Myocyte enhancer factor 2C (Q21985118)

MADS MEF2-like, protein family

1 reference

based on heuristic

inferred from protein domain or family

Holliday junction regulator protein family C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Transcription factor, MADS-box, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

protein dimerization activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

1 reference

14 February 2019

DNA-binding transcription factor activity

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

DNA-binding transcription activator activity, RNA polymerase II-specific

13 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

5 June 2018

Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

5 June 2018

Regulatory role of MEF2D in serum induction of the c-jun promoter

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

5 June 2018

Regulation of skeletal muscle sarcomere integrity and postnatal muscle function by Mef2c

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

5 June 2018

Myocyte enhancer factor (MEF) 2C: a tissue-restricted member of the MEF-2 family of transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

MEF2B is a potent transactivator expressed in early myogenic lineages

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

Regulatory role of MEF2D in serum induction of the c-jun promoter

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

Regulation of skeletal muscle sarcomere integrity and postnatal muscle function by Mef2c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

Myocyte enhancer factor (MEF) 2C: a tissue-restricted member of the MEF-2 family of transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

histone deacetylase binding

1 reference

5 June 2018

Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

RNA polymerase II general transcription initiation factor activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

6 references

11 October 2018

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

7 November 2018

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

core promoter sequence-specific DNA binding

1 reference

24 April 2018

Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

RNA polymerase II transcription regulatory region sequence-specific DNA binding

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

BOP, a regulator of right ventricular heart development, is a direct transcriptional target of MEF2C in the developing heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

HMG box domain binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

3 references

5 June 2018

Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

5 June 2018

Regulatory role of MEF2D in serum induction of the c-jun promoter

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

14 February 2019

MEF2B is a potent transactivator expressed in early myogenic lineages

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

DNA-binding transcription activator activity, RNA polymerase II-specific

1 reference

5 June 2018

MEF2B is a potent transactivator expressed in early myogenic lineages

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

chromatin binding

1 reference

14 February 2019

Differentiation-dependent lysine 4 acetylation enhances MEF2C binding to DNA in skeletal muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

cis-regulatory region sequence-specific DNA binding

1 reference

14 February 2019

TRIM72, a novel negative feedback regulator of myogenesis, is transcriptionally activated by the synergism of MyoD (or myogenin) and MEF2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

protein binding

6 references

14 February 2019

Sumoylation regulates nuclear localization of lipin-1alpha in neuronal cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

A p38 MAPK-MEF2C pathway regulates B-cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

Coactivation of MEF2 by the SAP domain proteins myocardin and MASTR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

MEF2C regulates c‐Jun but not TNF‐α gene expression in stimulated mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-β-TAK1-dependent mechanism

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

sequence-specific DNA binding

3 references

14 February 2019

The MADS box transcription factor MEF2C regulates melanocyte development and is a direct transcriptional target and partner of SOX10

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

Skeletal myosin light chain kinase regulates skeletal myogenesis by phosphorylation of MEF2C

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

MEF2C transcription factor controls chondrocyte hypertrophy and bone development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

DNA binding

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

14 February 2019

Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

The cardiac pacemaker-specific channel Hcn4 is a direct transcriptional target of MEF2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

VITO-1 is an essential cofactor of TEF1-dependent muscle-specific gene regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

DNA-binding transcription factor activity, RNA polymerase II-specific

4 references

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

7 November 2018

The MADS box transcription factor MEF2C regulates melanocyte development and is a direct transcriptional target and partner of SOX10

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

7 November 2018

The transcription factor MEF2C is required for craniofacial development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

7 November 2018

An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

RNA polymerase II cis-regulatory region sequence-specific DNA binding

Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

Regulatory role of MEF2D in serum induction of the c-jun promoter

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

DNA-binding transcription activator activity, RNA polymerase II-specific

15 references

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

11 October 2018

Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

11 October 2018

Regulatory role of MEF2D in serum induction of the c-jun promoter

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

11 October 2018

Myocyte enhancer factor (MEF) 2C: a tissue-restricted member of the MEF-2 family of transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

11 October 2018

Regulation of skeletal muscle sarcomere integrity and postnatal muscle function by Mef2c

