PHLPP-Mediated Dephosphorylation of S6K1 Inhibits Protein Translation and Cell Growth (Q24292938)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21986499

14 December 2024

author name string

Jianyu Liu

1

1 reference

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14 December 2024

Xin Li

3

1 reference

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14 December 2024

Tianyan Gao

5

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14 December 2024

Payton D. Stevens

2

1 reference

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14 December 2024

Micheal D. Schmidt

4

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14 December 2024

language of work or name

English

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publication date

December 2011

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10 October 2011

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full work available at URL

14 December 2024

https://mcb.asm.org/content/mcb/31/24/4917.full.pdf

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21986499

https://europepmc.org/articles/PMC3233022

14 December 2024

file format

HyperText Markup Language

online access status

open access

content deliverer

1 reference

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https://europepmc.org/articles/PMC3233022?pdf=render

14 December 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21986499

https://doi.org/10.1128/mcb.05799-11

14 December 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21986499

https://journals.asm.org/doi/pdf/10.1128/MCB.05799-11

14 December 2024

1 reference

https://api.crossref.org/works/10.1128/MCB.05799-11

https://www.tandfonline.com/doi/pdf/10.1128/MCB.05799-11

14 December 2024

1 reference

https://api.crossref.org/works/10.1128/MCB.05799-11

Molecular and Cellular Biology

14 December 2024

published in

0 references

volume

31

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issue

24

0 references

page(s)

4917-27

0 references

cites work

Mst1 is an interacting protein that mediates PHLPPs' induced apoptosis

1 reference

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Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis

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PHLiPPing the switch on Akt and protein kinase C signaling

19 March 2017

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

19 March 2017

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The phosphatase PHLPP controls the cellular levels of protein kinase C

19 March 2017

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PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms

19 March 2017

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Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

19 March 2017

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Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

19 March 2017

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Phosphorylation and activation of p70s6k by PDK1

19 March 2017

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Rag proteins regulate amino-acid-induced mTORC1 signalling.

19 March 2017

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

19 March 2017

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Protein phosphatase PHLPP1 controls the light-induced resetting of the circadian clock

19 March 2017

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

19 March 2017

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mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

19 March 2017

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PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

19 March 2017

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The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

19 March 2017

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Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis

19 March 2017

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Targeting PI3K signalling in cancer: opportunities, challenges and limitations

19 March 2017

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Molecular mechanisms of mTOR-mediated translational control

7 April 2017

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Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

7 April 2017

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Ras, PI(3)K and mTOR signalling controls tumour cell growth

7 April 2017

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mTOR-dependent regulation of PHLPP expression controls the rapamycin sensitivity in cancer cells

7 April 2017

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mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs

27 September 2017

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Ribosomal protein S6 kinase from TOP mRNAs to cell size

27 September 2017

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beta-TrCP-mediated ubiquitination and degradation of PHLPP1 are negatively regulated by Akt.

27 September 2017

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27 September 2017

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From promiscuity to precision: protein phosphatases get a makeover

27 September 2017

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Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

27 September 2017

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RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation

27 September 2017

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27 September 2017

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27 September 2017

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PP2A regulatory subunit PP2A-B' counteracts S6K phosphorylation.

30 May 2018

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Preparation, culture, and immortalization of mouse embryonic fibroblasts

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1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21986499

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.05799-11

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21986499

14 December 2024

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21986499

14 December 2024

1 reference

National Center for Biotechnology Information