Statins for the treatment of Alzheimer's disease and dementia (Q24240305)

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object named as

Bernadette McGuinness

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author name string

Roger Bullock

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David Craig

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Enda Kerr

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Peter Passmore

Cochrane Database of Systematic Reviews

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language of work or name

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21 January 2009

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published in

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cites work

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Isoprenoids as mediators of the biological effects of statins

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Serum Cholesterol and Intellectual Performance

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Cholesterol and Alzheimer's disease: is there a link?

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Amyloidogenic processing of beta-amyloid precursor protein in intracellular compartments

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HMG-CoA reductase inhibitors improve endothelial dysfunction in normocholesterolemic hypertension via reduced production of reactive oxygen species

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Incidence and risk factors of vascular dementia and Alzheimer's disease in a defined elderly Japanese population: the Hisayama Study

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Aging and the occurrence of dementia: findings from a population-based cohort with a large sample of nonagenarians

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Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

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7 January 2021

Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people.

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7 January 2021

Relation of plasma lipids to Alzheimer disease and vascular dementia

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7 January 2021

Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported.

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7 January 2021

Brain infarction and the clinical expression of Alzheimer disease. The Nun Study

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7 January 2021

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium

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7 January 2021

Low-Density Lipoprotein Cholesterol and the Risk of Dementia With Stroke

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7 January 2021

Statins for the reduction of risk of Alzheimer's disease

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Association between high-density lipoprotein and cognitive impairment in the oldest old.

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Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial

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7 January 2021

Apolipoprotein E4 induces neuronal cell death under conditions of suppressed de novo cholesterol synthesis

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7 January 2021

Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol

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7 January 2021

Ischemic stress induces deposition of amyloid beta immunoreactivity in human brain

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7 January 2021

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7 January 2021

Serum paraoxonase activity changes in patients with Alzheimer's disease and vascular dementia

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7 January 2021

Brain region-dependent increases in beta-amyloid and apolipoprotein E levels in hypercholesterolemic rabbits

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7 January 2021

Cortical senile plaques in coronary artery disease, aging and Alzheimer's disease

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7 January 2021

Characterization of stable complexes involving apolipoprotein E and the amyloid beta peptide in Alzheimer's disease brain.

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7 January 2021

Randomized trial of the effects of simvastatin on cognitive functioning in hypercholesterolemic adults

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7 January 2021

Vascular factors in dementia: an overview

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7 January 2021

Cholesterol in neurologic disorders of the elderly: stroke and Alzheimer's disease

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7 January 2021

Effects of lovastatin on cognitive function and psychological well-being

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7 January 2021

Enhanced oxidizability of ubiquinol and α‐tocopherol during lovastatin treatment

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7 January 2021

Plasma antioxidant activity and vascular dementia

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7 January 2021

Statins and the risk of dementia

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7 January 2021

MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial

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7 January 2021

Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial

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7 January 2021

Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins

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7 January 2021

Global prevalence of dementia: a Delphi consensus study

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7 January 2021

High-density lipoprotein cholesterol in differential diagnosis of senile dementia.

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7 January 2021

Is Alzheimer's disease an apolipoprotein E amyloidosis?

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7 January 2021

Smoking and risk of dementia and Alzheimer's disease in a population-based cohort study: the Rotterdam Study

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7 January 2021

Co-localization of cholesterol, apolipoprotein E and fibrillar Abeta in amyloid plaques

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7 January 2021

Type 2 diabetes mellitus, cognitive impairment and dementia.

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7 January 2021

New possible role of statins in age-related diseases

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7 January 2021

Bias in treatment assignment in controlled clinical trials.

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7 January 2021

High-dose atorvastatin after stroke or transient ischemic attack

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7 January 2021

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

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7 January 2021

A fluid connection: cholesterol and Abeta

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7 January 2021

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease

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7 January 2021

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

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7 January 2021

Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein

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7 January 2021

Cholesterol-dependent Generation of a Seeding Amyloid β-Protein in Cell Culture

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https://api.crossref.org/works/10.1002%2F14651858.CD007514

7 January 2021

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes

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https://api.crossref.org/works/10.1002%2F14651858.CD007514

7 January 2021

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

1 reference

https://api.crossref.org/works/10.1002%2F14651858.CD007514

7 January 2021

Serum cholesterol concentrations are associated with visuomotor speed in men: findings from the third National Health and Nutrition Examination Survey, 1988-1994.

