cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms (Q24311676)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21737330%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

title

cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms (English)

1 reference

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7 February 2020

0 references

1 reference

2 references

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0070266

Baculoviral IAP repeat containing 3

1 reference

Toll like receptor adaptor molecule 1

1 reference

Toll like receptor 3

1 reference

Caspase 8

1 reference

Fas associated via death domain

1 reference

Receptor interacting serine/threonine kinase 3

1 reference

CASP8 and FADD like apoptosis regulator

1 reference

Receptor interacting serine/threonine kinase 1

1 reference

Caspase 10

1 reference

Baculoviral IAP repeat containing 2

1 reference

1 reference

6

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7 February 2020

author name string

Maria Feoktistova

1

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7 February 2020

Peter Geserick

2

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7 February 2020

Beate Kellert

3

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7 February 2020

Diana Panayotova Dimitrova

4

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7 February 2020

Claudia Langlais

5

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7 February 2020

Kelvin Cain

7

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7 February 2020

Marion MacFarlane

8

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7 February 2020

Georg Häcker

9

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7 February 2020

Martin Leverkus

10

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7 February 2020

language of work or name

English

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publication date

7 July 2011

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7 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21737330%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

volume

43

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7 February 2020

issue

3

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7 February 2020

page(s)

449-463

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NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling

7 February 2020

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Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

19 March 2017

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cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

19 March 2017

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Mechanisms of necroptosis in T cells

19 March 2017

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Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

19 March 2017

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RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

19 March 2017

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Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling

19 March 2017

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Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif

19 March 2017

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RIP3 mediates the embryonic lethality of caspase-8-deficient mice

19 March 2017

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Identification of RIP1 kinase as a specific cellular target of necrostatins

7 April 2017

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The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs

7 April 2017

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Cellular FLICE-inhibitory protein (cFLIP) isoforms block CD95- and TRAIL death receptor-induced gene induction irrespective of processing of caspase-8 or cFLIP in the death-inducing signaling complex

27 September 2017

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RIG-I RNA Helicase Activation of IRF3 Transcription Factor Is Negatively Regulated by Caspase-8-Mediated Cleavage of the RIP1 Protein

27 September 2017

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The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy

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Functional complementation between FADD and RIP1 in embryos and lymphocytes

27 September 2017

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FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity

27 September 2017

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c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling

27 September 2017

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27 September 2017

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27 September 2017

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Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation

27 September 2017

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Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment

27 September 2017

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Proapoptotic signalling through Toll-like receptor-3 involves TRIF-dependent activation of caspase-8 and is under the control of inhibitor of apoptosis proteins in melanoma cells

27 September 2017

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27 September 2017

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Epstein-Barr virus (EBV)-encoded small RNA is released from EBV-infected cells and activates signaling from Toll-like receptor 3.

27 September 2017

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Integrated microarray and multiplex cytokine analyses of Kaposi's Sarcoma Associated Herpesvirus viral FLICE Inhibitory Protein K13 affected genes and cytokines in human blood vascular endothelial cells

27 September 2017

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RIP kinases at the crossroads of cell death and survival

27 September 2017

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TNF-like weak inducer of apoptosis inhibits proinflammatory TNF receptor-1 signaling

27 September 2017

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The role of Toll-like receptor signaling in human immunodeficiencies

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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NF-kappaB inhibition reveals differential mechanisms of TNF versus TRAIL-induced apoptosis upstream or at the level of caspase-8 activation independent of cIAP2.

27 September 2017

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cFLIP regulation of lymphocyte activation and development

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Death receptor signaling

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cFLIPL inhibits tumor necrosis factor-related apoptosis-inducing ligand-mediated NF-kappaB activation at the death-inducing signaling complex in human keratinocytes

27 September 2017

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Activation of caspases-8 and -10 by FLIP(L).

27 September 2017

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Necrotic death pathway in Fas receptor signaling

27 September 2017

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The contact allergen nickel sensitizes primary human endothelial cells and keratinocytes to TRAIL-mediated apoptosis.

27 September 2017

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Expression of K13/v-FLIP gene of human herpesvirus 8 and apoptosis in Kaposi's sarcoma spindle cells.

30 May 2018

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Dual signaling of the Fas receptor: initiation of both apoptotic and necrotic cell death pathways

30 May 2018

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Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival

30 May 2018

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Fas-associated Death Domain Protein and Caspase-8 Are Not Recruited to the Tumor Necrosis Factor Receptor 1 Signaling Complex during Tumor Necrosis Factor-induced Apoptosis

29 November 2018

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Regulation of tumor necrosis factor-related apoptosis-inducing ligand sensitivity in primary and transformed human keratinocytes

29 November 2018

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12 December 2020

Caspase activation involves the formation of the aposome, a large (approximately 700 kDa) caspase-activating complex

1 reference

12 December 2020

Toll-like receptor 3 expressed by melanoma cells as a target for therapy?

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12 December 2020

Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes

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12 December 2020

10.1016/J.MOLCEL.2011.06.011

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21737330%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21737330%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

PubMed publication ID

21737330

2 references