Tumor necrosis factor (ligand) superfamily, member 4 (Q21992452)

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mammalian protein found in Mus musculus

tax-transcriptionally activated glycoprotein 1 ligand
tumor necrosis factor ligand superfamily member 4
atherosclerosis 1
Tnfsf4
OX40L
OX40 ligand
tumor necrosis factor ligand 2b

Language	Label	Description	Also known as
English	Tumor necrosis factor (ligand) superfamily, member 4	mammalian protein found in Mus musculus	tax-transcriptionally activated glycoprotein 1 ligand tumor necrosis factor ligand superfamily member 4 atherosclerosis 1 Tnfsf4 OX40L OX40 ligand tumor necrosis factor ligand 2b

Statements

1 reference

25 May 2022

UniProt protein ID

Tumour necrosis factor-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P43488

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Tumour necrosis factor domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tumour necrosis factor, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

cytokine activity

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

protein binding

determination method or standard

1 reference

9 May 2019

The crystal structure of the costimulatory OX40-OX40L complex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

tumor necrosis factor receptor superfamily binding

determination method or standard

3 references

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43488&geneProductId=UniProtKB:P43488

determination method or standard

24 April 2018

Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43488&geneProductId=UniProtKB:P43488

determination method or standard

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43488&geneProductId=UniProtKB:P43488

determination method or standard

tumor necrosis factor receptor superfamily binding

determination method or standard

4 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

9 May 2019

Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

integral component of membrane

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

determination method or standard

extracellular space

determination method or standard

4 references

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

biological process

response to nitrogen dioxide

determination method or standard

1 reference

9 May 2019

NO2 inhalation induces maturation of pulmonary CD11c+ cells that promote antigenspecific CD4+ T cell polarization

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

T-helper 2 cell activation

determination method or standard

1 reference

9 May 2019

The role of OX40 ligand interactions in the development of the Th2 response to the gastrointestinal nematode parasite Heligmosomoides polygyrus

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

negative regulation of interferon-gamma production

determination method or standard

1 reference

9 May 2019

CD4 T cell cytokine differentiation: the B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

positive regulation of CD4-positive, alpha-beta T cell differentiation

determination method or standard

1 reference

9 May 2019

Comparison of OX40 ligand and CD70 in the promotion of CD4+ T cell responses

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

positive regulation of interleukin-4-dependent isotype switching to IgE isotypes

determination method or standard

1 reference

9 May 2019

The role of OX40 ligand interactions in the development of the Th2 response to the gastrointestinal nematode parasite Heligmosomoides polygyrus

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

negative regulation of regulatory T cell differentiation

determination method or standard

1 reference

9 May 2019

OX40/OX40L costimulation affects induction of Foxp3+ regulatory T cells in part by expanding memory T cells in vivo

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

positive regulation of immunoglobulin mediated immune response

determination method or standard

1 reference

9 May 2019

The role of OX40 ligand interactions in the development of the Th2 response to the gastrointestinal nematode parasite Heligmosomoides polygyrus

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

positive regulation of interleukin-12 production

determination method or standard

1 reference

9 May 2019

OX40 ligand regulates inflammation and mortality in the innate immune response to sepsis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

positive regulation of interleukin-10 production

determination method or standard

1 reference

9 May 2019

OX40 ligand regulates inflammation and mortality in the innate immune response to sepsis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

positive regulation of immune effector process

determination method or standard

1 reference

9 May 2019

OX40/OX40L costimulation affects induction of Foxp3+ regulatory T cells in part by expanding memory T cells in vivo

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

regulation of adaptive immune response

determination method or standard

1 reference

9 May 2019

OX40 ligand regulates inflammation and mortality in the innate immune response to sepsis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

response to virus

determination method or standard

1 reference

9 May 2019

Comparison of OX40 ligand and CD70 in the promotion of CD4+ T cell responses

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

negative regulation of activation-induced cell death of T cells

determination method or standard

1 reference

9 May 2019

OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

positive regulation of memory T cell activation

determination method or standard

1 reference

9 May 2019

The role of OX40 ligand interactions in the development of the Th2 response to the gastrointestinal nematode parasite Heligmosomoides polygyrus

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

negative regulation of extrinsic apoptotic signaling pathway

determination method or standard

1 reference

9 May 2019

OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

cholesterol metabolic process

determination method or standard

1 reference

9 May 2019

Ath-1, a gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

positive regulation of T-helper 2 cell activation

determination method or standard

1 reference

9 May 2019

The role of OX40 ligand interactions in the development of the Th2 response to the gastrointestinal nematode parasite Heligmosomoides polygyrus

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

negative regulation of DNA-binding transcription factor activity

determination method or standard

1 reference

9 May 2019

Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

cellular response to nitrogen dioxide

determination method or standard

1 reference

9 May 2019

NO2 inhalation induces maturation of pulmonary CD11c+ cells that promote antigenspecific CD4+ T cell polarization

