TRF2 overexpression diminishes repair of telomeric single-strand breaks and accelerates telomere shortening in human fibroblasts (Q24301264)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1903517

regulation of single strand break repair

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1903516

positive regulation of single strand break repair

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1903518

Telomeric repeat binding factor 2

1 reference

negative regulation of telomere single strand break repair

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

Gabriele Saretzki

2

0 references

Thomas von Zglinicki

Thomas von Zglinicki

6

0 references

Torsten Richter

1

Torsten Richter

0 references

Sharon Olijslagers

5

Sharon Olijslagers

0 references

Glyn Nelson

3

Glyn Nelson

0 references

author name string

Mathias Melcher

Mechanisms of Ageing and Development

4

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language of work or name

English

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publication date

April 2007

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published in

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volume

128

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issue

4

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page(s)

340-5

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cites work

Mammalian DNA single-strand break repair: an X-ra(y)ted affair

1 reference

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7 January 2021

Preferential Accumulation of Single-Stranded Regions in Telomeres of Human Fibroblasts

1 reference

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Telomeres, telomerase, and aging: Origin of the theory

1 reference

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Mammalian telomeres end in a large duplex loop

1 reference

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7 January 2021

TRF2 Protects Human Telomeres from End-to-End Fusions

1 reference

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7 January 2021

Relief of oxidative stress by ascorbic acid delays cellular senescence of normal human and Werner syndrome fibroblast cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2007.02.003

7 January 2021

Accelerated telomere shortening in fibroblasts after extended periods of confluency.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2007.02.003

7 January 2021

DNA damage foci at dysfunctional telomeres

1 reference

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7 January 2021

Oxidative stress shortens telomeres

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2007.02.003

7 January 2021

XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2007.02.003

7 January 2021

Mitochondrial dysfunction leads to telomere attrition and genomic instability

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2007.02.003

7 January 2021

MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress

1 reference

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7 January 2021

DNA damage-induced phosphorylation of the human telomere-associated protein TRF2.

1 reference

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7 January 2021

DNA damage and repair in telomeres: relation to aging

1 reference

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7 January 2021

Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2007.02.003

7 January 2021

T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2007.02.003

7 January 2021

Telomere-bound TRF1 and TRF2 stall the replication fork at telomeric repeats

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2007.02.003

7 January 2021

Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2007.02.003

7 January 2021

Shelterin: the protein complex that shapes and safeguards human telomeres

1 reference

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7 January 2021

Molecular mechanism of nucleotide excision repair.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2007.02.003

7 January 2021

Telomere shortening in human fibroblasts is not dependent on the size of the telomeric-3'-overhang

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2007.02.003

7 January 2021

L-selegiline potentiates the cellular poly(ADP-ribosyl)ation response to ionizing radiation

1 reference

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7 January 2021

Senescence Induced by Altered Telomere State, Not Telomere Loss

1 reference

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7 January 2021

DNA polymerase beta interacts with TRF2 and induces telomere dysfunction in a murine mammary cell line

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2007.02.003

7 January 2021

Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2007.02.003

7 January 2021

The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2007.02.003

7 January 2021