Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism (Q24300310)

angiotensin I converting enzyme

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Membrane metalloendopeptidase

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carboxypeptidase activity

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Gillian I Rice

1

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Nigel Mark Hooper

object named as

Nigel M Hooper

5

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author name string

Daniel A Thomas

2

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Peter J Grant

3

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Anthony J Turner

A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9

4

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language of work or name

English

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publication date

1 October 2004

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published in

Biochemical Journal

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volume

383

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issue

Pt 1

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page(s)

45-51

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cites work

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A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase

19 March 2017

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Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning

19 March 2017

1 reference

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The two homologous domains of human angiotensin I-converting enzyme are both catalytically active

19 March 2017

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Measurement of protein using bicinchoninic acid

19 March 2017

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Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase

19 March 2017

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Expression and characterization of recombinant human angiotensin I-converting enzyme. Evidence for a C-terminal transmembrane anchor and for a proteolytic processing of the secreted recombinant and plasma enzymes

19 March 2017

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Angiotensin-converting enzyme 2 is an essential regulator of heart function

19 March 2017

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Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysin

19 March 2017

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Roles of the two active sites of somatic angiotensin-converting enzyme in the cleavage of angiotensin I and bradykinin: insights from selective inhibitors

19 March 2017

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The role of ACE2 in cardiovascular physiology

27 September 2017

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Vasopeptidase inhibition: a double-edged sword?

27 September 2017

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Products of angiotensin I hydrolysis by human cardiac enzymes potentiate bradykinin

27 September 2017

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Heart failure: recent advances in prevention and treatment.

27 September 2017

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The angiotensin-converting enzyme gene family: genomics and pharmacology

27 September 2017

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The neprilysin (NEP) family of zinc metalloendopeptidases: genomics and function

27 September 2017

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Shedding of somatic angiotensin-converting enzyme (ACE) is inefficient compared with testis ACE despite cleavage at identical stalk sites.

27 September 2017

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Essential hypertension : part II: treatment

27 September 2017

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RXP 407, a phosphinic peptide, is a potent inhibitor of angiotensin I converting enzyme able to differentiate between its two active sites

27 September 2017

1 reference

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Molecular biology of the angiotensin I converting enzyme: I. Biochemistry and structure of the gene.

27 September 2017

1 reference

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The angiotensin type 1 and type 2 receptor families. Siblings or cousins?

27 September 2017

1 reference

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Neutral endopeptidase 24.11 (enkephalinase) and related regulators of peptide hormones

27 September 2017

1 reference

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Structure of the angiotensin I-converting enzyme gene. Two alternate promoters correspond to evolutionary steps of a duplicated gene.

27 September 2017

1 reference

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Counterregulatory Actions of Angiotensin-(1-7)

27 September 2017

1 reference

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Purification of angiotensin-converting enzyme from rabbit lung and human plasma by affinity chromatography

30 May 2018

1 reference

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Inhibition of rabbit lung angiotensin-converting enzyme by N alpha-[(S)-1-carboxy-3-phenylpropyl]L-alanyl-L-proline and N alpha-[(S)-1-carboxy-3-phenylpropyl]L-lysyl-L-proline.

30 May 2018

1 reference

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Pig kidney angiotensin converting enzyme. Purification and characterization of amphipathic and hydrophilic forms of the enzyme establishes C-terminal anchorage to the plasma membrane

30 May 2018

1 reference

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Inhibition by converting enzyme inhibitors of pig kidney aminopeptidase P

30 May 2018

1 reference

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17 The kinetics of reversible tight-binding inhibition

30 May 2018

1 reference

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Angiotensin-converting enzyme-2 (ACE2): comparative modeling of the active site, specificity requirements, and chloride dependence

30 May 2018

1 reference

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Increased angiotensin-(1-7)-forming activity in failing human heart ventricles: evidence for upregulation of the angiotensin-converting enzyme Homologue ACE2.

29 November 2018

1 reference

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Angiotensin-(1-7) formation in the intact human heart: in vivo dependence on angiotensin II as substrate

29 November 2018

1 reference

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Evidence for the negative cooperativity of the two active sites within bovine somatic angiotensin-converting enzyme

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134042

29 November 2018

Two ACEs and a heart.

1 reference

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Angiotensin 1-9 and 1-7 release in human heart: role of cathepsin A.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134042

Selective inhibition of the C-domain of angiotensin I converting enzyme by bradykinin potentiating peptides

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134042

Arg(1098) is critical for the chloride dependence of human angiotensin I-converting enzyme C-domain catalytic activity.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134042

Angiotensin converting enzyme and angiotensin II type 1-receptor gene polymorphisms and risk of ischaemic heart disease.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134042

A pair of ACEs, for openers?

29 November 2018

1 reference

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Effects of the N-terminal sequence of ACE on the properties of its C-domain

1 reference

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A zinc metalloendopeptidase associated with dog pancreatic membranes

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An alternative strategy for the radioimmunoassay of angiotensin peptides using amino-terminal-directed antisera: measurement of eight angiotensin peptides in human plasma

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Isolation of acein-2, a novel angiotensin-I-converting enzyme inhibitory peptide derived from a tryptic hydrolysate of human plasma

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Human kidney "enkephalinase", a neutral metalloendopeptidase that cleaves active peptides

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The Renin-Angiotensin and fibrinolytic systems co-conspirators in the pathogenesis of ischemic cardiovascular disease

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Regulation of local angiotensin II formation in the human heart in the presence of interstitial fluid. Inhibition of chymase by protease inhibitors of interstitial fluid and of angiotensin-converting enzyme by Ang-(1-9) formed by heart carboxypeptid

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N-domain-specific substrate and C-domain inhibitors of angiotensin-converting enzyme: angiotensin-(1-7) and keto-ACE

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Characteristics of angiotensin converting enzyme and its role in the metabolism of angiotensin I by endothelium

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Cell biology and genetics of angiotensin in cardiovascular disease

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Hypothesis: ACE2 modulates blood pressure in the mammalian organism

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