Interleukin-21 activates human natural killer cells and modulates their surface receptor expression (Q24300519)

Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer

GOA release 2020-03-11

author name string

Kresten Skak

series ordinal

1

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Klaus Stensgaard Frederiksen

series ordinal

2

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Dorthe Lundsgaard

series ordinal

3

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language of work or name

English

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publication date

April 2008

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published in

Immunology

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volume

123

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issue

4

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page(s)

575-83

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2433320

IL-21 induces both rapid maturation of human CD34+ cell precursors towards NK cells and acquisition of surface killer Ig-like receptors

19 March 2017

1 reference

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Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

19 March 2017

1 reference

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IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production

19 March 2017

1 reference

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Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation

19 March 2017

1 reference

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IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21

19 March 2017

1 reference

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IL-21 induces the functional maturation of murine NK cells

19 March 2017

1 reference

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An open-label, two-arm, phase I trial of recombinant human interleukin-21 in patients with metastatic melanoma

19 March 2017

1 reference

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Interleukin 21 therapy increases the density of tumor infiltrating CD8+ T cells and inhibits the growth of syngeneic tumors

27 September 2017

1 reference

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What is natural in natural killer cells?

27 September 2017

1 reference

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IL-21 enhances tumor-specific CTL induction by anti-DR5 antibody therapy

27 September 2017

1 reference

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Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity

27 September 2017

1 reference

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A novel dendritic cell subset involved in tumor immunosurveillance

27 September 2017

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IL-21 enhances tumor rejection through a NKG2D-dependent mechanism

27 September 2017

1 reference

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Killer cell immunoglobulin-like receptor diversity: balancing signals in the natural killer cell response

27 September 2017

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IL-21 induces tumor rejection by specific CTL and IFN-gamma-dependent CXC chemokines in syngeneic mice

27 September 2017

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Functional significance of the perforin/granzyme cell death pathway

27 September 2017

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Factors regulating the cytotoxic activity of the human natural killer cell line, NK-92.

27 September 2017

1 reference

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IL-21 down-regulates NKG2D/DAP10 expression on human NK and CD8+ T cells

27 September 2017

1 reference

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Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis

30 May 2018

1 reference

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Interleukin (IL)-21 and IL-15 genetic transfer synergistically augments therapeutic antitumor immunity and promotes regression of metastatic lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2007.02730.X

NK cells stimulate proliferation of T and NK cells through 2B4/CD48 interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2007.02730.X

Effect of IL-21 on NK cells derived from different umbilical cord blood populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2007.02730.X

Novel insights on human NK cells' immunological modalities revealed by gene expression profiling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2007.02730.X

IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity

21 January 2018

1 reference

12 December 2020

In vivo antitumor activity of interleukin 21 mediated by natural killer cells

1 reference

12 December 2020

NKp46 is the major triggering receptor involved in the natural cytotoxicity of fresh or cultured human NK cells. Correlation between surface density of NKp46 and natural cytotoxicity against autologous, allogeneic or xenogeneic target cells

1 reference

12 December 2020

2B4/CD48-mediated regulation of lymphocyte activation and function

1 reference

12 December 2020

Multiple cytokines regulate the NK gene complex-encoded receptor repertoire of mature NK cells and T cells

1 reference

12 December 2020

CD27 dissects mature NK cells into two subsets with distinct responsiveness and migratory capacity

1 reference

12 December 2020