Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b (Q24337331)

4

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Titia Sixma

object named as

Titia K Sixma

6

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author name string

Gretel Buchwald

1

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Petra van der Stoop

2

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Maarten van Lohuizen

Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex

5

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language of work or name

English

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publication date

7 June 2006

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published in

The EMBO Journal

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volume

25

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issue

11

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page(s)

2465-74

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cites work

1 reference

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Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase

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E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP-ribosylation factor domain protein 1)

19 March 2017

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Role of histone H2A ubiquitination in Polycomb silencing

19 March 2017

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Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53

19 March 2017

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Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex

19 March 2017

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Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition

19 March 2017

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Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains

19 March 2017

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Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

19 March 2017

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The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

19 March 2017

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U box proteins as a new family of ubiquitin-protein ligases

19 March 2017

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RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

19 March 2017

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RING1 interacts with multiple Polycomb-group proteins and displays tumorigenic activity

19 March 2017

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Structural insights into the U-box, a domain associated with multi-ubiquitination

19 March 2017

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Structure of a BRCA1-BARD1 heterodimeric RING-RING complex

19 March 2017

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Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

19 March 2017

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Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster

27 September 2017

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Coot: model-building tools for molecular graphics

19 March 2017

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Methods used in the structure determination of bovine mitochondrial F1 ATPase

19 March 2017

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The CCP4 suite: programs for protein crystallography

19 March 2017

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Substructure solution with SHELXD

19 March 2017

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19 March 2017

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Mechanisms underlying ubiquitination

27 September 2017

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Automated protein model building combined with iterative structure refinement

19 March 2017

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Efficient anisotropic refinement of macromolecular structures using FFT

19 March 2017

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Protein structure comparison by alignment of distance matrices

19 March 2017

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Improved methods for building protein models in electron density maps and the location of errors in these models

19 March 2017

1 reference

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Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing

19 March 2017

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Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice

19 March 2017

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Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation

19 March 2017

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Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

19 March 2017

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BRCA1 RING domain cancer-predisposing mutations. Structural consequences and effects on protein-protein interactions

19 March 2017

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E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme

19 March 2017

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The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation

19 March 2017

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Themes and variations on ubiquitylation

19 March 2017

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Loss- and gain-of-function mutations show a polycomb group function for Ring1A in mice

19 March 2017

1 reference

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RING finger proteins: mediators of ubiquitin ligase activity

19 March 2017

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19 March 2017

RING for destruction?

1 reference

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Ring1A is a transcriptional repressor that interacts with the Polycomb-M33 protein and is expressed at rhombomere boundaries in the mouse hindbrain.

19 March 2017

1 reference

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Ubiquitin: structures, functions, mechanisms

19 March 2017

1 reference

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Epigenome programming by Polycomb and Trithorax proteins.

7 April 2017

1 reference

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Of mice, flies, and man: the emerging role of polycomb-group genes in human malignant lymphomas

27 September 2017

1 reference

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Polycomb complexes and silencing mechanisms.

27 September 2017

1 reference

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Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas

27 September 2017

1 reference

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Polycomb, epigenomes, and control of cell identity

27 September 2017

1 reference

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Polycomb repression: from cellular memory to cellular proliferation and cancer.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1478191

RING domains: master builders of molecular scaffolds?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1478191

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF.

27 September 2017

1 reference

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Substrate targeting in the ubiquitin system

27 September 2017

1 reference

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Towards rationalization of crystallization screening for small- to medium-sized academic laboratories: the PACT/JCSG+ strategy

27 September 2017

1 reference

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SUMO modification of the ubiquitin-conjugating enzyme E2-25K

29 November 2018

1 reference

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Structure and biochemical function of a prototypical Arabidopsis U-box domain

29 November 2018

1 reference

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Molecular and genetic analysis of the Polycomb group gene Sex combs extra/Ring in Drosophila

29 November 2018

1 reference

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Reconstitution of a functional core polycomb repressive complex.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1478191

29 November 2018

Epigenetics and cancer

1 reference

12 December 2020

Ring1b-mediated H2A ubiquitination associates with inactive X chromosomes and is involved in initiation of X inactivation

1 reference

12 December 2020

[27] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods.

1 reference

12 December 2020

Perturbation of B and T cell development and predisposition to lymphomagenesis in EμBmi1 transgenic mice require the Bmi1 RING finger

1 reference

12 December 2020

Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7601144

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/SJ.EMBOJ.7601144

1 reference

1 reference

1 reference

PubMed publication ID

16710298

1 reference