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

11 October 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

1 January 2018

Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

1 January 2018

Regulatory role of MEF2D in serum induction of the c-jun promoter

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

1 January 2018

MEF2B is a potent transactivator expressed in early myogenic lineages

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

1 January 2018

Regulation of skeletal muscle sarcomere integrity and postnatal muscle function by Mef2c

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

1 January 2018

Myocyte enhancer factor (MEF) 2C: a tissue-restricted member of the MEF-2 family of transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

DNA-binding transcription activator activity, RNA polymerase II-specific

histone deacetylase binding

DNA-binding transcription factor activity, RNA polymerase II-specific

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

6 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

The MADS box transcription factor MEF2C regulates melanocyte development and is a direct transcriptional target and partner of SOX10

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

The transcription factor MEF2C is required for craniofacial development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

RNA polymerase II general transcription initiation factor activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

cell component

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

nucleus

11 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

SOX18 directly interacts with MEF2C in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

The MADS box transcription factor MEF2C regulates melanocyte development and is a direct transcriptional target and partner of SOX10

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca(2+)-dependent signaling cascade

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

Differentiation-dependent lysine 4 acetylation enhances MEF2C binding to DNA in skeletal muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

IC

nuclear speck

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

sarcoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

1 reference

14 February 2019

protein-containing complex

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

nucleoplasm

negative regulation of neuron apoptotic process

1 reference

14 February 2019

Myocyte enhancer factor 2C as a neurogenic and antiapoptotic transcription factor in murine embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

embryonic skeletal system morphogenesis

1 reference

14 February 2019

The transcription factor MEF2C is required for craniofacial development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

myotube differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

positive regulation of skeletal muscle tissue development

cell morphogenesis involved in neuron differentiation

1 reference

14 February 2019

Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

regulation of synapse assembly

1 reference

14 February 2019

MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

outflow tract morphogenesis

1 reference

14 February 2019

Cooperative interaction of Nkx2.5 and Mef2c transcription factors during heart development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

monocyte differentiation

1 reference

14 February 2019

The MADS transcription factor Mef2c is a pivotal modulator of myeloid cell fate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

sinoatrial valve morphogenesis

1 reference

14 February 2019

MEF2C is required for the normal allocation of cells between the ventricular and sinoatrial precursors of the primary heart field

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

negative regulation of ossification

1 reference

14 February 2019

MEF2C is required for the normal allocation of cells between the ventricular and sinoatrial precursors of the primary heart field

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

blood vessel remodeling

positive regulation of cardiac muscle cell proliferation

1 reference

14 February 2019

MEF2C is required for the normal allocation of cells between the ventricular and sinoatrial precursors of the primary heart field

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

humoral immune response

1 reference

14 February 2019

A p38 MAPK-MEF2C pathway regulates B-cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

positive regulation of alkaline phosphatase activity

1 reference

14 February 2019

Myocyte enhancer factor 2c, an osteoblast transcription factor identified by dimethyl sulfoxide (DMSO)-enhanced mineralization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

negative regulation of epithelial cell proliferation

1 reference

14 February 2019

Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

regulation of synaptic transmission, glutamatergic

1 reference

14 February 2019

MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

melanocyte differentiation

1 reference

14 February 2019

The MADS box transcription factor MEF2C regulates melanocyte development and is a direct transcriptional target and partner of SOX10

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

apoptotic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

1 reference

14 February 2019

B cell receptor signaling pathway

1 reference

14 February 2019

A p38 MAPK-MEF2C pathway regulates B-cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

cellular response to calcium ion

1 reference

14 February 2019

Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca(2+)-dependent signaling cascade

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

cellular response to transforming growth factor beta stimulus

renal tubule morphogenesis

1 reference

14 February 2019

Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

nephron tubule epithelial cell differentiation

1 reference

14 February 2019

Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

cell fate commitment

1 reference

14 February 2019

Regulation of lymphoid versus myeloid fate 'choice' by the transcription factor Mef2c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

cardiac ventricle formation

regulation of transcription, DNA-templated

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

cardiac muscle cell differentiation

Skeletal myosin light chain kinase regulates skeletal myogenesis by phosphorylation of MEF2C

