Substitutions for hydrophobic amino acids in the N-terminal domains of IGFBP-3 and -5 markedly reduce IGF-I binding and alter their biologic actions (Q22253898)

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Language	Label	Description	Also known as
English	Substitutions for hydrophobic amino acids in the N-terminal domains of IGFBP-3 and -5 markedly reduce IGF-I binding and alter their biologic actions	scientific article

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scholarly article

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Substitutions for hydrophobic amino acids in the N-terminal domains of IGFBP-3 and -5 markedly reduce IGF-I binding and alter their biologic actions (English)

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Insulin like growth factor 1

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GOA release 2020-03-11

Insulin like growth factor binding protein 5

1 reference

GOA release 2020-03-11

Insulin like growth factor binding protein 3

1 reference

GOA release 2020-03-11

negative regulation of smooth muscle cell proliferation

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GOA release 2020-03-11

1 reference

based on heuristic

inferred from title

author name string

Y Imai

1

author given names

Y

author last names

Imai

1 reference

PubMed publication ID

29 March 2023

A Moralez

2

author given names

A

author last names

Moralez

1 reference

PubMed publication ID

29 March 2023

U Andag

3

author given names

U

author last names

Andag

1 reference

PubMed publication ID

29 March 2023

J B Clarke

4

author given names

J B

author last names

Clarke

1 reference

PubMed publication ID

29 March 2023

W H Busby

5

author given names

W H Jr

author last names

Busby

1 reference

PubMed publication ID

29 March 2023

D R Clemmons

6

author given names

D R

author last names

Clemmons

1 reference

PubMed publication ID

29 March 2023

language of work or name

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publication date

16 June 2000

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Journal of Biological Chemistry

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275

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24

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18188-94

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Extracellular matrix contains insulin-like growth factor binding protein-5: potentiation of the effects of IGF-I

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The ontogeny and regulation of a 31,000 molecular weight insulin-like growth factor-binding protein in fetal porcine plasma and sera

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21 January 2018

A 3-dimensional model for the insulin-like growth factor binding proteins (IGFBPs); supporting evidence using the structural determinants of the IGF binding site on IGFBP-3.

1 reference

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21 January 2018

Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions

1 reference

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21 January 2018

Binding Sites and Binding Properties of Binary and Ternary Complexes of Insulin-like Growth Factor-II (IGF-II), IGF-binding Protein-3, and Acid-labile Subunit

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Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) functions as an IGF-reversible inhibitor of IGFBP-4 proteolysis

1 reference

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21 January 2018

IGF binding proteins and their functions

1 reference

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Insulin-like growth factor binding protein proteolysis in bone cell models

1 reference

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21 January 2018

Insulin-like growth factor binding proteins and their role in controlling IGF actions

1 reference

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21 January 2018

Biosensor measurement of the binding of insulin-like growth factors I and II and their analogues to the insulin-like growth factor-binding protein-3.

1 reference

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21 January 2018

Solution structure of human insulin-like growth factor 1: a nuclear magnetic resonance and restrained molecular dynamics study

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Isolation of a biologically active fragment from the carboxy terminus of the fetal rat binding protein for insulin-like growth factors

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Insulin-like growth factor-II participates in the biphasic effect of a gonadotropin-releasing hormone agonist on ovarian cancer cell growth

1 reference

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21 January 2018

Protease-resistant form of insulin-like growth factor-binding protein 5 is an inhibitor of insulin-like growth factor-I actions on porcine smooth muscle cells in culture.

1 reference

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Insulin-like growth factor (IGF) I and retinoic acid induce the synthesis of IGF-binding protein 5 in rat osteoblastic cells

1 reference

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21 January 2018

Proteolytic cleavage of insulin-like growth factor binding protein 4 (IGFBP-4). Localization of cleavage site to non-homologous region of native IGFBP-4.

1 reference

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21 January 2018

Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit

1 reference

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21 January 2018

Expression of Variant Forms of Insulin Receptor Substrate-1 Identified in Patients with Noninsulin-Dependent Diabetes Mellitus1

1 reference

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21 January 2018

Structure-function analysis of the human insulin-like growth factor binding protein-4.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000070200

21 January 2018

Isolation and characterization of circulating 13-kDa C-terminal fragments of human insulin-like growth factor binding protein-5

1 reference

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21 January 2018

Amino acids within the extracellular matrix (ECM) binding region (201-218) of rat insulin-like growth factor binding protein (IGFBP)-5 are important determinants in binding IGF-I.

1 reference

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21 January 2018

Membrane-associated insulin-like growth factor-binding protein-3 inhibits insulin-like growth factor-I-induced insulin-like growth factor-I receptor signaling in ishikawa endometrial cancer cells

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21 January 2018

The human insulin-like growth factor (IGF) binding protein-3 inhibits the growth of fibroblasts with a targeted disruption of the IGF-I receptor gene

1 reference

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21 January 2018

The Insulin-like Growth Factor (IGF) Binding Site of Bovine Insulin-like Growth Factor Binding Protein-2 (bIGFBP-2) Probed by Iodination

1 reference

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21 January 2018

Localization of an Insulin-like Growth Factor (IGF) Binding Site of Bovine IGF Binding Protein-2 Using Disulfide Mapping and Deletion Mutation Analysis of the C-terminal Domain

1 reference

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21 January 2018

Substitution of specific amino acids in insulin-like growth factor (IGF) binding protein 5 alters heparin binding and its change in affinity for IGF-I response to heparin

1 reference

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21 January 2018

Solution structure of human insulin-like growth factor II; recognition sites for receptors and binding proteins.

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7 January 2021

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10.1074/JBC.M000070200

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