Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2 (Q24310270)

Interferon induced with helicase C domain 1

GOA release 2020-03-11

1 reference

positive regulation of interferon-beta production

GOA release 2020-03-11

1 reference

Journal of Biological Chemistry

GOA release 2020-03-11

author name string

Darja Bamming

series ordinal

1

0 references

Curt M Horvath

series ordinal

2

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language of work or name

English

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publication date

10 April 2009

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published in

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volume

284

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issue

15

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page(s)

9700-12

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describes a project that uses

ImageQuant

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2665091/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Structure and function of LGP2, a DEX(D/H) helicase that regulates the innate immunity response

19 March 2017

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The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I

19 March 2017

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Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2

19 March 2017

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RNA- and virus-independent inhibition of antiviral signaling by RNA helicase LGP2

19 March 2017

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Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif

19 March 2017

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Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

19 March 2017

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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

19 March 2017

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Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I

19 March 2017

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Toll-like receptor signalling

19 March 2017

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Helicase structure and mechanism

19 March 2017

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mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties

19 March 2017

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7 January 2021

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Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses

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Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity

19 March 2017

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Structure-based mutagenesis study of hepatitis C virus NS3 helicase

19 March 2017

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Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding

19 March 2017

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RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates

19 March 2017

1 reference

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Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

19 March 2017

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Pathogen recognition and innate immunity

19 March 2017

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Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3

19 March 2017

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The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

19 March 2017

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The human DDX and DHX gene families of putative RNA helicases

19 March 2017

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5'-Triphosphate RNA is the ligand for RIG-I

19 March 2017

1 reference

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VISA is an adapter protein required for virus-triggered IFN-beta signaling

19 March 2017

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Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses

19 March 2017

1 reference

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Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

19 March 2017

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Structural basis for RNA unwinding by the DEAD-box protein Drosophila Vasa

7 April 2017

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The DEAD-box protein family of RNA helicases

7 April 2017

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Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

7 April 2017

1 reference

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Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity

7 April 2017

1 reference

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DExD/H box RNA helicases: from generic motors to specific dissociation functions

7 April 2017

1 reference

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A conserved phenylalanine of motif IV in superfamily 2 helicases is required for cooperative, ATP-dependent binding of RNA substrates in DEAD-box proteins

7 April 2017

1 reference

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Essential role of the N-terminal domain in the regulation of RIG-I ATPase activity

27 September 2017

1 reference

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Inhibition of interferon regulatory factor 7 (IRF7)-mediated interferon signal transduction by the Kaposi's sarcoma-associated herpesvirus viral IRF homolog vIRF3.

27 September 2017

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Sendai virus defective-interfering genomes and the activation of interferon-beta

27 September 2017

1 reference

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The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2665091

Overexpression of Helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2665091

A novel role for viral-defective interfering particles in enhancing dendritic cell maturation.

27 September 2017

1 reference

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Motifs IV and V in the DEAH box splicing factor Prp22 are important for RNA unwinding, and helicase-defective Prp22 mutants are suppressed by Prp8.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2665091

Helicases: amino acid sequence comparisons and structure-function relationships

30 May 2018

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Crossref

https://api.crossref.org/works/10.1074%2FJBC.M807365200