Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism (Q24611305)

12

Michael P Lisanti

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Diana Whitaker-Menezes

3

Diana Whitaker-Menezes

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Richard Pestell

5

Richard G Pestell

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Philippe G. Frank

7

Ubaldo E Martinez-Outschoorn

Philippe G Frank

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10

Ubaldo E Martinez-Outschoorn

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Barbara Chiavarina

6

Barbara Chiavarina

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Neal Flomenberg

8

Neal Flomenberg

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Stephanos Pavlides

4

Stephanos Pavlides

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Gloria Bonuccelli

1

Gloria Bonuccelli

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Anthony Howell

9

Anthony Howell

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Aristotelis Tsirigos

2

The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism

Aristotelis Tsirigos

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language of work or name

English

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publication date

1 September 2010

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published in

Cell Cycle

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volume

9

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issue

17

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page(s)

3506-14

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cites work

1 reference

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Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells

7 April 2017

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Transcriptional evidence for the "Reverse Warburg Effect" in human breast cancer tumor stroma and metastasis: similarities with oxidative stress, inflammation, Alzheimer's disease, and "Neuron-Glia Metabolic Coupling"

7 April 2017

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Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancers

7 April 2017

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Stromal cell expression of caveolin-1 predicts outcome in breast cancer

7 April 2017

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An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers

7 April 2017

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Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

7 April 2017

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Stromal caveolin-1 levels predict early DCIS progression to invasive breast cancer

7 April 2017

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Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor

7 April 2017

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Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: implications for breast cancer and DCIS therapy with autophagy inhibitors

22 April 2017

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The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts

27 September 2017

1 reference

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Epidemiological aspects of neoplasms in diabetes

27 September 2017

1 reference

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The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

27 September 2017

1 reference

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An absence of stromal caveolin-1 is associated with advanced prostate cancer, metastatic disease and epithelial Akt activation

27 September 2017

1 reference

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Neuroprotection in diet-induced ketotic rat brain after focal ischemia

27 September 2017

1 reference

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Molecular signatures suggest a major role for stromal cells in development of invasive breast cancer

27 September 2017

1 reference

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Severe lactic acidosis in a 14-year-old female with metastatic undifferentiated carcinoma of unknown primary

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047616

The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism

27 September 2017

1 reference

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Ketoacids? Good medicine?

27 September 2017

1 reference

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Ketone bodies, potential therapeutic uses

27 September 2017

1 reference

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Lactic acidosis and small cell carcinoma of the lung

27 September 2017

1 reference

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Common emergencies in cancer medicine: metabolic syndromes.

27 September 2017

1 reference

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Lactic acidosis. A presentation of metastatic breast cancer arising in pregnancy.

27 September 2017

1 reference

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Type B lactic acidosis and metastatic breast cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047616

Disseminated intravascular coagulation: experience in a major cancer center

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047616

Inhibition of lactate transport and glycolysis in Ehrlich ascites tumor cells by bioflavonoids

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047616

Serum lactate dehydrogenase level in various malignancies

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047616

Suppression of transforming growth factor beta/smad signaling in keloid-derived fibroblasts by quercetin: implications for the treatment of excessive scars.

27 September 2017

1 reference

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The effect of an acute fast on human head and neck carcinoma xenograft. Growth effects on an 'isolated tumor vascular pedicle' in the nude rat.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047616

Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect": a transcriptional informatics analysis with validation

30 May 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.9.17.12731

dl-3-Hydroxybutyrate administration prevents myocardial damage after coronary occlusion in rat hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.9.17.12731

Predictors of central nervous system metastasis in patients with metastatic breast cancer. A competing risk analysis of 579 patients treated with epirubicin-based chemotherapy

21 January 2018

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https://api.crossref.org/works/10.4161%2FCC.9.17.12731

Prognostic factors and long-term survival in 585 patients with metastatic breast cancer treated with epirubicin-based chemotherapy

21 January 2018

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https://api.crossref.org/works/10.4161%2FCC.9.17.12731

Cancer presenting as fatal pulmonary tumour embolism

21 January 2018

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https://api.crossref.org/works/10.4161%2FCC.9.17.12731

Aggressive undifferentiated carcinoma of unknown primary site complicated by lactic acidosis after bleeding: a case report

21 January 2018

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https://api.crossref.org/works/10.4161%2FCC.9.17.12731

The role of malignancy in lactic acidosis and shock.

21 January 2018

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https://api.crossref.org/works/10.4161%2FCC.9.17.12731

In vitro anti-fibrotic activities of herbal compounds and herbs.

21 January 2018

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https://api.crossref.org/works/10.4161%2FCC.9.17.12731

Prognostic factors for survival in metastatic breast cancer during first-line paclitaxel chemotherapy

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047616

Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047616

Metastatic reticulum cell sarcoma and lactic acidosis

28 November 2018

1 reference

12 December 2020

Lactic acidosis associated with metastatic breast carcinoma

1 reference

12 December 2020

Lactic acidosis in oat cell carcinoma with extensive hepatic metastases

1 reference

12 December 2020

Lactic acidosis associated with metastatic osteogenic sarcoma

1 reference

12 December 2020

Lactic acidosis in lung cancer

1 reference

12 December 2020

Lactic acidosis: a metabolic complication of extensive metastatic cancer

1 reference

12 December 2020

Biochemical and hematological tests in patients with breast carcinoma: correlations with extent of disease, sites of relapse, and prognosis

1 reference

12 December 2020

Serum glycolytic enzymes in breast carcinoma

1 reference

12 December 2020

Stimulation of tumor growth in adult rats in vivo during acute streptozotocin-induced diabetes

1 reference

12 December 2020

Diagnostic and prognostic significance of serum cholinesterase and lactate dehydrogenase in breast cancer

1 reference

12 December 2020

Significance of serum ferritin and lactate dehydrogenase in benign and malignant disease of breast

1 reference

12 December 2020

Fatal lactic acidosis due to widespread diffusion of melanoma

1 reference

12 December 2020

Serum and tissue LDH levels in patients with breast/gynaecological cancer and benign diseases

1 reference

12 December 2020

Acute fulminant lactic acidosis complicating metastatic cholangiocarcinoma

1 reference

12 December 2020

Clinical survival predictors in patients with advanced cancer

1 reference

12 December 2020

Identifiers

DOI

10.4161/CC.9.17.12731

1 reference

1 reference

1 reference

PubMed publication ID

20818174

1 reference