Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase (Q24296766)

GO:0036048

protein demalonylation

1 reference

peptidyl-lysine demalonylation

GO:0036046

1 reference

protein-succinyllysine desuccinylase activity

GO:0036047

1 reference

peptidyl-lysine desuccinylation

GO:0036055

1 reference

protein-malonyllysine demalonylase activity

GO:0036049

1 reference

peptidyl-lysine malonylation

GO:0036054

1 reference

2''-O-succinyl-ADP-D-ribose(3-)

GO:0044392

1 reference

2''-O-malonyl-ADP-D-ribose(3-)

ChEBI release 2020-05-28

ChEBI ID

87832

1 reference

ChEBI release 2020-05-28

1 reference

GOA release 2020-03-11

protein deacetylation

1 reference

GOA release 2020-03-11

Sirtuin 5

1 reference

GOA release 2020-03-11

author

Johan Auwerx

15

0 references

Jungwoo Kim

object named as

Jungwoo Kim

7

0 references

Xiaoyang Su

object named as

Xiaoyang Su

3

0 references

Quan Hao

object named as

Quan Hao

16

0 references

author name string

Jintang Du

1

0 references

Yeyun Zhou

2

0 references

Jiu Jiu Yu

4

0 references

Saba Khan

5

0 references

Hong Jiang

6

0 references

Jimin Woo

8

0 references

Jun Huyn Kim

9

0 references

Brian Hyun Choi

10

0 references

Bin He

11

0 references

Wei Chen

12

0 references

Sheng Zhang

13

0 references

Richard A Cerione

14

0 references

Hening Lin

Regulation of cellular metabolism by protein lysine acetylation

17

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language of work or name

English

0 references

publication date

11 November 2011

0 references

published in

Science

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volume

334

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issue

6057

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page(s)

806-9

0 references

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3217313

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3217313

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3217313

Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3217313

Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3217313

Structural Insights into Intermediate Steps in the Sir2 Deacetylation Reaction

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3217313

Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3217313

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3217313

Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3217313

Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3217313

SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3217313

Chemistry of gene silencing: the mechanism of NAD+-dependent deacetylation reactions

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3217313

The CCP4 suite: programs for protein crystallography

19 March 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1207861

Substrate and functional diversity of lysine acetylation revealed by a proteomics survey

22 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1207861

Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux

22 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3217313

Mammalian sirtuins: biological insights and disease relevance

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3217313

Identification of lysine succinylation as a new post-translational modification

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3217313

Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3217313

Malonyl-CoA, a key signaling molecule in mammalian cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3217313

The biochemistry of sirtuins.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3217313

Sir2 protein deacetylases: evidence for chemical intermediates and functions of a conserved histidine.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3217313

Regulation of mammalian acetyl-coenzyme A carboxylase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3217313

Mechanism-based inhibition of Sir2 deacetylases by thioacetyl-lysine peptide

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3217313

Simultaneous quantification of malonyl-CoA and several other short-chain acyl-CoAs in animal tissues by ion-pairing reversed-phase HPLC/MS.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3217313

Insights into the Sirtuin Mechanism from Ternary Complexes Containing NAD+ and Acetylated Peptide

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3217313

The Structural Basis of Sirtuin Substrate Affinity†,‡

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3217313

Probing the active site of homoserine trans-succinylase

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3217313

Nepsilon-thioacetyl-lysine: a multi-facet functional probe for enzymatic protein lysine Nepsilon-deacetylation

29 November 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1207861

7 January 2021

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1207861

7 January 2021

Investigating the ADP-ribosyltransferase activity of sirtuins with NAD analogues and 32P-NAD.

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1207861

7 January 2021

Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1207861

7 January 2021

Identifiers

DOI

10.1126/SCIENCE.1207861

1 reference

ADS bibcode

2011Sci...334..806D

0 references

1 reference

1 reference

PubMed publication ID

22076378

1 reference