Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation (Q24306868)

Werner syndrome RecQ like helicase

GOA release 2020-03-11

1 reference

negative regulation of helicase activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Kai Li

1

0 references

Alex Casta

2

0 references

Rui Wang

3

0 references

Enerlyn Lozada

4

0 references

Wei Fan

5

0 references

Susan Kane

6

0 references

Qingyuan Ge

7

0 references

Wei Gu

8

0 references

David Orren

9

0 references

Jianyuan Luo

Journal of Biological Chemistry

10

0 references

language of work or name

English

0 references

publication date

21 March 2008

0 references

published in

0 references

volume

283

0 references

issue

12

0 references

page(s)

7590-8

0 references

cites work

Genetic analysis of ageing: role of oxidative damage and environmental stresses.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

Positional cloning of the Werner's syndrome gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

The Bloom's syndrome gene product is homologous to RecQ helicases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

Mutator phenotype of Werner syndrome is characterized by extensive deletions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

Werner syndrome: molecular insights into the relationships between defective DNA metabolism, genomic instability, cancer and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

p53 Modulates the exonuclease activity of Werner syndrome protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

Regulation of the Werner helicase through a direct interaction with a subunit of protein kinase A

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

Werner helicase is localized to transcriptionally active nucleoli of cycling cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

Werner helicase relocates into nuclear foci in response to DNA damaging agents and co-localizes with RPA and Rad51.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

DNA damage-induced translocation of the Werner helicase is regulated by acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

Cellular dynamics and modulation of WRN protein is DNA damage specific

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

Negative control of p53 by Sir2alpha promotes cell survival under stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

Mammalian SIRT1 represses forkhead transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

Bioinformatic analysis of the nucleolus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

Current advances in unraveling the function of the Werner syndrome protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

RecQ helicases: suppressors of tumorigenesis and premature aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

Expression and localization of Werner syndrome protein is modulated by SIRT1 and PML.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

Physical and functional interaction between p53 and the Werner's syndrome protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

Structure of a Sir2 enzyme bound to an acetylated p53 peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

The processing of Holliday junctions by BLM and WRN helicases is regulated by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

p53 modulates RPA-dependent and RPA-independent WRN helicase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

Chromosome instability in lymphocytes from a patient with Werner's syndrome is not associated with DNA repair defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709707200

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1074/JBC.M709707200

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

18203716

1 reference

Consolidated OpenCitations Corpus – April 2017