1 reference

https://api.crossref.org/works/10.1002%2F14651858.CD007514

7 January 2021

The role of cholesterol in the biosynthesis of beta-amyloid

1 reference

https://api.crossref.org/works/10.1002%2F14651858.CD007514

7 January 2021

Statins in the prevention and treatment of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1002%2F14651858.CD007514

7 January 2021

Cholesterol metabolism in the brain

1 reference

https://api.crossref.org/works/10.1002%2F14651858.CD007514

7 January 2021

Do statins slow down Alzheimer's disease? A review

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https://api.crossref.org/works/10.1002%2F14651858.CD007514

7 January 2021

Effect of vascular lesions on cognition in Alzheimer's disease: a community-based study

1 reference

https://api.crossref.org/works/10.1002%2F14651858.CD007514

7 January 2021

Circulating cholesterol levels, apolipoprotein E genotype and dementia severity influence the benefit of atorvastatin treatment in Alzheimer's disease: results of the Alzheimer's Disease Cholesterol-Lowering Treatment (ADCLT) trial.

1 reference

https://api.crossref.org/works/10.1002%2F14651858.CD007514

7 January 2021

Paraoxonase 1 activity: a new vascular marker of dementia?

1 reference

https://api.crossref.org/works/10.1002%2F14651858.CD007514

7 January 2021

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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https://api.crossref.org/works/10.1002%2F14651858.CD007514

7 January 2021

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

1 reference

https://api.crossref.org/works/10.1002%2F14651858.CD007514

7 January 2021

Lipid lowering agents are associated with a slower cognitive decline in Alzheimer's disease

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https://api.crossref.org/works/10.1002%2F14651858.CD007514

7 January 2021

Neuropathological assessment of the lesions of significance in vascular dementia

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https://api.crossref.org/works/10.1002%2F14651858.CD007514

7 January 2021

Alzheimer's disease: genes, proteins, and therapy

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https://api.crossref.org/works/10.1002%2F14651858.CD007514

7 January 2021

Neuropathological substrates of dementia and depression in vascular dementia, with a particular focus on cases with small infarct volumes.

1 reference

https://api.crossref.org/works/10.1002%2F14651858.CD007514

7 January 2021

Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1002%2F14651858.CD007514

7 January 2021

Prevention and treatment of dementia or Alzheimer's disease by statins: a meta-analysis

1 reference

https://api.crossref.org/works/10.1002%2F14651858.CD007514

7 January 2021

Associations of lipoprotein cholesterols, apolipoproteins A-I and B, and triglycerides with carotid atherosclerosis and coronary heart disease. The Atherosclerosis Risk in Communities (ARIC) Study.

1 reference

https://api.crossref.org/works/10.1002%2F14651858.CD007514

7 January 2021

Subchronic toxicity of atorvastatin, a hydroxymethylglutaryl-coenzyme A reductase inhibitor, in beagle dogs

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https://api.crossref.org/works/10.1002%2F14651858.CD007514

7 January 2021

Lipoprotein profile in older patients with vascular dementia and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1002%2F14651858.CD007514

7 January 2021

The Alzheimer's disease beta-secretase enzyme, BACE1.

1 reference

https://api.crossref.org/works/10.1002%2F14651858.CD007514

7 January 2021

Lipid homeostasis and apolipoprotein E in the development and progression of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1002%2F14651858.CD007514

7 January 2021

Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain.

1 reference

https://api.crossref.org/works/10.1002%2F14651858.CD007514

7 January 2021

Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1002%2F14651858.CD007514

7 January 2021

Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: a case-control study

1 reference

https://api.crossref.org/works/10.1002%2F14651858.CD007514

7 January 2021

Cognitive impairment associated with atorvastatin and simvastatin

1 reference

https://api.crossref.org/works/10.1002%2F14651858.CD007514

7 January 2021

Statin-associated memory loss: analysis of 60 case reports and review of the literature

1 reference

https://api.crossref.org/works/10.1002%2F14651858.CD007514

7 January 2021

Effects of statins on cognitive function in patients with Alzheimer's disease in galantamine clinical trials

1 reference

https://api.crossref.org/works/10.1002%2F14651858.CD007514

7 January 2021