Myosin, heavy polypeptide 6, cardiac muscle, alpha (Q21986568)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q02566

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q02566

kinesin motor domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q02566

Myosin, N-terminal, SH3-like, protein family

1 reference

Myosin head, motor domain, protein family

1 reference

Myosin tail, protein family

1 reference

IQ motif, EF-hand binding site, protein family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

1 reference

14 February 2019

calmodulin binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

1 reference

14 February 2019

protein binding

3 references

14 February 2019

Cardiac myosin binding protein C phosphorylation is cardioprotective

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

Cardiac myosin binding protein C phosphorylation is cardioprotective

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

Determination of the critical residues responsible for cardiac myosin binding protein C's interactions

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

actin binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

1 reference

14 February 2019

cytoskeletal motor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

1 reference

14 February 2019

actin filament binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

1 reference

14 February 2019

microfilament motor activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

Differential cross-bridge kinetics of FHC myosin mutations R403Q and R453C in heterozygous mouse myocardium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

microtubule motor activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02566&geneProductId=UniProtKB:Q02566

1 reference

24 April 2018

microtubule binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02566&geneProductId=UniProtKB:Q02566

1 reference

24 April 2018

ATP binding

calcium-dependent ATPase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

identical protein binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

protein homodimerization activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

protein heterodimerization activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

cell component

stress fiber

1 reference

14 February 2019

Myosin regulatory light chains are required to maintain the stability of myosin II and cellular integrity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

Z discdkac

1 reference

14 February 2019

Myosin regulatory light chains are required to maintain the stability of myosin II and cellular integrity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

myosin filament

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

1 reference

14 February 2019

myosin complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

14 February 2019

Changes in expression of nonmuscle myosin heavy chain isoforms during muscle and nonmuscle tissue development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

Differential cross-bridge kinetics of FHC myosin mutations R403Q and R453C in heterozygous mouse myocardium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

Neonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the alpha cardiac myosin heavy chain gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

mitochondrion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

muscle myosin complex

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

myofibril

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

14 February 2019

Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

Neonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the alpha cardiac myosin heavy chain gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

regulation of heart contraction

biological process

7 references

14 February 2019

Altered crossbridge kinetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

Electrophysiological abnormalities and arrhythmias in alpha MHC mutant familial hypertrophic cardiomyopathy mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

Altered cardiac excitation-contraction coupling in mutant mice with familial hypertrophic cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

A mouse model of familial hypertrophic cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

QT dispersion in alpha-myosin heavy-chain familial hypertrophic cardiomyopathy mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

Neonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the alpha cardiac myosin heavy chain gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

cardiac muscle contraction

1 reference

14 February 2019

Neonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the alpha cardiac myosin heavy chain gene

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

in utero embryonic development

1 reference

14 February 2019

Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

actin filament-based movement

1 reference

14 February 2019

Differential cross-bridge kinetics of FHC myosin mutations R403Q and R453C in heterozygous mouse myocardium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

BMP signaling pathway

1 reference

14 February 2019

Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

regulation of blood pressure

1 reference

14 February 2019

Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

myofibril assembly

3 references

14 February 2019

Altered crossbridge kinetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

Neonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the alpha cardiac myosin heavy chain gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

cardiac muscle hypertrophy in response to stress

1 reference

14 February 2019

The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

canonical Wnt signaling pathway

1 reference

14 February 2019

Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

regulation of ATP-dependent activity

1 reference

14 February 2019

Differential cross-bridge kinetics of FHC myosin mutations R403Q and R453C in heterozygous mouse myocardium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

sarcomere organization

1 reference

14 February 2019

Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

visceral muscle development

1 reference

14 February 2019

A polymorphic modifier gene alters the hypertrophic response in a murine model of familial hypertrophic cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

regulation of heart growth

1 reference

14 February 2019

Control of stress-dependent cardiac growth and gene expression by a microRNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

regulation of the force of heart contraction

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

regulation of heart rate

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

striated muscle contraction

11 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

Altered crossbridge kinetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

Electrophysiological abnormalities and arrhythmias in alpha MHC mutant familial hypertrophic cardiomyopathy mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

Altered cardiac excitation-contraction coupling in mutant mice with familial hypertrophic cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

A mouse model of familial hypertrophic cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

Neonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the alpha cardiac myosin heavy chain gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

Differential cross-bridge kinetics of FHC myosin mutations R403Q and R453C in heterozygous mouse myocardium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

adult heart development

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

Altered crossbridge kinetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

Neonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the alpha cardiac myosin heavy chain gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

Differential cross-bridge kinetics of FHC myosin mutations R403Q and R453C in heterozygous mouse myocardium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02566

microtubule-based movement

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02566&geneProductId=UniProtKB:Q02566

1 reference

24 April 2018