Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins (Q24310801)

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Ashby O Thomas

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Mary B Goldring

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Jack Lawler

Journal of Biological Chemistry

5

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language of work or name

English

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publication date

23 September 2005

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published in

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volume

280

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issue

38

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page(s)

32655-61

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cites work

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Mutations in cartilage oligomeric matrix protein causing pseudoachondroplasia and multiple epiphyseal dysplasia affect binding of calcium and collagen I, II, and IX

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Cartilage oligomeric matrix protein is a calcium-binding protein, and a mutation in its type 3 repeats causes conformational changes

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Cartilage oligomeric matrix protein shows high affinity zinc-dependent interaction with triple helical collagen

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Mutations in exon 17B of cartilage oligomeric matrix protein (COMP) cause pseudoachondroplasia

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Structure of a thrombospondin C-terminal fragment reveals a novel calcium core in the type 3 repeats

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Proteoglycan production by immortalized human chondrocyte cell lines cultured under conditions that promote expression of the differentiated phenotype

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Integrin-regulated secretion of interleukin 4: A novel pathway of mechanotransduction in human articular chondrocytes

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The distribution of Cartilage Oligomeric Matrix Protein (COMP) in tendon and its variation with tendon site, age and load

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Cell attachment to thrombospondin: the role of ARG-GLY-ASP, calcium, and integrin receptors

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Disulfides modulate RGD-inhibitable cell adhesive activity of thrombospondin

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Increased degradation and altered tissue distribution of cartilage oligomeric matrix protein in human rheumatoid and osteoarthritic cartilage

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COMP (cartilage oligomeric matrix protein) is structurally related to the thrombospondins

30 May 2018

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Integrin expression by human articular chondrocytes

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Cartilage oligomeric matrix protein interacts with type IX collagen, and disruptions to these interactions identify a pathogenetic mechanism in a bone dysplasia family.

30 May 2018

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Effect of cartilage oligomeric matrix protein on mesenchymal chondrogenesis in vitro

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The spatial pattern of integrins during development of mouse articular cartilage.

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Integrins and extracellular matrix proteins in the human childhood and adolescent growth plate

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Mechanotransduction via integrins and interleukinâ 4 results in altered aggrecan and matrix metalloproteinase 3 gene expression in normal, but not osteoarthritic, human articular chondrocytes

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Integrin-mediated attachment of articular chondrocytes to extracellular matrix proteins

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12 December 2020

Integrin expression by human articular chondrocytes

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12 December 2020

Cartilage oligomeric matrix protein and thrombospondin 1. Purification from articular cartilage, electron microscopic structure, and chondrocyte binding

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12 December 2020

Cartilage oligomeric matrix protein (COMP) is an abundant component of tendon

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12 December 2020

Differential responses of chondrocytes from normal and osteoarthritic human articular cartilage to mechanical stimulation

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12 December 2020

Cartilage oligomeric matrix protein: Isolation and characterization from human articular cartilage

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12 December 2020

Expression of cartilage oligomeric matrix protein by human synovium

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12 December 2020

Small fragments of cartilage oligomeric matrix protein in synovial fluid and serum as markers for cartilage degradation

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12 December 2020

Hyperpolarisation of cultured human chondrocytes following cyclical pressure-induced strain: evidence of a role for alpha 5 beta 1 integrin as a chondrocyte mechanoreceptor

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12 December 2020

Changes in cartilage and bone metabolism identified by serum markers in early osteoarthritis of the knee joint

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12 December 2020

Identification of twelve mutations in cartilage oligomeric matrix protein (COMP) in patients with pseudoachondroplasia

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12 December 2020

Production of cartilage oligomeric matrix protein (COMP) by cultured human dermal and synovial fibroblasts

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12 December 2020

Distribution of cartilage molecules in the developing mouse joint

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12 December 2020

Functional genomic analysis in arthritis-affected cartilage: yin-yang regulation of inflammatory mediators by alpha 5 beta 1 and alpha V beta 3 integrins

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12 December 2020

Altered electrophysiological responses to mechanical stimulation and abnormal signalling through alpha5beta1 integrin in chondrocytes from osteoarthritic cartilage

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12 December 2020

Integrin and mechanosensitive ion channel-dependent tyrosine phosphorylation of focal adhesion proteins and beta-catenin in human articular chondrocytes after mechanical stimulation

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12 December 2020

Demonstration of fibronectin in human articular cartilage by an indirect immunoperoxidase technique

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12 December 2020

Chondrocyte-matrix interactions. Attachment to proteins isolated from cartilage

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12 December 2020

Cartilage matrix proteins. An acidic oligomeric protein (COMP) detected only in cartilage

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12 December 2020

Localization of beta 1-integrins in human cartilage and their role in chondrocyte adhesion to collagen and fibronectin

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12 December 2020