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

negative regulation of T cell apoptotic process

determination method or standard

1 reference

9 May 2019

OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

positive regulation of interleukin-13 production

determination method or standard

1 reference

9 May 2019

Gastrointestinal dendritic cells promote Th2 skewing via OX40L

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

negative regulation of T-helper 1 cell differentiation

determination method or standard

1 reference

9 May 2019

CD4 T cell cytokine differentiation: the B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

blood vessel development

determination method or standard

1 reference

9 May 2019

OX40 ligand plays an important role in the development of atherosclerosis through vasa vasorum neovascularization

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

acute inflammatory response

determination method or standard

1 reference

9 May 2019

OX40 ligand regulates inflammation and mortality in the innate immune response to sepsis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

CD4-positive, alpha-beta T cell costimulation

determination method or standard

1 reference

9 May 2019

Comparison of OX40 ligand and CD70 in the promotion of CD4+ T cell responses

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

positive regulation of T cell cytokine production

determination method or standard

immune response

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

positive regulation of alpha-beta T cell proliferation

determination method or standard

1 reference

9 May 2019

OX40-OX40 ligand interaction through T cell-T cell contact contributes to CD4 T cell longevity

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

positive regulation of T-helper 2 cell differentiation

determination method or standard

1 reference

9 May 2019

Gastrointestinal dendritic cells promote Th2 skewing via OX40L

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

positive regulation of memory T cell differentiation

determination method or standard

1 reference

9 May 2019

OX40/OX40L costimulation affects induction of Foxp3+ regulatory T cells in part by expanding memory T cells in vivo

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

regulation of inflammatory response

determination method or standard

1 reference

9 May 2019

Costimulatory molecule OX40L is critical for both Th1 and Th2 responses in allergic inflammation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

chemokine (C-C motif) ligand 11 production

determination method or standard

1 reference

9 May 2019

Costimulatory molecule OX40L is critical for both Th1 and Th2 responses in allergic inflammation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

positive regulation of CD4-positive, alpha-beta T cell costimulation

determination method or standard

1 reference

9 May 2019

Comparison of OX40 ligand and CD70 in the promotion of CD4+ T cell responses

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

positive regulation of B cell activation

determination method or standard

1 reference

9 May 2019

CD4 T cell cytokine differentiation: the B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

memory T cell activation

determination method or standard

1 reference

9 May 2019

The role of OX40 ligand interactions in the development of the Th2 response to the gastrointestinal nematode parasite Heligmosomoides polygyrus

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

positive regulation of T cell costimulation

determination method or standard

1 reference

9 May 2019

Comparison of OX40 ligand and CD70 in the promotion of CD4+ T cell responses

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

innate immune response

determination method or standard

1 reference

9 May 2019

OX40 ligand regulates inflammation and mortality in the innate immune response to sepsis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

positive regulation of type 2 immune response

determination method or standard

3 references

9 May 2019

The role of OX40 ligand interactions in the development of the Th2 response to the gastrointestinal nematode parasite Heligmosomoides polygyrus

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

9 May 2019

Dendritic cell expression of OX40 ligand acts as a costimulatory, not polarizing, signal for optimal Th2 priming and memory induction in vivo

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

9 May 2019

Gastrointestinal dendritic cells promote Th2 skewing via OX40L

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

inflammatory response

determination method or standard

1 reference

24 April 2018

OX40/OX40L interaction induces the expression of CXCR5 and contributes to chronic colitis induced by dextran sulfate sodium in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43488&geneProductId=UniProtKB:P43488

determination method or standard

negative regulation of transcription, DNA-templated

determination method or standard

1 reference

9 May 2019

Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

positive regulation of T cell migration

determination method or standard

1 reference

9 May 2019

CD4 T cell cytokine differentiation: the B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

defense response to nematode

determination method or standard

1 reference

9 May 2019

The role of OX40 ligand interactions in the development of the Th2 response to the gastrointestinal nematode parasite Heligmosomoides polygyrus

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

regulation of signaling receptor activity

determination method or standard

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

positive regulation of interleukin-4 production

determination method or standard

4 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

9 May 2019

The role of OX40 ligand interactions in the development of the Th2 response to the gastrointestinal nematode parasite Heligmosomoides polygyrus

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

9 May 2019

Gastrointestinal dendritic cells promote Th2 skewing via OX40L

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

9 May 2019

CD4 T cell cytokine differentiation: the B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

cellular response to lipopolysaccharide

determination method or standard

3 references

9 May 2019

Modulation of TNFSF expression in lymphoid tissue inducer cells by dendritic cells activated with Toll-like receptor ligands

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

inflammatory response

determination method or standard

signal transduction

determination method or standard

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43488

determination method or standard

Tumour necrosis factor, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P43488

Tumour necrosis factor domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P43488

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000028024

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000028024

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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