Anoctamin 1, calcium activated chloride channel (Q21984963)

http://www.ebi.ac.uk/interpro/protein/Q8BHY3

Calcium-dependent chloride channel

1 reference

Transporter Classification Database ID

1.A.17.1.25

hierarchical database ID heuristic

2 October 2019

based on heuristic

Anoctamin, dimerisation domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

calcium activated cation channel activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

protein dimerization activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

1 reference

14 February 2019

protein homodimerization activity

1 reference

14 February 2019

Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

intracellular calcium activated chloride channel activity

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

14 February 2019

TMEM16A confers receptor-activated calcium-dependent chloride conductance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

14 February 2019

ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

14 February 2019

The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

14 February 2019

Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

14 February 2019

Expression and function of epithelial anoctamins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

14 February 2019

Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

protein heterodimerization activity

1 reference

14 February 2019

Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

voltage-gated chloride channel activity

1 reference

14 February 2019

The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

chloride channel activity

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

14 February 2019

CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

14 February 2019

iodide transmembrane transporter activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

cell component

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

1 reference

14 February 2019

integral component of membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

1 reference

14 February 2019

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

1 reference

14 February 2019

plasma membrane

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

14 February 2019

14 February 2019

The transmembrane protein TMEM16A is required for normal development of the murine trachea

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

14 February 2019

ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

14 February 2019

Expression and function of epithelial anoctamins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

chloride channel complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

1 reference

14 February 2019

external side of plasma membrane

1 reference

14 February 2019

Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

biological process

cation transport

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

trachea development

1 reference

14 February 2019

The transmembrane protein TMEM16A is required for normal development of the murine trachea

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

ion transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

1 reference

14 February 2019

detection of temperature stimulus involved in sensory perception of pain

IGI

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

1 reference

14 February 2019

phospholipase C-activating G protein-coupled receptor signaling pathway

1 reference

14 February 2019

The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

iodide transport

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

chloride transport

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

14 February 2019

14 February 2019

TMEM16A confers receptor-activated calcium-dependent chloride conductance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

14 February 2019

Expression and function of epithelial anoctamins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

14 February 2019

Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

detection of mechanical stimulus involved in sensory perception of pain

1 reference

14 February 2019

The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

positive regulation of insulin secretion involved in cellular response to glucose stimulus

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

14 February 2019

CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

14 February 2019

chloride transmembrane transport

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

14 February 2019

CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

14 February 2019

14 February 2019

The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BHY3

Anoctamin, dimerisation domain

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8BHY3

Identifiers

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

Transporter Classification Database ID

1.A.17.1.25

2 references

Transporter Classification database

13 March 2020

Transporter Classification database