PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase (Q24300915)

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28 December 2019

title

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase (English)

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28 December 2019

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GOA release 2020-03-11

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Yasemin Sancak

1

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28 December 2019

Carson C Thoreen

2

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28 December 2019

Timothy R Peterson

3

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28 December 2019

Robert A Lindquist

4

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28 December 2019

Seong A Kang

5

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28 December 2019

Steven A Carr

7

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28 December 2019

language of work or name

English

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publication date

1 March 2007

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28 December 2019

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28 December 2019

volume

25

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28 December 2019

issue

6

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28 December 2019

page(s)

903-915

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Growing roles for the mTOR pathway

28 December 2019

cites work

1 reference

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Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

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TOR signaling in growth and metabolism

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Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

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7 January 2021

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

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7 January 2021

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

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7 January 2021

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

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7 January 2021

TSC2 mediates cellular energy response to control cell growth and survival

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7 January 2021

TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

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Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

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Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

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Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

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7 January 2021

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

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7 January 2021

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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7 January 2021

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

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Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

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7 January 2021

Rheb promotes cell growth as a component of the insulin/TOR signalling network

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7 January 2021

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

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7 January 2021

mTOR and cancer: insights into a complex relationship

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7 January 2021

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

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7 January 2021

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

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7 January 2021

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

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7 January 2021

The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif

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7 January 2021

Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner

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7 January 2021

The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway

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7 January 2021

Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency

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7 January 2021

Identification of a proline-rich Akt substrate as a 14-3-3 binding partner

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7 January 2021

Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin

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7 January 2021

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

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7 January 2021

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

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7 January 2021

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

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7 January 2021

The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila

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7 January 2021

Expression of proline-rich Akt-substrate PRAS40 in cell survival pathway and carcinogenesis.

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Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

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Identifiers

DOI

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17386266%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017