Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway (Q24315873)

GOA release 2020-03-11

cell-cell signaling

1 reference

GOA release 2020-03-11

author name string

G S Feng

1

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Y B Ouyang

2

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D P Hu

3

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Z Q Shi

4

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R Gentz

5

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J Ni

Journal of Biological Chemistry

6

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language of work or name

English

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publication date

24 May 1996

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published in

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volume

271

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issue

21

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page(s)

12129-32

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cites work

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

1 reference

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The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

21 January 2018

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Molecular Cloning of the Mousegrb2Gene: Differential Interaction of the Grb2 Adaptor Protein with Epidermal Growth Factor and Nerve Growth Factor Receptors

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A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.

21 January 2018

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An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

21 January 2018

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Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

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The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

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Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

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Signal transduction. How receptors turn Ras on.

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Signal transduction--a conserved pathway from the membrane to the nucleus

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The human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5.

21 January 2018

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Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

21 January 2018

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A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase

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BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein

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Complementary DNA sequencing: expressed sequence tags and human genome project

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Sequence identification of 2,375 human brain genes

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SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases

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SH2 domain specificity and activity modified by a single residue

21 January 2018

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SH2 domains recognize specific phosphopeptide sequences

21 January 2018

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p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase

21 January 2018

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Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase

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SH3 domain-mediated interaction of dystroglycan and Grb2

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Binding of Vav to Grb2 through dimerization of Src homology 3 domains

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Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway

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inferred from DOI database lookup

7 January 2021

based on heuristic

Biochemical and genetic analysis of the Drk SH2/SH3 adaptor protein of Drosophila.

1 reference

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inferred from DOI database lookup

7 January 2021

based on heuristic

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.21.12129