PTEN as an effector in the signaling of antimigratory G protein-coupled receptor (Q24555751)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15764699%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

title

PTEN as an effector in the signaling of antimigratory G protein-coupled receptor (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15764699%20AND%20SRC:MED&resulttype=core&format=json

G protein-coupled receptor

9 January 2020

main subject

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author

Christopher D. Kontos

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15764699%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Timothy Hla

7

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9 January 2020

author name string

Teresa Sanchez

1

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9 January 2020

Shobha Thangada

2

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9 January 2020

Ming-Tao Wu

3

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9 January 2020

Dianqing Wu

5

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9 January 2020

Hong Wu

6

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9 January 2020

language of work or name

English

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publication date

11 March 2005

1 reference

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Proceedings of the National Academy of Sciences of the United States of America

9 January 2020

published in

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9 January 2020

volume

102

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9 January 2020

issue

12

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9 January 2020

page(s)

4312-4317

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Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

9 January 2020

cites work

1 reference

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Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2

24 March 2017

1 reference

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Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate

24 March 2017

1 reference

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The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region

24 March 2017

1 reference

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Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis

24 March 2017

1 reference

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Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

24 March 2017

1 reference

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

24 March 2017

1 reference

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Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1

24 March 2017

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Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activation

24 March 2017

1 reference

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The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway

24 March 2017

1 reference

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Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association

24 March 2017

1 reference

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

24 March 2017

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High-efficiency transformation of mammalian cells by plasmid DNA

24 March 2017

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The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

24 March 2017

1 reference

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The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

24 March 2017

1 reference

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Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB

24 March 2017

1 reference

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Lysophospholipids--receptor revelations

24 March 2017

1 reference

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Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins

24 March 2017

1 reference

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Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555509

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

24 March 2017

1 reference

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

24 March 2017

1 reference

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Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555509

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555509

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

24 March 2017

1 reference

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An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors

24 March 2017

1 reference

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Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists

24 March 2017

1 reference

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Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

7 April 2017

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Prostaglandin E(2) inhibits fibroblast migration by E-prostanoid 2 receptor-mediated increase in PTEN activity

7 April 2017

1 reference

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Physiological and pathological actions of sphingosine 1-phosphate.

27 September 2017

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Point-counterpoint of sphingosine 1-phosphate metabolism

27 September 2017

1 reference

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Regulation of cell migration by the C2 domain of the tumor suppressor PTEN.

27 September 2017

1 reference

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Membrane-binding and activation mechanism of PTEN.

27 September 2017

1 reference

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Inhibitory and stimulatory regulation of Rac and cell motility by the G12/13-Rho and Gi pathways integrated downstream of a single G protein-coupled sphingosine-1-phosphate receptor isoform

27 September 2017

1 reference

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Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3.

27 September 2017

1 reference

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The immune modulator FTY720 targets sphingosine 1-phosphate receptors

27 September 2017

1 reference

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Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555509

Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555509

Akt down-regulation of p38 signaling provides a novel mechanism of vascular endothelial growth factor-mediated cytoprotection in endothelial cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555509

Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of alpha vbeta3- and beta1-containing integrins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555509

Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555509

Ephrins and their Eph receptors: multitalented directors of embryonic development

27 September 2017

1 reference

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Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555509

The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555509

Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils

28 November 2018

1 reference

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Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555509

Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555509

Tumor suppressor PTEN mediates sensing of chemoattractant gradients.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555509

Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555509

Sphingosine-1-phosphate, a platelet-derived lysophospholipid mediator, negatively regulates cellular Rac activity and cell migration in vascular smooth muscle cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555509

Modulation of intracellular beta-catenin localization and intestinal tumorigenesis in vivo and in vitro by sphingolipids

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555509

PTEN modulates vascular endothelial growth factor-mediated signaling and angiogenic effects

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15764699

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12 December 2020

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Identifiers

DOI

10.1073/PNAS.0409784102

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15764699%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

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mapped directly with Wikidata item

24 November 2022

based on heuristic

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2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15764699%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

PubMed publication ID

15764699

2 references