Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1 (Q24314266)

protein serine/threonine kinase activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

S Hirabayashi

1

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K Nakagawa

2

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K Sumita

3

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S Hidaka

4

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T Kawai

5

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M Ikeda

6

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A Kawata

7

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K Ohno

8

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Y Hata

Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein

9

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language of work or name

English

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publication date

17 July 2008

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published in

Oncogene

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volume

27

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issue

31

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page(s)

4281-92

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cites work

1 reference

Human LATS1 is a mitotic exit network kinase

20 April 2017

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The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1

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Cloning and characterization of a member of the MST subfamily of Ste20-like kinases

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Human NDR kinases are rapidly activated by MOB proteins through recruitment to the plasma membrane and phosphorylation

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Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST)

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Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3

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salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines

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Cloning, expression, and mapping of hWW45, a novel human WW domain-containing gene

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Mob as tumor suppressor is activated by Hippo kinase for growth inhibition in Drosophila

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From cell structure to transcription: Hippo forges a new path

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https://api.crossref.org/works/10.1038%2FONC.2008.66

Growth regulation: a beginning for the hippo pathway

21 January 2018

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The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.66

Drosophila Mob family proteins interact with the related tricornered (Trc) and warts (Wts) kinases

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.66

NDR kinases regulate essential cell processes from yeast to humans

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Ras-association domain family protein 6 induces apoptosis via both caspase-dependent and caspase-independent pathways

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.66

The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis

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https://api.crossref.org/works/10.1038%2FONC.2008.66

Control of cell proliferation and apoptosis by mob as tumor suppressor, mats

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.66

MOB1, an Essential Yeast Gene Required for Completion of Mitosis and Maintenance of Ploidy

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.66

The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.66

Crystal structure of a human Mob1 protein: toward understanding Mob-regulated cell cycle pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.66

Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.66

hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.66

The human tumour suppressor LATS1 is activated by human MOB1 at the membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.66