Elongation of the Kcnq1ot1 transcript is required for genomic imprinting of neighboring genes (Q24546155)

1

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Scott J S Steele

2

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John M Levorse

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Robert S Ingram

An antisense RNA regulates the bidirectional silencing property of the Kcnq1 imprinting control region

4

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language of work or name

English

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publication date

15 May 2006

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published in

Genes & Development

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volume

20

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issue

10

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page(s)

1268-82

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cites work

1 reference

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Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice

24 March 2017

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Analysis of germline CDKN1C (p57KIP2) mutations in familial and sporadic Beckwith-Wiedemann syndrome (BWS) provides a novel genotype-phenotype correlation

24 March 2017

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A maternally methylated CpG island in KvLQT1 is associated with an antisense paternal transcript and loss of imprinting in Beckwith-Wiedemann syndrome

24 March 2017

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X-inactivation profile reveals extensive variability in X-linked gene expression in females

24 March 2017

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RNAi-mediated pathways in the nucleus

24 March 2017

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Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting

24 March 2017

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Killing the messenger: short RNAs that silence gene expression

24 March 2017

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Genome imprinting regulated by the mouse Polycomb group protein Eed

24 March 2017

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The non-coding Air RNA is required for silencing autosomal imprinted genes

24 March 2017

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CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus

24 March 2017

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Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene

24 March 2017

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An imprinted gene p57KIP2 is mutated in Beckwith-Wiedemann syndrome

24 March 2017

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Disruption of imprinting caused by deletion of the H19 gene region in mice

24 March 2017

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CTCF maintains differential methylation at the Igf2/H19 locus

24 March 2017

1 reference

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Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1

24 March 2017

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Rb targets histone H3 methylation and HP1 to promoters

24 March 2017

1 reference

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Role for DNA methylation in genomic imprinting

7 April 2017

1 reference

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The human XIST gene: analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus

7 April 2017

1 reference

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Evolution of the Beckwith-Wiedemann syndrome region in vertebrates

7 April 2017

1 reference

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Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes.

27 September 2017

1 reference

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The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472902

Hierarchical recruitment of polycomb group silencing complexes

27 September 2017

1 reference

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Antisense regulation in X inactivation and autosomal imprinting

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472902

Domain regulation of imprinting cluster in Kip2/Lit1 subdomain on mouse chromosome 7F4/F5: large-scale DNA methylation analysis reveals that DMR-Lit1 is a putative imprinting control region

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472902

Shared role for differentially methylated domains of imprinted genes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472902

Chromosomal silencing and localization are mediated by different domains of Xist RNA.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472902

Regulation of DNA methylation of Rasgrf1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472902

Sequence and functional comparison in the Beckwith-Wiedemann region: implications for a novel imprinting centre and extended imprinting

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472902

A transcriptional insulator at the imprinted H19/Igf2 locus

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472902

De novo deletions of SNRPN exon 1 in early human and mouse embryos result in a paternal to maternal imprint switch

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472902

Beckwith-Wiedemann syndrome: imprinting in clusters revisited

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472902

Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472902

Multiple mechanisms regulate imprinting of the mouse distal chromosome 7 gene cluster

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472902

CpG methylation within the 5′ regulatory region of the BRCA1 gene is tumor specific and includes a putative CREB binding site

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472902

Coding mutations in p57KIP2 are present in some cases of Beckwith-Wiedemann syndrome but are rare or absent in Wilms tumors

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472902

Genomic imprinting of Mash2, a mouse gene required for trophoblast development

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472902

Genomic imprinting of p57KIP2, a cyclin-dependent kinase inhibitor, in mouse

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472902

Development of reconstituted mouse eggs suggests imprinting of the genome during gametogenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472902

Mtr1, a novel biallelically expressed gene in the center of the mouse distal chromosome 7 imprinting cluster, is a member of the Trp gene family

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472902

Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472902

Evolutionary conservation of possible functional domains of the human and murine XIST genes

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472902

Methylation at mouse Cdkn1c is acquired during postimplantation development and functions to maintain imprinted expression.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472902

Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472902

Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472902

A differentially methylated region within the gene Kcnq1 functions as an imprinted promoter and silencer

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472902

Dnmt3L and the establishment of maternal genomic imprints

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472902

The H19 methylation imprint is erased and re-established differentially on the parental alleles during male germ cell development

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472902

Parental origin-specific expression of Mash2 is established at the time of implantation with its imprinting mechanism highly resistant to genome-wide demethylation.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472902

Imprinting of mouse Kvlqt1 is developmentally regulated.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472902

Imprinted expression of the Igf2r gene depends on an intronic CpG island.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472902

Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith–Wiedemann syndrome

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472902

Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472902

A paternal-specific methylation imprint marks the alleles of the mouse H19 gene

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472902

Developmental pattern of gene-specific DNA methylation in the mouse embryo and germ line

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472902

Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive

28 November 2018

1 reference

12 December 2020

Bidirectional silencing and DNA methylation-sensitive methylation-spreading properties of the Kcnq1 imprinting control region map to the same regions

1 reference

12 December 2020

Inability of mouse blastomere nuclei transferred to enucleated zygotes to support development in vitro

1 reference

12 December 2020

Site and sequence specific DNA methylation in the neurofibromatosis (NF1) gene includes C5839T: the site of the recurrent substitution mutation in exon 31

1 reference

12 December 2020

Identifiers

DOI

10.1101/GAD.1416906

1 reference

1 reference

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PubMed publication ID

16702402

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