Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination (Q24307617)

Ribonuclease H1

1 reference

5'-3' exoribonuclease 2

1 reference

transcription termination site sequence-specific DNA binding

1 reference

Nicholas Jarvis Proudfoot

author

Nicholas J Proudfoot

2

Nicholas J

Proudfoot

1 reference

19 October 2023

author name string

Konstantina Skourti-Stathaki

series ordinal

1

author given names

Konstantina

author last names

Skourti-Stathaki

1 reference

19 October 2023

Natalia Gromak

series ordinal

3

author given names

Natalia

author last names

Gromak

1 reference

Functional role for senataxin, defective in ataxia oculomotor apraxia type 2, in transcriptional regulation

19 October 2023

language of work or name

English

0 references

publication date

24 June 2011

0 references

published in

Molecular Cell

0 references

issue

6

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page(s)

794-805

0 references

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145960

The multifunctional protein p54nrb/PSF recruits the exonuclease XRN2 to facilitate pre-mRNA 3' processing and transcription termination

19 March 2017

1 reference

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Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damage

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145960

Pause sites promote transcriptional termination of mammalian RNA polymerase II

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145960

Human 5' --> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites

19 March 2017

1 reference

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DNA/RNA helicase gene mutations in a form of juvenile amyotrophic lateral sclerosis (ALS4)

19 March 2017

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Structure and function of the 5′→3′ exoribonuclease Rat1 and its activating partner Rai1

19 March 2017

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Budding yeast RNA polymerases I and II employ parallel mechanisms of transcriptional termination

19 March 2017

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19 March 2017

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CTD-dependent dismantling of the RNA polymerase II elongation complex by the pre-mRNA 3'-end processing factor, Pcf11.

19 March 2017

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The yeast Rat1 exonuclease promotes transcription termination by RNA polymerase II.

19 March 2017

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Multiple protein/protein and protein/RNA interactions suggest roles for yeast DNA/RNA helicase Sen1p in transcription, transcription-coupled DNA repair and RNA processing

19 March 2017

1 reference

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The yeast SEN1 gene is required for the processing of diverse RNA classes

19 March 2017

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Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters

19 March 2017

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Mutations in the gene encoding immunoglobulin mu-binding protein 2 cause spinal muscular atrophy with respiratory distress type 1

19 March 2017

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Multiple transcript cleavage precedes polymerase release in termination by RNA polymerase II

19 March 2017

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19 March 2017

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Pre-mRNA processing reaches back to transcription and ahead to translation

19 March 2017

1 reference

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Yeast Sen1 helicase protects the genome from transcription-associated instability.

7 April 2017

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Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis

27 September 2017

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27 September 2017

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Transcriptional termination enhances protein expression in human cells

27 September 2017

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The splicing factor SC35 has an active role in transcriptional elongation

27 September 2017

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Dynamic interactions between the promoter and terminator regions of the mammalian BRCA1 gene

27 September 2017

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27 September 2017

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Human Pcf11 enhances degradation of RNA polymerase II-associated nascent RNA and transcriptional termination

27 September 2017

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Human capping enzyme promotes formation of transcriptional R loops in vitro

27 September 2017

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Autosomal recessive cerebellar ataxias

27 September 2017

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27 September 2017

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Senataxin, the yeast Sen1p orthologue: characterization of a unique protein in which recessive mutations cause ataxia and dominant mutations cause motor neuron disease

27 September 2017

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The role of Rat1 in coupling mRNA 3'-end processing to transcription termination: implications for a unified allosteric-torpedo model

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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Senataxin, the ortholog of a yeast RNA helicase, is mutant in ataxia-ocular apraxia 2.

27 September 2017

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27 September 2017

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The putative nucleic acid helicase Sen1p is required for formation and stability of termini and for maximal rates of synthesis and levels of accumulation of small nucleolar RNAs in Saccharomyces cerevisiae

27 September 2017

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27 September 2017

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27 September 2017

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A pause site for RNA polymerase II is associated with termination of transcription

27 September 2017

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27 September 2017

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30 May 2018

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30 May 2018

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Alpha-thalassaemia caused by a poly(A) site mutation reveals that transcriptional termination is linked to 3' end processing in the human alpha 2 globin gene

30 May 2018

1 reference

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30 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145960

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29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145960

Pcf11 is a termination factor in Drosophila that dismantles the elongation complex by bridging the CTD of RNA polymerase II to the nascent transcript

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145960

Autoregulation of polypyrimidine tract binding protein by alternative splicing leading to nonsense-mediated decay

29 November 2018

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29 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/21700224

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Terminal exon definition occurs cotranscriptionally and promotes termination of RNA polymerase II

1 reference

https://pubmed.ncbi.nlm.nih.gov/21700224

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A functional mRNA polyadenylation signal is required for transcription termination by RNA polymerase II

1 reference

https://pubmed.ncbi.nlm.nih.gov/21700224

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.MOLCEL.2011.04.026

1 reference

release_znwyfxjlfrdfpnnf2sp7jtsspi

Fatcat ID

0 references

1 reference

1 reference

1 reference