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

NAS

14 February 2019

Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

Cooperative interaction of Nkx2.5 and Mef2c transcription factors during heart development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

regulation of neuron apoptotic process

1 reference

14 February 2019

In vivo analysis of MEF2 transcription factors in synapse regulation and neuronal survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

neuron development

1 reference

14 February 2019

Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

platelet formation

1 reference

14 February 2019

Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

smooth muscle cell differentiation

1 reference

14 February 2019

Requirement of the MADS-box transcription factor MEF2C for vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

positive regulation of protein homodimerization activity

1 reference

14 February 2019

Cooperative interaction of Nkx2.5 and Mef2c transcription factors during heart development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

negative regulation of gene expression

1 reference

14 February 2019

MEF2C is required for the normal allocation of cells between the ventricular and sinoatrial precursors of the primary heart field

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

1 reference

5 June 2018

cellular response to trichostatin A

1 reference

14 February 2019

Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

positive regulation of transcription, DNA-templated

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

SOX18 directly interacts with MEF2C in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

The MADS box transcription factor MEF2C regulates melanocyte development and is a direct transcriptional target and partner of SOX10

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

MEF2C regulates c‐Jun but not TNF‐α gene expression in stimulated mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

Combinatorial cis-acting elements control tissue-specific activation of the cardiac troponin I gene in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

heart development

The transcription factor MEF2C-null mouse exhibits complex vascular malformations and reduced cardiac expression of angiopoietin 1 and VEGF

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

Requirement of the MADS-box transcription factor MEF2C for vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

epithelial cell proliferation involved in renal tubule morphogenesis

1 reference

14 February 2019

Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

cardiac muscle hypertrophy in response to stress

1 reference

14 February 2019

MEF2 is upregulated during cardiac hypertrophy and is required for normal post-natal growth of the myocardium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

positive regulation of B cell proliferation

1 reference

14 February 2019

A p38 MAPK-MEF2C pathway regulates B-cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

positive regulation of neuron differentiation

1 reference

14 February 2019

Myocyte enhancer factor 2C as a neurogenic and antiapoptotic transcription factor in murine embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

excitatory postsynaptic potential

2 references

learning or memory

positive regulation of macrophage apoptotic process

1 reference

14 February 2019

MEF2C mediates the activation induced cell death (AICD) of macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

positive regulation of cardiac muscle cell differentiation

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

MEF2C is required for the normal allocation of cells between the ventricular and sinoatrial precursors of the primary heart field

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

cellular response to parathyroid hormone stimulus

primary heart field specification

1 reference

14 February 2019

MEF2C is required for the normal allocation of cells between the ventricular and sinoatrial precursors of the primary heart field

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

secondary heart field specification

1 reference

14 February 2019

BOP, a regulator of right ventricular heart development, is a direct transcriptional target of MEF2C in the developing heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

regulation of dendritic spine development

1 reference

14 February 2019

MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

regulation of germinal center formation

1 reference

14 February 2019

Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

roof of mouth development

1 reference

14 February 2019

The transcription factor MEF2C is required for craniofacial development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

1 reference

14 February 2019

chondrocyte differentiation

1 reference

14 February 2019

MEF2C transcription factor controls chondrocyte hypertrophy and bone development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

positive regulation of bone mineralization

1 reference

14 February 2019

Myocyte enhancer factor 2c, an osteoblast transcription factor identified by dimethyl sulfoxide (DMSO)-enhanced mineralization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

neural crest cell differentiation

1 reference

14 February 2019

The MADS box transcription factor MEF2C regulates melanocyte development and is a direct transcriptional target and partner of SOX10

