Rapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells (Q24538036)

21 June 2017

title

Rapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells (English)

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21 June 2017

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8

Harold L Moses

1 reference

21 June 2017

Brian K Law

1

1 reference

21 June 2017

Anna Chytil

2

1 reference

21 June 2017

Nancy Dumont

3

1 reference

21 June 2017

Elizabeth G Hamilton

4

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21 June 2017

Mary E Waltner-Law

5

1 reference

21 June 2017

Mary E Aakre

6

1 reference

21 June 2017

Cassondra Covington

7

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21 June 2017

language of work or name

English

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publication date

1 December 2002

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Molecular and Cellular Biology

21 June 2017

published in

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21 June 2017

volume

22

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21 June 2017

issue

23

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21 June 2017

page(s)

8184-8198

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Transforming growth factor β-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells

21 June 2017

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24 March 2017

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7 April 2017

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The E2F1-3 transcription factors are essential for cellular proliferation.

7 April 2017

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c-myc is a downstream target of the Smad pathway

27 September 2017

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Blocking oncogenic Ras signaling for cancer therapy

27 September 2017

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Association between the T29-->C polymorphism in the transforming growth factor beta1 gene and breast cancer among elderly white women: The Study of Osteoporotic Fractures.

27 September 2017

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TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

27 September 2017

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Antitumor activity of the rapamycin analog CCI-779 in human primitive neuroectodermal tumor/medulloblastoma models as single agent and in combination chemotherapy.

27 September 2017

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FKBP12, the 12-kDa FK506-binding protein, is a physiologic regulator of the cell cycle

27 September 2017

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Role of transforming growth factor beta in cancer

27 September 2017

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Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor beta growth arrest program

27 September 2017

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Disruption of TGF-beta growth inhibition by oncogenic ras is linked to p27Kip1 mislocalization

27 September 2017

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27 September 2017

c-Myc in breast cancer

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A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta -induced cell-cycle arrest

27 September 2017

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Mitogenic conversion of transforming growth factor-beta1 effect by oncogenic Ha-Ras-induced activation of the mitogen-activated protein kinase signaling pathway in human prostate cancer.

27 September 2017

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NF-kappa B is required for H-ras oncogene induced abnormal cell proliferation and tumorigenesis

27 September 2017

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27 September 2017

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Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A.

27 September 2017

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Myc downregulation by transforming growth factor beta required for activation of the p15(Ink4b) G(1) arrest pathway.

27 September 2017

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MYC oncogenes and human neoplastic disease

27 September 2017

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Inhibition of DNA synthesis by a farnesyltransferase inhibitor involves inhibition of the p70(s6k) pathway

27 September 2017

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Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc.

27 September 2017

1 reference

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Studies on the mechanism of resistance to rapamycin in human cancer cells

27 September 2017

1 reference

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TGF-beta1 effects on proliferation of rat intestinal epithelial cells are due to inhibition of cyclin D1 expression

27 September 2017

1 reference

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Mechanism of TGFβ receptor inhibition by FKBP12

27 September 2017

1 reference

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Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F.

27 September 2017

1 reference

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E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor beta through E2F binding sites

27 September 2017

1 reference

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Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1

27 September 2017

1 reference

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Nuclear localization of p85s6k: functional requirement for entry into S phase.

27 September 2017

1 reference

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Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression

27 September 2017

1 reference

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Mammary tumor suppression by transforming growth factor beta 1 transgene expression

27 September 2017

1 reference

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Overexpression of the c-Myc oncoprotein blocks the growth-inhibitory response but is required for the mitogenic effects of transforming growth factor beta 1.

27 September 2017

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A link between increased transforming activity of lymphoma-derived MYC mutant alleles, their defective regulation by p107, and altered phosphorylation of the c-Myc transactivation domain

27 September 2017

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Efficient screening of retroviral cDNA expression libraries

27 September 2017

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TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin.

