The pro-form of BMP-2 interferes with BMP-2 signalling by competing with BMP-2 for IA receptor binding (Q24321603)

8

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Matthias Zebisch

5

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author name string

Anja Hauburger

1

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Sabrina von Einem

2

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Gerburg K Schwaerzer

3

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Anja Buttstedt

4

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Michael Schräml

6

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Peter Hortschansky

7

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Elisabeth Schwarz

The structural basis of TGF-beta, bone morphogenetic protein, and activin ligand binding

9

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language of work or name

English

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publication date

November 2009

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published in

FEBS Journal

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volume

276

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issue

21

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page(s)

6386-98

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cites work

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Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors

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The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways.

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Signal transduction of bone morphogenetic protein receptors

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Biophysical comparison of BMP-2, ProBMP-2, and the free pro-peptide reveals stabilization of the pro-peptide by the mature growth factor.

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Dissecting the diverse actions of pro- and mature neurotrophins

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Jekyll-Hyde neurotrophins: the story of proNGF

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Sortilin is essential for proNGF-induced neuronal cell death

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A common biosynthetic pathway governs the dimerization and secretion of inhibin and related transforming growth factor beta (TGFbeta) ligands

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GDF-8 propeptide binds to GDF-8 and antagonizes biological activity by inhibiting GDF-8 receptor binding

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Characterization and identification of the inhibitory domain of GDF-8 propeptide

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Regulation of myostatin activity and muscle growth

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Crystal structure of BMP-9 and functional interactions with pro-region and receptors

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The prodomain of BMP-7 targets the BMP-7 complex to the extracellular matrix

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Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases.

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Cleavages within the prodomain direct intracellular trafficking and degradation of mature bone morphogenetic protein-4.

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Regulation of bone morphogenetic protein-4 activity by sequence elements within the prodomain

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The kindest cuts of all: crystal structures of Kex2 and furin reveal secrets of precursor processing

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Brachydactyly type A2 associated with a defect in proGDF5 processing

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Brachydactyly type C caused by a homozygous missense mutation in the prodomain of CDMP1.

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Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis

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TGF-beta signal transduction

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BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II

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Cooperativity of binding epitopes and receptor chains in the BMP/TGFbeta superfamily

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Osteointegration of hydroxyapatite-titanium implants coated with nonglycosylated recombinant human bone morphogenetic protein-2 (BMP-2) in aged sheep

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Structural basis of BMP signalling inhibition by the cystine knot protein Noggin

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Activation of p38 Mitogen-Activated Protein Kinase and c-Jun-NH2-Terminal Kinase by BMP-2 and Their Implication in the Stimulation of Osteoblastic Cell Differentiation

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Signal transductions induced by bone morphogenetic protein-2 and transforming growth factor-beta in normal human osteoblastic cells

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Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation.

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Structural characterization of the latent complex between transforming growth factor beta 1 and beta 1-latency-associated peptide

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A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7

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Crystal structure of the BMP-2-BRIA ectodomain complex

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The solution structure of BMPR-IA reveals a local disorder-to-order transition upon BMP-2 binding

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The recombinant proregion of transforming growth factor beta1 (latency-associated peptide) inhibits active transforming growth factor beta1 in transgenic mice.

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High-level expression of recombinant genes in Escherichia coli is dependent on the availability of the dnaY gene product

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Different routes of bone morphogenic protein (BMP) receptor endocytosis influence BMP signaling

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Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter

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Heparin inhibits BMP-2 osteogenic bioactivity by binding to both BMP-2 and BMP receptor

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Development of an enzyme-linked immunoreceptor assay (ELIRA) for quantification of the biological activity of recombinant human bone morphogenetic protein-2.

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Mesenchymal cells expressing bone morphogenetic protein receptors are present in the rheumatoid arthritis joint

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The pro domain of pre-pro-transforming growth factor beta 1 when independently expressed is a functional binding protein for the mature growth factor

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Clinical evaluation of recombinant human bone morphogenetic protein-2.

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Effect of the distribution and clustering of the type I A BMP receptor (ALK3) with the type II BMP receptor on the activation of signalling pathways

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Expression and characterization of bone morphogenetic protein-2 in Chinese hamster ovary cells

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