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

neuron migration

1 reference

14 February 2019

Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

B cell homeostasis

1 reference

14 February 2019

Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

negative regulation of transcription by RNA polymerase II

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

Repression of p53-dependent sequence-specific transactivation by MEF2c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

regulation of neurotransmitter secretion

1 reference

14 February 2019

MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

cellular response to fluid shear stress

1 reference

14 February 2019

Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

nervous system development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

1 reference

14 February 2019

regulation of synaptic plasticity

1 reference

14 February 2019

In vivo analysis of MEF2 transcription factors in synapse regulation and neuronal survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

regulation of NMDA receptor activity

1 reference

14 February 2019

MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

muscle cell fate determination

1 reference

14 February 2019

Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

positive regulation of osteoblast differentiation

1 reference

14 February 2019

Myocyte enhancer factor 2c, an osteoblast transcription factor identified by dimethyl sulfoxide (DMSO)-enhanced mineralization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

regulation of synaptic activity

3 references

14 February 2019

MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

In vivo analysis of MEF2 transcription factors in synapse regulation and neuronal survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

osteoblast differentiation

regulation of sarcomere organization

IEP

1 reference

14 February 2019

Regulation of skeletal muscle sarcomere integrity and postnatal muscle function by Mef2c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

skeletal muscle cell differentiation

NAS

positive regulation of behavioral fear response

1 reference

14 February 2019

Myocyte enhancer factor 2C as a neurogenic and antiapoptotic transcription factor in murine embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

glomerulus morphogenesis

1 reference

14 February 2019

Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

germinal center formation

1 reference

14 February 2019

A p38 MAPK-MEF2C pathway regulates B-cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

positive regulation of cell proliferation in bone marrow

1 reference

14 February 2019

Regulation of progenitor cell proliferation and granulocyte function by microRNA-223

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

MAPK cascade

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

A p38 MAPK-MEF2C pathway regulates B-cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

MEF2C regulates c‐Jun but not TNF‐α gene expression in stimulated mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

regulation of AMPA receptor activity

1 reference

14 February 2019

MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

1 reference

14 February 2019

B cell proliferation

1 reference

14 February 2019

Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

positive regulation of gene expression

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

Myocyte enhancer factor 2c, an osteoblast transcription factor identified by dimethyl sulfoxide (DMSO)-enhanced mineralization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

MEF2C is required for the normal allocation of cells between the ventricular and sinoatrial precursors of the primary heart field

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

Myocyte enhancer factor 2C as a neurogenic and antiapoptotic transcription factor in murine embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

positive regulation of myoblast differentiation

cartilage morphogenesis

1 reference

14 February 2019

The transcription factor MEF2C is required for craniofacial development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

embryonic viscerocranium morphogenesis

1 reference

14 February 2019

The transcription factor MEF2C is required for craniofacial development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

ventricular cardiac muscle cell differentiation

1 reference

14 February 2019

MEF2C is required for the normal allocation of cells between the ventricular and sinoatrial precursors of the primary heart field

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

cellular response to lipopolysaccharide

1 reference

14 February 2019

A p38 MAPK-MEF2C pathway regulates B-cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

skeletal muscle tissue development

1 reference

14 February 2019

Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

regulation of megakaryocyte differentiation

1 reference

14 February 2019

Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

positive regulation of transcription by RNA polymerase II

17 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

BOP, a regulator of right ventricular heart development, is a direct transcriptional target of MEF2C in the developing heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

PC4 coactivates MyoD by relieving the histone deacetylase 4-mediated inhibition of myocyte enhancer factor 2C.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

MEF2C transcription factor controls chondrocyte hypertrophy and bone development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

TRIM72, a novel negative feedback regulator of myogenesis, is transcriptionally activated by the synergism of MyoD (or myogenin) and MEF2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

The transcription factor MEF2C is required for craniofacial development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

MEF2B is a potent transactivator expressed in early myogenic lineages

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

Regulatory role of MEF2D in serum induction of the c-jun promoter

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

MEF2C transcription factor controls chondrocyte hypertrophy and bone development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

c-Ski activates MyoD in the nucleus of myoblastic cells through suppression of histone deacetylases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

Coactivation of MEF2 by the SAP domain proteins myocardin and MASTR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

14 February 2019

Differentiation-dependent lysine 4 acetylation enhances MEF2C binding to DNA in skeletal muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

transcription by RNA polymerase II

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFN5&geneProductId=UniProtKB:Q8CFN5

positive regulation of cardiac muscle hypertrophy

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

transdifferentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

cellular response to retinoic acid

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

cellular response to growth factor stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFN5

Holliday junction regulator protein family C-terminal

has part(s)

1 reference

Transcription factor, MADS-box

1 reference

MADS MEF2-like

1 reference