27 September 2017

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Transforming growth factors and control of neoplastic cell growth

27 September 2017

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Transforming growth factor beta regulation of cell proliferation

27 September 2017

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E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor

27 September 2017

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Factor-binding element in the human c-myc promoter involved in transcriptional regulation by transforming growth factor beta 1 and by the retinoblastoma gene product

27 September 2017

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Early gene responses to transforming growth factor-beta in cells lacking growth-suppressive RB function

27 September 2017

1 reference

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Three distinct elements within the murine c-myc promoter are required for transcription

27 September 2017

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Alterations of the retinoblastoma gene in human prostate adenocarcinoma

27 September 2017

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TGF beta in prostate cancer: a growth inhibitor that can enhance tumorigenicity

27 September 2017

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Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin

27 September 2017

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p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F.

27 September 2017

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Regulation of cell growth and cyclin D1 expression by the constitutively active FRAP-p70s6K pathway in human pancreatic cancer cells

27 September 2017

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Translational induction of the c-myc oncogene via activation of the FRAP/TOR signalling pathway

30 May 2018

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TGF-beta-signaling with small molecule FKBP12 antagonists that bind myristoylated FKBP12-TGF-beta type I receptor fusion proteins

30 May 2018

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Transforming growth factor-beta1 is a new form of tumor suppressor with true haploid insufficiency.

30 May 2018

1 reference

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Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability

30 May 2018

1 reference

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Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene.

30 May 2018

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TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains.

30 May 2018

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Tumorigenic transformation of NIH 3T3 cells by the autocrine synthesis of transforming growth factor alpha

30 May 2018

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The effect of H-ras oncogene transfection on response of mink lung epithelial cells to growth factors and cytotoxic drugs

30 May 2018

1 reference

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Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity

30 May 2018

1 reference

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mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer

29 November 2018

1 reference

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Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition

29 November 2018

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Stem cell factor/c-kit up-regulates cyclin D3 and promotes cell cycle progression via the phosphoinositide 3-kinase/p70 S6 kinase pathway in spermatogonia

29 November 2018

1 reference

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Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a Senescence-like Arrest Mediated by p27Kip1

29 November 2018

1 reference

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Transgenic mice overexpressing a dominant-negative mutant type II transforming growth factor beta receptor show enhanced tumorigenesis in the mammary gland and lung in response to the carcinogen 7,12-dimethylbenz-[a]-anthracene

29 November 2018

1 reference

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The immunophilin FKBP12 functions as a common inhibitor of the TGF beta family type I receptors.

29 November 2018

1 reference

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Cdk2 kinase is required for entry into mitosis as a positive regulator of Cdc2-cyclin B kinase activity

29 November 2018

1 reference

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Clustered mutations in the second exon of the MYC gene in sporadic Burkitt's lymphoma.

29 November 2018

1 reference

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Site-specific modulation of c-Myc cotransformation by residues phosphorylated in vivo.

29 November 2018

1 reference

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Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas

29 November 2018

1 reference

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Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway

29 November 2018

1 reference

12 December 2020

TbetaR-I(6A) is a candidate tumor susceptibility allele

1 reference

12 December 2020

c-Myc hot spot mutations in lymphomas result in inefficient ubiquitination and decreased proteasome-mediated turnover

1 reference

12 December 2020

Transforming growth factor beta 1 regulation of c-myc expression, pRB phosphorylation, and cell cycle progression in keratinocytes

1 reference

12 December 2020

Release from G1 growth arrest by transforming growth factor beta 1 requires cellular ras activity

1 reference

12 December 2020

ErbB2/neu kinase modulates cellular p27(Kip1) and cyclin D1 through multiple signaling pathways

1 reference

12 December 2020

An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct

1 reference

12 December 2020

Transforming growth factor-β receptors on human endometrial cells: identification of the type I, II, and III receptors and glycosylphosphatidylinositol anchored TGF-β binding proteins

1 reference

12 December 2020

Characterization of the Interaction of FKBP12 with the Transforming Growth Factor-β Type I Receptorin Vivo

1 reference

12 December 2020

A role for a p21-E2F interaction during senescence arrest of normal human fibroblasts

1 reference

12 December 2020

Growth factors and cancer

1 reference

12 December 2020

Insensitivity to growth inhibition by TGF-beta1 correlates with a lack of inhibition of the CDK2 activity in prostate carcinoma cells

1 reference

12 December 2020

10.1128/MCB.22.23.8184-8198.2002

Identifiers

DOI

1 reference

OpenCitations bibliographic resource ID

21 June 2017

4111092

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

4111092

1 reference