Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53 (Q22009955)

GOA release 2020-03-11

tumor protein p53

1 reference

GOA release 2020-03-11

Y Zhang

1

Y

Zhang

1 reference

PubMed

PubMed publication ID

10360174

7 February 2023

Y Xiong

series ordinal

2

author given names

Y

author last names

Xiong

1 reference

PubMed

PubMed publication ID

10360174

The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein

7 February 2023

language of work or name

English

0 references

publication date

May 1999

0 references

published in

Molecular Cell

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volume

3

0 references

issue

5

0 references

page(s)

579-91

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cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980351-2

7 January 2021

p14ARF links the tumour suppressors RB and p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980351-2

7 January 2021

E1A signaling to p53 involves the p19(ARF) tumor suppressor

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980351-2

7 January 2021

A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980351-2

7 January 2021

The CDKN2A (p16) gene and human cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980351-2

7 January 2021

Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980351-2

7 January 2021

p300/MDM2 complexes participate in MDM2-mediated p53 degradation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980351-2

7 January 2021

Mdm2 promotes the rapid degradation of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980351-2

7 January 2021

RB regulates the stability and the apoptotic function of p53 via MDM2

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980351-2

7 January 2021

A cell cycle regulator potentially involved in genesis of many tumor types

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980351-2

7 January 2021

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980351-2

7 January 2021

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980351-2

7 January 2021

Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980351-2

7 January 2021

Regulation of p53 stability by Mdm2

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980351-2

7 January 2021

Localization of nascent RNA and CREB binding protein with the PML-containing nuclear body.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980351-2

7 January 2021

p53, the cellular gatekeeper for growth and division

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980351-2

7 January 2021

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980351-2

7 January 2021

p19ARF links the tumour suppressor p53 to Ras

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980351-2

7 January 2021

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980351-2

7 January 2021

Signaling to p53: breaking the MDM2-p53 circuit

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980351-2

7 January 2021

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980351-2

7 January 2021

Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980351-2

7 January 2021

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980351-2

7 January 2021

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980351-2

7 January 2021

Tumor surveillance via the ARF-p53 pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980351-2

7 January 2021

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980351-2

7 January 2021

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980351-2

7 January 2021

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980351-2

7 January 2021

Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980351-2

7 January 2021

Interaction between the retinoblastoma protein and the oncoprotein MDM2

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980351-2

7 January 2021

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980351-2

7 January 2021

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980351-2

7 January 2021