PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs (Q24301026)

RNA binding motif protein 8A

GOA release 2020-03-11

1 reference

Mago homolog, exon junction complex subunit

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Michael D Diem

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Chia C Chan

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Ihab Younis

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Gideon Dreyfuss

Nature Structural & Molecular Biology

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language of work or name

English

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publication date

December 2007

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published in

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volume

14

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issue

12

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page(s)

1173-9

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cites work

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Exon junction complexes mediate the enhancing effect of splicing on mRNA expression

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Splicing enhances translation in mammalian cells: an additional function of the exon junction complex

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Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex

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Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm

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The protein Mago provides a link between splicing and mRNA localization.

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The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions

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eIF4A3 is a novel component of the exon junction complex

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An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay

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eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay

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A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay

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Quality control of mRNA function

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Y14 and hUpf3b form an NMD-activating complex

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Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements

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Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay

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A perfect message: RNA surveillance and nonsense-mediated decay

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Nonsense-mediated mRNA decay in Saccharomyces cerevisiae

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The Y14 protein communicates to the cytoplasm the position of exon-exon junctions

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Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core

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The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity

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Ce-Y14 and MAG-1, components of the exon-exon junction complex, are required for embryogenesis and germline sexual switching in Caenorhabditis elegans.

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mag-1, a homolog of Drosophila mago nashi, regulates hermaphrodite germ-line sex determination in Caenorhabditis elegans.

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Drosophila Y14 shuttles to the posterior of the oocyte and is required for oskar mRNA transport

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Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex

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Membrane-bound ribosomes of myeloma cells. I. Preparation of free and membrane-bound ribosomal fractions. Assessment of the methods and properties of the ribosomes

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The pioneer translation initiation complex is functionally distinct from but structurally overlaps with the steady-state translation initiation complex

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Messenger-RNA-binding proteins and the messages they carry

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Characterization of mammalian eIF2A and identification of the yeast homolog

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Novel characteristics of the biological properties of the yeast Saccharomyces cerevisiae eukaryotic initiation factor 2A.

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Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN).

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