Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference (Q24294614)

GOA release 2020-03-11

Arrestin beta 2

1 reference

G protein-coupled receptor internalization

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

1 reference

5

Robert J Lefkowitz

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author name string

Seungkirl Ahn

1

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Christopher D Nelson

2

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Tiffany Runyan Garrison

3

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William E Miller

Proceedings of the National Academy of Sciences of the United States of America

4

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language of work or name

English

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publication date

18 February 2003

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published in

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volume

100

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issue

4

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page(s)

1740-4

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cites work

Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds

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beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2

19 March 2017

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The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis

19 March 2017

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beta-Arrestin: a protein that regulates beta-adrenergic receptor function

19 March 2017

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

19 March 2017

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beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking

6 April 2017

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Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3

19 March 2017

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Identification of NSF as a beta-arrestin1-binding protein. Implications for beta2-adrenergic receptor regulation

19 March 2017

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G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization

19 March 2017

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Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family

19 March 2017

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Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor

19 March 2017

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Beta-arrestin2 is critically involved in CXCR4-mediated chemotaxis, and this is mediated by its enhancement of p38 MAPK activation

7 April 2017

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Gene silencing in mammals by small interfering RNAs

27 September 2017

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Activation and targeting of mitogen-activated protein kinases by G-protein-coupled receptors.

27 September 2017

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The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals

27 September 2017

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New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades

27 September 2017

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Expanding roles for beta-arrestins as scaffolds and adapters in GPCR signaling and trafficking.

27 September 2017

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Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors

27 September 2017

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Characterization of G protein-coupled receptor regulation in antisense mRNA-expressing cells with reduced arrestin levels

27 September 2017

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Heptahelical receptor signaling: beyond the G protein paradigm.

27 September 2017

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The tyrosine within the NPXnY motif of the human angiotensin II type 1 receptor is involved in mediating signal transduction but is not essential for internalization.

27 September 2017

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Dynamin and beta-arrestin reveal distinct mechanisms for G protein-coupled receptor internalization

27 September 2017

1 reference

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A simple direct assay for cyclic AMP in plasma and other biological samples using an improved competitive protein binding technique.

27 September 2017

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beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation

30 May 2018

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12 December 2020

A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration

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12 December 2020

The role of receptor kinases and arrestins in G protein-coupled receptor regulation

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12 December 2020

G protein-coupled receptor kinases

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12 December 2020

Identifiers

DOI

10.1073/PNAS.262789099

1 reference

ADS bibcode

2003PNAS..100.1740A

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1 reference

1 reference

PubMed publication ID

12582207

1 reference