Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA (Q24318311)

regulation of transcription by RNA polymerase II

GOA release 2020-03-11

1 reference

Journal of Biological Chemistry

GOA release 2020-03-11

author name string

H A Bluyssen

series ordinal

1

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D E Levy

series ordinal

2

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language of work or name

English

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publication date

14 February 1997

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published in

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volume

272

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issue

7

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page(s)

4600-5

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cites work

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Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

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Components of a Stat recognition code: evidence for two layers of molecular selectivity

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ISGF3 gamma p48, a specificity switch for interferon activated transcription factors

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Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway

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Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease

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Jaks and Stats in signaling by the cytokine receptor superfamily

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Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

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The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

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The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction

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Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway

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Interferon-induced nuclear signalling by Jak protein tyrosine kinases

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Essential and non-redundant roles of p48 (ISGF3 gamma) and IRF-1 in both type I and type II interferon responses, as revealed by gene targeting studies

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Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element

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Two interferon-induced nuclear factors bind a single promoter element in interferon-stimulated genes

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Overlapping positive and negative regulatory domains of the human beta-interferon gene

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ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains

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High-frequency mutagenesis of human cells and characterization of a mutant unresponsive to both alpha and gamma interferons

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Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha

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The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction

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Combinatorial association and abundance of components of interferon-stimulated gene factor 3 dictate the selectivity of interferon responses.

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Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity

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Tyrosine-phosphorylated Stat1 and Stat2 plus a 48-kDa protein all contact DNA in forming interferon-stimulated-gene factor 3

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Application of genomic DNA affinity chromatography identifies multiple interferon-alpha-regulated Stat2 complexes

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A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain

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The interferon-stimulated gene 54 K promoter contains two adjacent functional interferon-stimulated response elements of different strength, which act synergistically for maximal interferon-alpha inducibility.

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Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor

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A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ

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Induction by EGF and interferon-gamma of tyrosine phosphorylated DNA binding proteins in mouse liver nuclei.

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Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation

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A common nuclear signal transduction pathway activated by growth factor and cytokine receptors

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Two distinct alpha-interferon-dependent signal transduction pathways may contribute to activation of transcription of the guanylate-binding protein gene

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Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons

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Isolation and characterization of a new mutant human cell line unresponsive to alpha and beta interferons

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Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins

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Two domains of ISGF3 gamma that mediate protein-DNA and protein-protein interactions during transcription factor assembly contribute to DNA-binding specificity

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Recognition DNA Sequences of Interferon Regulatory Factor 1 (IRF-1) and IRF-2, Regulators of Cell Growth and the Interferon System

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Function of Stat2 protein in transcriptional activation by alpha interferon

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7 January 2021

Activation of the human beta-interferon gene requires an interferon-inducible factor

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7 January 2021

High-efficiency transformation of mammalian cells by plasmid DNA

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Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method

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Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway

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7 January 2021

Transcriptional responses to polypeptide ligands: the JAK-STAT pathway

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Human transforming growth factor-beta 3: recombinant expression, purification, and biological activities in comparison with transforming growth factors-beta 1 and -beta 2.

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