The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway (Q24298942)

GOA release 2020-03-11

protein stabilization

1 reference

GOA release 2020-03-11

author

Julien Moretti

Jean-Christophe Olivo-Marin

5

0 references

6

object named as

Jean-Christophe Olivo-Marin

0 references

Alain Israel

7

object named as

Alain Israël

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author name string

Neetu Gupta-Rossi

1

0 references

Sara Ortica

2

0 references

Vannary Meas-Yedid

3

0 references

Sara Heuss

Journal of Biological Chemistry

4

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language of work or name

English

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publication date

27 May 2011

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published in

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volume

286

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issue

21

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page(s)

18720-30

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cites work

AAK1 regulates Numb function at an early step in clathrin-mediated endocytosis

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AIP4/Itch regulates Notch receptor degradation in the absence of ligand

19 March 2017

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A novel AAK1 splice variant functions at multiple steps of the endocytic pathway

19 March 2017

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Differential requirements for AP-2 in clathrin-mediated endocytosis

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Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis

19 March 2017

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Phosphorylation of the AP2 mu subunit by AAK1 mediates high affinity binding to membrane protein sorting signals

19 March 2017

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Numb is an endocytic protein

19 March 2017

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The Notch1 receptor is cleaved constitutively by a furin-like convertase

19 March 2017

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Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module

19 March 2017

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Intracellular Cleavage of Notch Leads to a Heterodimeric Receptor on the Plasma Membrane

19 March 2017

1 reference

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The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity

19 March 2017

1 reference

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Phosphorylation of Numb regulates its interaction with the clathrin-associated adaptor AP-2

19 March 2017

1 reference

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AAK1‐Mediated μ2 Phosphorylation is Stimulated by Assembled Clathrin

19 March 2017

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Epsins: adaptors in endocytosis?

19 March 2017

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Molecular architecture and functional model of the endocytic AP2 complex

19 March 2017

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Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor

19 March 2017

1 reference

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A conserved clathrin assembly motif essential for synaptic vesicle endocytosis

19 March 2017

1 reference

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Identification of the universal cofactor (auxilin 2) in clathrin coat dissociation

19 March 2017

1 reference

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A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

19 March 2017

1 reference

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Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro

19 March 2017

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

19 March 2017

1 reference

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Novel protein kinases Ark1p and Prk1p associate with and regulate the cortical actin cytoskeleton in budding yeast.

19 March 2017

1 reference

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Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

RBP-L, a transcription factor related to RBP-Jkappa

19 March 2017

1 reference

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Control of daughter cell fates during asymmetric division: interaction of Numb and Notch

19 March 2017

1 reference

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Signalling downstream of activated mammalian Notch

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

The canonical Notch signaling pathway: unfolding the activation mechanism

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

Notch signalling: a simple pathway becomes complex

7 April 2017

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A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

Endocytosis and intracellular trafficking of Notch and its ligands

7 April 2017

1 reference

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γ-secretase-dependent cleavage initiates notch signaling from the plasma membrane

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

Endocytic internalization routes required for delta/notch signaling

27 September 2017

1 reference

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Numb regulates post-endocytic trafficking and degradation of Notch1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

An endosomally localized isoform of Eps15 interacts with Hrs to mediate degradation of epidermal growth factor receptor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

Endosomal entry regulates Notch receptor activation in Drosophila melanogaster

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

Notch signaling--constantly on the move

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

Lethal giant discs, a novel C2-domain protein, restricts notch activation during endocytosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

Regulation of Notch signalling by endocytosis and endosomal sorting

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

Phosphatidylinositol-(4,5)-bisphosphate regulates sorting signal recognition by the clathrin-associated adaptor complex AP2.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

The notch ligand Delta1 recruits Dlg1 at cell-cell contacts and regulates cell migration.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

Clathrin promotes incorporation of cargo into coated pits by activation of the AP2 adaptor micro2 kinase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

A conserved catalytic residue in the ubiquitin-conjugating enzyme family.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

Structural insights into clathrin-mediated endocytosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

Numb-Associated Kinase Interacts with the Phosphotyrosine Binding Domain of Numb and Antagonizes the Function of Numb In Vivo

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

The shortest path from the surface to the nucleus: RBP-J kappa/Su(H) transcription factor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

SEL-5, a serine/threonine kinase that facilitates lin-12 activity in Caenorhabditis elegans

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

Requirement for dynamin during Notch signaling in Drosophila neurogenesis.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

The tyrosine kinase substrate eps15 is constitutively associated with the plasma membrane adaptor AP-2

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

Drosophila HOPS and AP-3 complex genes are required for a Deltex-regulated activation of notch in the endosomal trafficking pathway

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

The conserved c2 domain protein lethal (2) giant discs regulates protein trafficking in Drosophila

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

Endocytosis-mediated downregulation of LIN-12/Notch upon Ras activation in Caenorhabditis elegans

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099689

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21464124

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A novel AP-2 adaptor interaction motif initially identified in the long-splice isoform of synaptojanin 1, SJ170

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21464124