Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins (Q24313402)

identical protein binding

GOA release 2020-03-11

1 reference

Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localization

GOA release 2020-03-11

Quansheng Du

1

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author name string

Ian G Macara

series ordinal

2

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language of work or name

English

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publication date

12 November 2004

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published in

Cell

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volume

119

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issue

4

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page(s)

503-16

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cites work

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A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly.

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Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous system

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Asymmetric cell division: fly neuroblast meets worm zygote

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A protein complex containing Inscuteable and the Galpha-binding protein Pins orients asymmetric cell divisions in Drosophila

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LGN blocks the ability of NuMA to bind and stabilize microtubules. A mechanism for mitotic spindle assembly regulation

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Asymmetrically distributed C. elegans homologs of AGS3/PINS control spindle position in the early embryo

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Visualization of the spatial and temporal dynamics of intracellular signaling

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Inhibition of GDP/GTP exchange on G alpha subunits by proteins containing G-protein regulatory motifs

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The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

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Polarity controls forces governing asymmetric spindle positioning in the Caenorhabditis elegans embryo

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Distinct roles for Galpha and Gbetagamma in regulating spindle position and orientation in Caenorhabditis elegans embryos

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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Asymmetric cell division in the Drosophila nervous system

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A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications

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A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization

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Asymmetric segregation of Numb: a mechanism for neural specification from Drosophila to mammals

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Parsing the polarity code

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Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis

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Orientation of spindle axis and distribution of plasma membrane proteins during cell division in polarized MDCKII cells

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NuMA is required for the organization of microtubules into aster-like mitotic arrays.

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NH2-terminal deletion of beta-catenin results in stable colocalization of mutant beta-catenin with adenomatous polyposis coli protein and altered MDCK cell adhesion

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Chromosome movement in mitosis requires microtubule anchorage at spindle poles

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Activity of Rho-family GTPases during cell division as visualized with FRET-based probes

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Identification of genes periodically expressed in the human cell cycle and their expression in tumors

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Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivo and in vitro.

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Subcellular localization of LGN during mitosis: evidence for its cortical localization in mitotic cell culture systems and its requirement for normal cell cycle progression

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A complex of LIN-5 and GPR proteins regulates G protein signaling and spindle function inC. elegans

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Translation of polarity cues into asymmetric spindle positioning in Caenorhabditis elegans embryos

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The distribution of active force generators controls mitotic spindle position

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Spindle assembly in animal cells.

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Return of the GDI: the GoLoco motif in cell division.

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Cell Polarity and the Cytoskeleton in theCaenorhabditis ElegansZygote

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A mouse homologue of Drosophila pins can asymmetrically localize and substitute for pins function in Drosophila neuroblasts

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Metaphase spindles rotate in the neuroepithelium of rat cerebral cortex.

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