

1 reference

12 December 2020

Acetaminophen-induced microvascular injury in the rat liver: protection with misoprostol

1 reference

12 December 2020

Protection in the late stages of paracetamol-induced liver cell injury with fructose, cyslosporin A and trifluoperazine

1 reference

12 December 2020

Acetaminophen-arylated proteins are detected in hepatic subcellular fractions and numerous extra-hepatic tissues in CD-1 and C57B1/6J mice

1 reference

12 December 2020

Histopathology of acetaminophen-induced liver changes: role of interleukin 1 alpha and tumor necrosis factor alpha

1 reference

12 December 2020

Mechanism of acetaminophen-induced hepatotoxicity: covalent binding versus oxidative stress

1 reference

12 December 2020

Effect of nifedipine, verapamil, diltiazem and trifluoperazine on acetaminophen toxicity in mice

1 reference

12 December 2020

Increased expressions of vascular endothelial growth factor and its receptors, flt-1 and KDR/flk-1, in regenerating rat liver

1 reference

12 December 2020

Effect of acetaminophen administration on hepatic glutathione compartmentation and mitochondrial energy metabolism in the rat

1 reference

12 December 2020

Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment

1 reference

12 December 2020

Malignancy in relatives of patients with adult coeliac disease

1 reference

Crossref

https://api.crossref.org/works/10.1007%2F978-3-642-00663-0_12

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1007/978-3-642-00663-0_12

1 reference

1 reference

1 reference

PubMed publication ID

20020268

1 reference