Suppressor of cytokine signaling 1 (Q21991681)

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mammalian protein found in Mus musculus

cytokine inducible SH2-containing protein 1
JAK-binding protein
Socs1
JAB
cytokine inducible SH2-containing protein 7
SSI-1
JAK2-binding protein
suppressor of cytokine signaling 1
STAT-induced STAT inhibitor 1

Language	Label	Description	Also known as
English	Suppressor of cytokine signaling 1	mammalian protein found in Mus musculus	cytokine inducible SH2-containing protein 1 JAK-binding protein Socs1 JAB cytokine inducible SH2-containing protein 7 SSI-1 JAK2-binding protein suppressor of cytokine signaling 1 STAT-induced STAT inhibitor 1

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

suppressor of cytokine signalling 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35716

SOCS box-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35716

SH2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35716

SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SOCS box domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SOCS1, SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

kinase inhibitor activity

determination method or standard

protein kinase inhibitor activity

determination method or standard

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35716&geneProductId=UniProtKB:O35716

determination method or standard

protein binding

determination method or standard

4 references

14 February 2019

TRIM8/GERP RING finger protein interacts with SOCS-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

14 February 2019

Pim serine/threonine kinases regulate the stability of Socs-1 protein

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

14 February 2019

A new protein containing an SH2 domain that inhibits JAK kinases

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

14 February 2019

Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

insulin-like growth factor receptor binding

determination method or standard

1 reference

27 March 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35716&geneProductId=UniProtKB:O35716

determination method or standard

protein kinase binding

determination method or standard

1 reference

27 March 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35716&geneProductId=UniProtKB:O35716

determination method or standard

1-phosphatidylinositol-3-kinase regulator activity

determination method or standard

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

cytoplasmic vesicle

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

determination method or standard

1 reference

27 March 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35716&geneProductId=UniProtKB:O35716

determination method or standard

cytoplasmic ribonucleoprotein granule

determination method or standard

1 reference

27 March 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35716&geneProductId=UniProtKB:O35716

determination method or standard

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

phosphatidylinositol 3-kinase complex

determination method or standard

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

biological process

regulation of protein phosphorylation

determination method or standard

1 reference

14 February 2019

Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

regulation of receptor signaling pathway via JAK-STAT

determination method or standard

1 reference

14 February 2019

Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor–induced STAT1 activation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

receptor signaling pathway via JAK-STAT

determination method or standard

1 reference

14 February 2019

Pim serine/threonine kinases regulate the stability of Socs-1 protein

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

intracellular signal transduction

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

negative regulation of protein kinase activity

determination method or standard

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35716&geneProductId=UniProtKB:O35716

determination method or standard

cytokine-mediated signaling pathway

determination method or standard

3 references

14 February 2019

The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

14 February 2019

Structure and function of a new STAT-induced STAT inhibitor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

14 February 2019

A new protein containing an SH2 domain that inhibits JAK kinases

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

cellular response to organic cyclic compound

determination method or standard

1 reference

14 February 2019

JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

cellular response to cytokine stimulus

determination method or standard

1 reference

14 February 2019

JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

negative regulation of insulin receptor signaling pathway

determination method or standard

1 reference

27 March 2018

Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35716&geneProductId=UniProtKB:O35716

determination method or standard

regulation of interferon-gamma-mediated signaling pathway

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

protein ubiquitination

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

cellular response to amino acid stimulus

determination method or standard

1 reference

14 February 2019

Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

regulation of growth

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

negative regulation of signal transduction

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

fat cell differentiation

determination method or standard

1 reference

14 February 2019

Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

negative regulation of receptor signaling pathway via JAK-STAT

determination method or standard

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

14 February 2019

SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

regulation of activation of Janus kinase activity

determination method or standard

1 reference

14 February 2019

Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor–induced STAT1 activation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

regulation of tyrosine phosphorylation of STAT protein

determination method or standard

1 reference

14 February 2019

Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor–induced STAT1 activation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

positive regulation of CD4-positive, alpha-beta T cell differentiation

determination method or standard

1 reference

14 February 2019

The transcription factor ThPOK suppresses Runx3 and imposes CD4(+) lineage fate by inducing the SOCS suppressors of cytokine signaling.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

negative regulation of CD8-positive, alpha-beta T cell differentiation

determination method or standard

1 reference

14 February 2019

The transcription factor ThPOK suppresses Runx3 and imposes CD4(+) lineage fate by inducing the SOCS suppressors of cytokine signaling.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

positive regulation of regulatory T cell differentiation

determination method or standard

1 reference

27 March 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35716&geneProductId=UniProtKB:O35716

determination method or standard

negative regulation of kinase activity

determination method or standard

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

negative regulation of tyrosine phosphorylation of STAT protein

determination method or standard

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

14 February 2019

Structure and function of a new STAT-induced STAT inhibitor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

regulation of phosphatidylinositol 3-kinase activity

determination method or standard

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

negative regulation of insulin receptor signaling pathway

determination method or standard

2 references

phosphatidylinositol phosphate biosynthetic process

determination method or standard

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716

determination method or standard

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35716

SOCS box domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35716

SOCS1, SH2 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35716

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000038121

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000038121

ENSMUSP00000155530

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000155530

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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