Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance (Q24329133)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18718909%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

title

Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance (English)

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12 January 2020

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Pyruvate dehydrogenase kinase 3

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hypoxia-inducible factor-1alpha signaling pathway

GOA release 2020-03-11

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GOA release 2020-03-11

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5

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12 January 2020

author name string

Chun-Wun Lu

1

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12 January 2020

Shih-Chieh Lin

2

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12 January 2020

Ko-Fan Chen

3

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12 January 2020

Yen-Yu Lai

4

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12 January 2020

language of work or name

English

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publication date

21 August 2008

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Journal of Biological Chemistry

12 January 2020

published in

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12 January 2020

volume

283

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12 January 2020

issue

42

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12 January 2020

page(s)

28106-28114

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Transcriptional repression of human cad gene by hypoxia inducible factor-1alpha

12 January 2020

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A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

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19 March 2017

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19 March 2017

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HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

19 March 2017

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19 March 2017

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Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases

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Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α

19 March 2017

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Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

19 March 2017

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Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer

7 April 2017

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Aberrant expression of leptin in human endometriotic stromal cells is induced by elevated levels of hypoxia inducible factor-1alpha

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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21 January 2018

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21 January 2018

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21 January 2018

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Targeted upregulation of pyruvate dehydrogenase kinase (PDK)-4 in slow-twitch skeletal muscle underlies the stable modification of the regulatory characteristics of PDK induced by high-fat feeding

29 November 2018

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12 December 2020

Starvation increases the amount of pyruvate dehydrogenase kinase in several mammalian tissues

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12 December 2020

Mechanism responsible for inactivation of skeletal muscle pyruvate dehydrogenase complex in starvation and diabetes

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12 December 2020

Hypoxia-Inducible Factor-1 (HIF-1)

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12 December 2020

Identifiers

DOI

10.1074/JBC.M803508200

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18718909%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18718909%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

PubMed publication ID

18718909

2 references